Screening for MRSA: A flawed hospital infection control intervention

Infection Control and Hospital Epidemiology

Volumn 29, Issue 11, 2008, Pages 1012-1018

  Wenzel, Richard P ^a,b   Bearman, Gonzalo ^a   Edmond, Michael B ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIUM ISOLATION; HEALTH CARE COST; HEALTH PROGRAM; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; INFECTION CONTROL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORBIDITY; MORTALITY; SCREENING TEST; VIRULENCE;

CROSS INFECTION; HOSPITALS; HUMANS; INFECTION CONTROL; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL INFECTIONS; UNITED STATES; VANCOMYCIN RESISTANCE;

EID: 54949097435     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/593120     Document Type: Article

References (64)

1. Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest 2003; 111:1265-1273.
2. Klevens RM, Morrison MA, Nadle J, et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007; 298: 1763-1771.
3. Wenzel RP, Bearman G, Edmond MB. Community-acquired methicillin-resistant Staphylococcus aureus (MRSA): new issues for infection control. Int J Antimicrob Agents 2007; 30:210-212.
4. Huang SS, Yokoe DS, Hinrichsen VL, et al. Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis 2006; 43:971-978.
5. Robicsek A, Beaumont M S, Paule SM, et al. Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Ann Intern Med 2008; 148:409-418.
6. Wertheim HF, Vos MC, Boelens HA, et al. Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use. J Hosp Infect 2004; 56:321-325.
7. Herr CE, Heckrodt TH, Hofmann FA, Schnettler R, Eikmann TF. Additional costs for preventing the spread of methicillin-resistant Staphylococcus aureus and a strategy for reducing these costs on a surgical ward. Infect Control Hosp Epidemiol 2003; 24:673-678.
8. Saint S, Higgins LA, Nallamothu BK, Chenoweth C. Do physicians examine patients in contact isolation less frequently? A brief report. Am J Infect Control 2003; 31:354-356.
9. Kirkland KB, Weinstein JM. Adverse effects of contact isolation. Lancet 1999; 354:1177-1178.
10. Evans HL, Shaffer MM, Hughes MG, et al. Contact isolation in surgical patients: a barrier to care? Surgery 2003; 134:180-188.
11. Catalano G, Houston SH, Catalano MC, et al. Anxiety and depression in hospitalized patients in resistant organism isolation. South Med J 2003; 96:141-145.
12. Tarzi S, Kennedy P, Stone S, Evans M. Methicillin-resistant Staphylococcus aureus: psychological impact of hospitalization and isolation in an older adult population. J Hosp Infect 2001; 49:250-254.
13. Stelfox HT, Bates DW, Redelmeier DA. Safety of patients isolated for infection control. JAMA 2003; 290:1899-1905.
14. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39:309-317.
15. Turner PJ. Meropenem and imipenem activity against Pseudomonas aeruginosa isolates from the MYSTIC Program. Diagn Microbiol Infect Dis 2006; 56:341-344.
16. Dijkshoorn L, Nemec A, Seifert H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 2007; 5: 939-951.
17. Wenzel RP, Edmond MB. Team-based prevention of catheter-related infections. N Engl J Med 2006; 355:2781-2783.
18. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006; 355:2725-2732.
19. Wenzel RP, Edmond MB. The impact of hospital-acquired bloodstream infections. Emerg Infect Dis 2001; 7:174-177.
20. Klevens RM, Edwards JR, Richards CL Jr, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007; 122:160-166.
21. Wenzel RP. The mortality of hospital acquired bloodstream infections: need for a new vital statistic. Trans Am Clin Climatol Assoc 1987; 98:43-48.
22. Wenzel RP. Perspective: attributable mortality - the promise of better antimicrobial therapy. J Infect Dis 1998; 178:917-919.
23. Digiovine B, Chenoweth C, Watts C, Higgins M. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. Am J Respir Crit Care Med 1999; 160:976-981.
24. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infections in critically ill patients. JAMA 1994; 271:1598-1601.
25. NNIS System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32:470-485.
26. NNIS System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January through June 2003, issued August 2003. Am J Infect Control 2003; 31:481-498.
27. Obritsch MD, Fish DN, MacLaren R, Jung R. National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002. Antimicrob Agents Chemother 2004; 48:4606-4610.
28. Pfaller MA, Diekema DJ, Gibbs DL, et al. Results from the ARTEMIS DISK Global Antifungal Surveillance study, 1997 to 2005: an 8.5-year analysis of susceptibilities of Candida species and other yeast species to fluconazole and voriconazole determined by CLSI standardized disk diffusion testing. J Clin Microbiol 2007; 45:1735-1745.
29. Turner PJ. Meropenem and imipenem activity against Pseudomonas aeruginosa isolates from the MYSTIC Program. Diagn Microbiol Infect Dis 2006; 56:341-344.
30. NNIS. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992-April 2000, issued June 2000. Am J Infect Control 2000; 28:429-448.
31. Dijkshoorn L, Nemec A, Seifert H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 2007; 5: 939-951.
32. Klevens RM, Edwards JR, Tenover FC, et al. Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in U.S. hospitals, 1992-2003. Clin Infect Dis 2006; 42:389-391.
33. Edmond MB, Wallace SE, McClish DK, et al. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 1999; 29:239-241.
34. Panlilio AL, Culver DH, Gaynes RP, et al. Methicillin-resistant Staphylococcus aureus in U.S. hospitals, 1975-1991. Infect Control Hosp Epidemiol 1992; 13: 582-586.
35. Peacock JE, Marsik FJ, Wenzel RP. Methicillin-resistant Staphylococcus aureus: introduction and spread within a hospital. Ann Intern Med 1980; 93:526-532.
36. Thompson RL, Cabezudo I, Wenzel RP. Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. Ann Intern Med 1982; 97:309-317.
37. Reagan DR, Doebbeling BN, Pfaller MA, et al. Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment. Ann Intern Med 1991; 114:101-106.
38. Doebbeling BN, Reagan DR, Pfaller MA, Houston AK, Hollins RJ, Wenzel RP. Long-term efficacy of intranasal mupirocin ointment: a prospective cohort study of Staphylococcus aureus carriage. Arch Intern Med 1994; 154:1505-1508.
39. Redhead RJ, Lamb YJ, Rowsell RB. The efficacy of calcium mupirocin in the eradication of nasal Staphylococcus aureus carriage. Br J Clin Pract 1991; 45:252-254.
40. Vandenbroucke-Grauls CM, Frenay HM, van Klingeren B, Savelkoul TF, Verhoef J. Control of epidemic methicillin-resistant Staphylococcus aureus in a Dutch university hospital. Eur J Clin Microbiol Infect Dis 1991; 10: 6-11.
41. Hartstein AI, Denny MA, Morthland VH, LeMonte AM, Pfaller MA. Control of methicillin-resistant Staphylococcus aureus in a hospital and an intensive care unit. Infect Control Hosp Epidemiol 1995; 16:405-411.
42. Swabs in hand, hospital cuts deadly infections. New York Times. January 13, 2008.
43. Harbarth S, Fankhauser C, Schrenzel J, et al. Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 2008; 299:1149-1157.
44. Jayarantnam D, Whitty CJ, Phillips K, et al. Impact of rapid screening tests on acquisition of methicillin-resistant Staphylococcus aureus: cluster randomized crossover trial. BMJ 2008; 336:927-930.
45. Diekema DJ, Edmond MB. Look before you leap: active surveillance for multidrug-resistant organisms. Clin Infect Dis 2007; 44:1101-1107.
46. Edmond MB, Ober JF, Bearman G. Active surveillance cultures are not required to control MRSA infections in the critical care setting. Am J Infect Control 2008; 36:461-463.
47. Musser JM, Kapur V. Clonal analysis of methicillin-resistant Staphylococcus aureus strains from intercontinental sources: association of the mec gene with divergent phylogenetic lineages implies dissemination by horizontal transfer and recombination. J Clin Microbiol 1992; 30:2058-2063.
48. NNIS. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32:470-485.
49. McGowan JE Jr. Resistance in nonfermenting gram-negative bacteria: multidrug resistance to the maximum. Am J Infect Control 2006; 34 (Suppl 1):S29-37; discussion S64-73.
50. Edmond MB, Ober JF, Dawson J D, Weinbaum DL, Wenzel RP. Vancomycin-resistant enterococcal bacteremia: natural history and attributable mortality. Clin Infect Dis 1996; 23:1234-1240.
51. Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP. Hospital-acquired candidemia: the attributable mortality and excess length of stay. Arch Intern Med 1988; 148:2642-2647.
52. von Eiff C; Becker K; Machka K; Stammer H; Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 2001; 344: 11-16.
53. Widmer A, Mertz D, Frei R. Necessity of screening both the nose and the throat to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit. J Clin Microbiol 2008; 46:835.
54. Marshall C, Spelman D. Re: is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit? J Clin Microbiol 2007; 45:3855.
55. Zafar U, Johnson LB, Hanna M, et al. Prevalence of nasal colonization among patients with community-associated methicillin-resistant Staphylococcus aureus infection and their household contacts. Infect Control Hosp Epidemiol 2007; 28:966-969.
56. Cook HA, Furoya EY, Larson E, Vasquez G, Lowy FD. Heterosexual transmission of community-acquired methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2007; 44:410-413.
57. Muto CA, Jernigan JA, Ostrowsky BE, et al. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and Enterococcus. Infect Control Hosp Epidemiol 2003; 24:362-386.
58. Davis KA, Stewart JJ, Crouch HK, et al. Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin Infect Dis 2004; 39:776-782.
59. Datta R, Huang SS. Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long term carriers. Clin Infect Dis 2008; 47:176-181.
60. van Rijen MM, Bonten M, Wenzel RP, Kluytmans JA. Intranasal mupirocin for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic review. J Antimicrob Chemother 2008; 61:254-261.
61. Wenzel RP. The antibiotic pipeline - challenges, costs, and values. N Engl J Med 2004; 351:523-526.
62. Doebbeling BN, Stanley GL, Sheetz CT, et al. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. N Engl J Med 1992; 327:88-93.
63. Trick WE, Vernon MO, Welbel SF, et al. Multicenter intervention program to increase adherence to hand hygiene recommendations and glove use and to reduce the incidence of antimicrobial resistance. Infect Control Hosp Epidemiol 2007; 28:42-49.
64. Edmond MB, Bearman GM. Mandatory public reporting in the USA: an example to follow? J Hosp Infect 2007; 65(Suppl 2):182-188.