Knockout mice: Is it just genetics? Effect of enriched housing on fibulin-4+/2 mice

PLoS ONE

Volumn 2, Issue 2, 2007, Pages

  Cudilo, Elizabeth ^a   Al Naemi, Hamda ^b   Marmorstein, Lihua ^a   Baldwin, Ann L ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b QATAR UNIVERSITY   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBER; FIBULIN; FIBULIN 4; SCLEROPROTEIN; UNCLASSIFIED DRUG; FIBULIN-4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA DISEASE; ARTERY MEDIA; ARTERY PERFUSION; ARTICLE; CAGE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIAL DYSFUNCTION; KNOCKOUT MOUSE; MALE; MICROSCOPY; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; WILD TYPE; ANIMAL; ANIMAL HOUSING; AORTA; C57BL MOUSE; CONGENITAL MALFORMATION; CROSS BREEDING; ENVIRONMENTAL PLANNING; FIBROSIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HETEROZYGOTE; METHODOLOGY; MOTOR ACTIVITY; MOUSE MUTANT; PHYSIOLOGY; TIGHT JUNCTION; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALIA; MUS;

ANIMALS; AORTA; CROSSES, GENETIC; ENDOTHELIUM, VASCULAR; ENVIRONMENT DESIGN; EXTRACELLULAR MATRIX PROTEINS; FIBROSIS; HETEROZYGOTE; HOUSING, ANIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE, SMOOTH, VASCULAR; PHYSICAL CONDITIONING, ANIMAL; RESEARCH DESIGN; TIGHT JUNCTIONS;

EID: 54949096514     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000229     Document Type: Article

References (20)

1. Sosa-Melgaejo JA, Berry CL (1989) Contact relationships between vascular smooth muscle cells: an in vivo and in vitro study. Journal of Pathology 157: 213-217.
2. Argraves WS, Greene LM, Cooley MA, Gallagher WM (2003) Fibulins: physiological and disease perspectives. European Molecular Biology Organization 4(12): 1127-1131.
3. Roark EF, Keene DR, Haudenschild CC, Godyna S, Little CD, et al. (1995) The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study. J. Histochem. Cytochem. 43: 401-411.
4. Tsuda T, Wang H, Timpl R, Chu ML (2001) Fibulin-2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels and coronary vessels. Dev Dyn 222: 89-100.
5. McLaughlin PJ, Chen Q, Horiguchi M, Starcher BC, Stanton JB, et al. (2006) Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Molecular and Cellular Biology 26(5): 1700-1709.
6. Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M et al (2002) Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo. Nature 415: 168-171.
7. Hucthagowder V, Sausgruber N, Kim KH, Angle B, Marmorstein LY, et al. (2006) Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome. Amer. Jour. Human Genetics 78: 1075-1080.
8. Lin C-H, Nansen S, Wang Z, Storm DR, Tapscott SJ, Olson JM (2005) The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Proceedings of the National Academy of Sciences USA, 102(41): 14877-14882.
9. Chu M-L, Tsuda T (2004) Fibulins in development and heritable disease. Birth Defects Research 72: 25-36.
10. Humason GL (1979) Animal Tissue Techniques (4th ed). San Francisco: WH Freeman & Co. pp. 147-149.
11. Davis EC (1993) Endothelial cell connecting filaments anchor endothelial cells to the subjacent elastic lamina in the developing aortic intima of the mouse. Cell Tissue Research 272: 211-219.
12. Reinhardt DP, Sasaki T, Dzamba BJ, Keene DR, Chu M, et al. (1996) Fibrillin-1 and fibulin-2 interact and are co-localized in some tissues. Journal of Biological Chemistry 271(32): 19489-19496.
13. Sing CF, Stengard JH, Kardia SLR (2003) Genes, environment and cardiovascular disease. Arteriosclerosis, Thrombosis and Vascular Biology 23: 1190-1196.
14. Crabbe JC, Wahlsten D, Dudek BC (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284: 1670-1672.
15. Lazarov O, Robinson J, Tang Y-P, Hairston IS, Korade-Mirnics Z, et al. (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120(5): 701-713.
16. Spires TL, Grote HE, Varshney NK, Cordery PM, van Dellen A, et al. (2004) Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. Journal of Neuroscience 24(9): 2270-2276.
17. Restivo L, Ferrari F, Passino E, Sgobio C, Bock J, et al. (1562) Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. Proceedings of the National Academy of Sciences of the United States of America 102(32): 11557-11562.
18. Gilbert SF (2005) Mechanisms for the environmental regulation of gene expression: ecological aspects of animal development. Journal of Bioscience 30: 65-74.
19. Collod G, Chu ML, Sasaki T, Timpl M, Renkart R, et al. (1996) Fibulin-2: genetic mapping and exclusion as a candidate gene in Marfan syndrome type 2. European Journal of Human Genetics 4: 292-295.
20. Collod-Beroud G, Boileau C (2002) Marfan syndrome in the third millennium. European Journal of Human Genetics 10: 673-681.