Mass spectrometric identification of an HLA-A*0201 epitope from Plasmodium falciparum MSP-1

International Immunology

Volumn 20, Issue 11, 2008, Pages 1451-1456

  Carralot, Jean Philippe ^a   Lemmel, Claudia ^a   Stevanovic, Stefan ^a   Pascolo, Steve ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Epitope; HLA transgenic mice; Mass spectrometry; MSP 1; Plasmodium falciparum

Indexed keywords

EPITOPE; HLA A ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MALARIA VACCINE; MEMBRANE PROTEIN; MEROZOITE SURFACE PROTEIN; PEPTIDE; PEPTIDE VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PURIFICATION; ANTIGEN SPECIFICITY; ARTICLE; CALIBRATION; CELL LINE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOLOGICAL MONITORING; IMMUNOMODULATION; MALARIA FALCIPARUM; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PREDICTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN TARGETING; TARGET CELL; VACCINE PRODUCTION;

ANIMALS; ANTIGENS, PROTOZOAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HELA CELLS; HLA-A2 ANTIGEN; HUMANS; MALARIA, FALCIPARUM; MASS SPECTROMETRY; MEROZOITE SURFACE PROTEIN 1; MICE; MICE, TRANSGENIC; PEPTIDES; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 54949127192     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn102     Document Type: Article

References (24)

1. Sachs, J. and Malaney, P. 2002. The economic and social burden of malaria. Nature 415:680.
2. Good, M. F. 2001. Towards a blood-stage vaccine for malaria: Are we following all the leads? Nat. Rev. Immunol. 1:117.
3. Ballou, W. R., Arevalo-Herrera, M., Carucci, D. et al. 2004. Update on the clinical development of candidate malaria vaccines. Am. J. Trop. Med. Hyg. 71:239.
4. John, C. C., O'Donnell, R. A., Sumba, P. O. et al. 2004. Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J. Immunol. 173:666.
5. O'Donnell, R. A., de Koning-Ward, T. F., Burt, R. A. et al. 2001. Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J. Exp. Med. 193:1403.
6. Coban, C., Philipp, M. T., Purcell, J. E. et al. 2004. Induction of Plasmodium falciparum transmission-blocking antibodies in nonhuman primates by a combination of DNA and protein immunizations. Infect. Immun. 72:253.
7. Egan, A. F., Blackman, M. J. and Kaslow, D. C. 2000. Vaccine efficacy of recombinant Plasmodium falciparum merozoite surface protein 1 in malaria-naive, -exposed, and/or -rechallenged Aotus vociferans monkeys. Infect. Immun. 68:1418.
8. Kumar, S., Collins, W., Egan, A. et al. 2000. Immunogenicity and efficacy in aotus monkeys of four recombinant Plasmodium falciparum vaccines in multiple adjuvant formulations based on the 19-kilodalton C terminus of merozoite surface protein 1. Infect. Immun. 68:2215.
9. Lee, E. A., Palmer, D. R., Flanagan, K. L. et al. 2002. Induction of T helper type 1 and 2 responses to 19-kilodalton merozoite surface protein 1 in vaccinated healthy volunteers and adults naturally exposed to malaria. Infect. Immun. 70:1417.
10. Pan, W., Huang, D., Zhang, Q. et al. 2004. Fusion of two malaria vaccine candidate antigens enhances product yield, immunogenicity, and antibody-mediated inhibition of parasite growth in vitro. J. Immunol. 172:6167.
11. Siddiqui, W. A., Tam, L. Q., Kramer, K. J. et al. 1987. Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria. Proc. Natl Acad. Sci. USA 84:3014.
12. Cowman, A. F., Baldi, D. L., Duraisingh, M. et al. 2002. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 357:25.
13. Kauth, C. W., Epp, C., Bujard, H. and Lutz, R. 2003. The merozoite surface protein 1 complex of human malaria parasite Plasmodium falciparum: Interactions and arrangements of subunits. J. Biol. Chem. 278:22257.
14. Guevara Patino, J. A., Holder, A. A., McBride, J. S. and Blackman, M. J. 1997. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J. Exp. Med. 186:1689.
15. Pascolo, S., Schirle, M., Guckel, B. et al. 2001. A MAGE-A1 HLA-A A*0201 epitope identified by mass spectrometry. Cancer Res. 61:4072.
16. Pascolo, S., Bervas, N., Ure, J. M., Smith, A. G., Lemonnier, F. A. and Perarnau, B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J. Exp. Med. 185:2043.
17. Burghaus, P. A., Gerold, P., Pan, W., Schwarz, R. T., Lingelbach, K. and Bujard, H. 1999. Analysis of recombinant merozoite surface protein-1 of Plasmodium falciparum expressed in mammalian cells. Mol. Biochem. Parasitol. 104:171.
18. Pan, W., Ravot, E., Tolle, R. et al. 1999. Vaccine candidate MSP-1 from Plasmodium falciparum: A redesigned 4917 bp polynucleotide enables synthesis and isolation of full-length protein from Escherichia coli and mammalian cells. Nucleic Acids Res. 27:1094.
19. Rammensee, H., Bachmann, J., Emmerich, N. P., Bachor, O. A. and Stevanovic, S. 1999. SYFPEITHI: Database for MHC ligands and peptide motifs. Immunogenetics 50:213.
20. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G. and Rammensee, H. G. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
21. Seeger, F. H., Schirle, M., Gatfield, J. et al. 1999. The HLA-A*6601 peptide motif: Prediction by pocket structure and verification by peptide analysis. Immunogenetics 49:571.
22. Yi, A. K. and Krieg, A. M. 1998. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel. J. Immunol. 160:1240.
23. Schirle, M., Keilholz, W., Weber, B. et al. 2000. Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach. Eur. J. Immunol. 30:2216.
24. Chen, W., Masterman, K. A., Basta, S. et al. 2004. Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon. Eur. J. Immunol. 34:194.