5-ht2c receptor and mao-a interaction analysis: No association with suicidal behaviour in bipolar patients

European Archives of Psychiatry and Clinical Neuroscience

Volumn 258, Issue 7, 2008, Pages 428-433

  De Luca, Vincenzo ^a   Tharmaligam, Subi ^a   Strauss, John ^a   Kennedy, James L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 ht2c; Bipolar disorder; Haplotype; MAO A; Suicide; X linked

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; SEROTONIN 2C RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FAMILY; FEMALE; GENE INTERACTION; HAPLOTYPE; HUMAN; MALE; MENTAL PATIENT; PRIORITY JOURNAL; PROMOTER REGION; SHORT TANDEM REPEAT; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; X CHROMOSOME LINKAGE;

ADOLESCENT; ADULT; AGED; BIPOLAR DISORDER; CANADA; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENES, X-LINKED; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MONOAMINE OXIDASE; NUCLEAR FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2C; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 54949095363     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-008-0815-x     Document Type: Article

References (34)

1. APA (1994) Diagnostic and statistical manual of mental disorders, 4th edn (DSM-IV). APA, Washington, DC
2. V Arango P Ernsberger PM Marzuk JS Chen H Tierney M Stanley DJ Reis JJ Mann 1990 Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims Arch Gen Psychiatry 47 1038 1047
3. M Asberg L Traskman P Thoren 1976 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33 1193 1197
4. SS Canetto I Sakinofsky 1998 The gender paradox in suicide Suicide Life Threat Behav 28 1 23
5. YW Chen SC Dilsaver 1996 Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders Biol Psychiatry 39 896 899
6. EJ Dalton TD Cate-Carter E Mundo SV Parikh JL Kennedy 2003 Suicide risk in bipolar patients: the role of co-morbid substance use disorders Bipolar Disord 5 58 61
7. V De Luca S Tharmalingam T Sicard JL Kennedy 2005 Gene-gene interaction between MAOA and COMT in suicidal behavior Neurosci Lett 383 151 154
8. V De Luca H Wang A Squassina GW Wong J Yeomans JL Kennedy 2004 Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia Neuropsychobiology 50 124 127
9. J Deckert J Meyer M Catalano M Bosi P Sand D DiBella G Ortega G Stober P Franke MM Nothen J Fritze W Maier H Beckmann P Propping L Bellodi KP Lesch 2000 Novel 5′-regulatory region polymorphisms of the 5-HT2C receptor gene: association study with panic disorder Int J Neuropsychopharmacol 3 321 325
10. CM Drysdale DW McGraw CB Stack JC Stephens RS Judson K Nandabalan K Arnold G Ruano SB Liggett 2000 Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness Proc Natl Acad Sci USA 97 10483 10488
11. L Du G Faludi M Palkovits P Sotonyi D Bakish PD Hrdina 2002 High activity-related allele of MAO-A gene associated with depressed suicide in males Neuroreport 13 1195 1198
12. F Dudbridge 2003 Pedigree disequilibrium tests for multilocus haplotypes Genet Epidemiol 25 115 121
13. B Gutierrez B Arias S Papiol A Rosa L Fananas 2001 Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder Neurosci Lett 309 135 137
14. KR Jamison 2000 Suicide and bipolar disorder J Clin Psychiatry 61 Suppl 9 47 51
15. TE Joiner Jr JS Brown LR Wingate 2005 The psychology and neurobiology of suicidal behavior Annu Rev Psychol 56 287 314
16. DK Lahiri JI Nurnberger Jr 1991 A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies Nucleic Acids Res 19 5444
17. J Lappalainen L Zhang M Dean M Oz N Ozaki DH Yu M Virkkunen F Weight M Linnoila D Goldman 1995 Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C) Genomics 27 274 279
18. Mann JJ (1995) The fourth generation of progress. Raven Press, New York
19. JJ Mann 1998 The neurobiology of suicide Nat Med 4 25 30
20. JJ Mann DA Brent V Arango 2001 The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system Neuropsychopharmacology 24 467 477
21. P McGuffin A Marusic A Farmer 2001 What can psychiatric genetics offer suicidology? Crisis 22 61 65
22. CM Niswender K Herrick-Davis GE Dilley HY Meltzer JC Overholser CA Stockmeier RB Emeson E Sanders-Bush 2001 RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy Neuropsychopharmacology 24 478 491
23. P Nordstrom M Samuelsson M Asberg L Traskman-Bendz A Aberg-Wistedt C Nordin L Bertilsson 1994 CSF 5-HIAA predicts suicide risk after attempted suicide Suicide Life Threat Behav 24 1 9
24. M Okada JK Northup N Ozaki JT Russell M Linnoila D Goldman 2004 Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution Mol Psychiatry 9 55 64
25. EC Pooley K Houston K Hawton PJ Harrison 2003 Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes Psychol Med 33 775 783
26. A Roy 1993 Genetic and biologic risk factors for suicide in depressive disorders Psychiatr Q 64 345 358
27. E Rydin M Asberg G Edman D Schalling 1990 Violent and nonviolent suicide attempts-a controlled Rorschach study Acta Psychiatr Scand 82 30 39
28. A Serretti L Mandelli I Giegling B Schneider AM Hartmann A Schnabel K Maurer HJ Moller D Rujescu 2007 HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers Am J Med Genet B Neuropsychiatr Genet 144 291 299
29. F Sherif J Marcusson L Oreland 1991 Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims Eur Arch Psychiatry Clin Neurosci 241 139 144
30. S Stack 2000 Suicide: a 15-year review of the sociological literature. Part I: cultural and economic factors Suicide Life Threat Behav 30 145 162
31. J Stefulj A Buttner M Kubat P Zill M Balija W Eisenmenger B Bondy B Jernej 2004 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations Eur Arch Psychiatry Clin Neurosci 254 224 227
32. WHO (2005) Burden of mental and behavioural disorders: suicide
33. E Xie L Zhu L Zhao LS Chang 1996 The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant Genomics 35 551 561
34. X Yuan K Yamada S Ishiyama-Shigemoto W Koyama K Nonaka 2000 Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes Diabetologia 43 373 376