Brain Copper Elevation and Neurological Changes in North Ronaldsay Sheep: a Model for Neurodegenerative Disease?

Journal of Comparative Pathology

Volumn 139, Issue 4, 2008, Pages 252-255

  Haywood, S ^a   Paris, J ^a   Ryvar, R ^a   Botteron, C ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

brain; copper toxicity; neurodegenerative disease; North Ronaldsay sheep; Wilson's disease

Indexed keywords

COPPER; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN INJURY; BRAIN LEVEL; BRAIN TISSUE; CHRONIC HEPATITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEGENERATIVE DISEASE; DISEASE MODEL; HOMEOSTASIS; IMMUNOREACTIVITY; LIVER PARENCHYMA; LIVER TOXICITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SHEEP; TRANSPORT KINETICS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; COPPER; DISEASE MODELS, ANIMAL; LIVER; NEURODEGENERATIVE DISEASES; SHEEP; SHEEP DISEASES;

ANIMALIA; OVIS ARIES;

EID: 54949100337     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2008.06.008     Document Type: Article

References (15)

1. Coyle J.T., and Puttfarken P. Oxidative stress, glutamate and neurodegenerative disorders. Science 262 (1993) 689-694
2. Dincer, Z. (1994). Copper toxicity in sheep: studies on copper chelation by ammonium tetra thiomolybdate (TTM) and metallothionein. PhD thesis, University of Liverpool.
3. Haywood S., Müller T., Mackenzie A.M., Müller W., Tanner M.S., Heinz-Erian P., Williams C.L., and Loughran M.J. Copper-induced hepatotoxicosis with hepatic stellate cell activation in North Ronaldsay lambs: a model for non-Wilsonian hepatic copper toxicosis of infants. Journal of Comparative Pathology 130 (2004) 266-277
4. Haywood S., Müller T., Müller W., Heinz-Erian P., Tanner M.S., and Ross G. Copper-associated liver disease in North Ronaldsay sheep: a possible animal model for non-Wilsonian hepatic copper toxicosis of infancy and childhood. Journal of Pathology 195 (2001) 264-269
5. Haywood S., Simpson D.M., Ross G., and Beynon R.J. The greater susceptibility of North Ronaldsay sheep compared with Cambridge sheep to copper-induced oxidative stress, mitochondrial damage and hepatic stellate cell activation. Journal of Comparative Pathology 133 (2005) 114-127
6. Herrtage M.E., Seymour C.A., Jefferies A.R., Blakemore W.F., and Palmer A.C. Inherited copper toxicosis in the Bedlington terrier: a report of two clinical cases. Journal of Small Animal Practice 28 (1987) 1127-1140
7. Hidalgo J., Penkowa M., Espejo C., Martinez-Caceres E.M., Carrasco J., Quitana A., Molinero A., Florit S., Giralt M., and Ortega-Aznar A. Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation. Experimental Biology and Medicine 231 (2006) 1450-1458
8. Howell J.Mc.C., Blakemore W.F., Hall G.A., Gopinath C., and Parker J.H. Chronic copper poisoning and changes in the central nervous system of sheep. Acta Neuropathologica (Berlin) 29 (1974) 9-24
9. Lindquist R.R. Studies on the pathogenesis of hepatolenticular degeneration. II. Cytochemical methods for the localization of copper. Archives of Pathology 87 (1969) 370-379
10. Maclachan G.K., and Johnston W.S. Copper poisoning in sheep from North Ronaldsay maintained on a diet of terrestrial herbage. Veterinary Record 111 (1982) 299-301
11. Mikol J., Vital C., Wassef M., Chappuis P., Poupon J., Lecharpentier M., and Woimant F. Extensive cortico-subcortical lesions in Wilson's disease: clinico-pathological study of two cases. Acta Neuropathologica (Berlin) 110 (2005) 451-458
12. Morgan K.T. Chronic copper toxicity of sheep: an ultrastructural study of spongiform leukoencephalopathy. Research in Veterinary Science 5 (1973) 88-95
13. Sayre L.M., Perry G., Atwood C., and Smith M.A. The role of metals in neurodegenerative diseases. Cellular and Molecular Biology 46 (2000) 731-741
14. Su L.-C., Ravanshad S., Owen C.A., McCall J.T., Zollman P.E., and Hardy R.M. A comparison of copper-loading disease in Bedlington terriers and Wilson's disease in humans. American Journal of Physiology 243 (1982) G231-G236
15. Wiener G., Field A.C., and Smith C. Deaths from copper toxicity of sheep at pasture and the use of fresh seaweed. Veterinary Record 101 (1977) 424-425