Association of polymorphisms in CASP10 and CASP8 with FEV1/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics

Clinical and Experimental Allergy

Volumn 38, Issue 11, 2008, Pages 1738-1744

  Smith, Alicia K ^a   Lange, Leslie A ^b   Ampleford, Elizabeth J ^c   Meyers, Deborah A ^c   Bleecker, Eugene R ^c   Howard, Timothy D ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; Bronchial hyperresponsiveness; CASP10; Chromosome 2q; FEV 1 FVC

Indexed keywords

ADULT; AFRICAN AMERICAN; ALLERGIC ASTHMA; ARTICLE; BRONCHUS HYPERREACTIVITY; CASE CONTROL STUDY; CASPASE 10 GENE; CASPASE 8 FADD LIKE APOPTOSIS REGULATOR GENE; CASPASE 8 GENE; CAUCASIAN; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; FORCED EXPIRATORY VOLUME; GENE; GENE CLUSTER; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AFRICAN AMERICANS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 10; CASPASE 8; CHILD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FORCED EXPIRATORY VOLUME; GENE FREQUENCY; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; VITAL CAPACITY; YOUNG ADULT;

EID: 54849438138     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03095.x     Document Type: Article

References (19)

1. Krug N, Madden J, Redington A et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996 14 : 319 26.
2. Renauld JC. New insights into the role of cytokines in asthma. J Clin Pathol 2001 54 : 577 89.
3. Maddox L, Schwartz DA. The pathophysiology of asthma. Annu Rev Med 2002 53 : 477 98.
4. Howard TD, Celedon JC. Linkage to asthma and its intermediate phenotypes. In : Postma DS, Weiss ST, eds. Genetics of asthma and chronic obstructive pulmonary disease. New York : Informa Healthcare, 2007 199 208.
5. CSGA. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 1997 15 : 389 92.
6. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population [In process citation]. Am J Hum Genet 2000 67 : 1154 62.
7. Wjst M, Fischer G, Immervoll T et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 1999 58 : 1 8.
8. Xu J, Postma DS, Howard TD et al. Major genes regulating total serum immunoglobulin E levels in families with asthma. Am J Hum Genet 2000 67 : 1163 73.
9. Koppelman G, Stine O, Xu J et al. Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol 2002 109 : 498 506.
10. Postma DS, Meyers DA, Jongepier H, Howard TD, Koppelman GH, Bleecker ER. Genome wide screen for pulmonary function in 200 families ascertained for asthma. Am J Respir Crit Care Med 2005 172 : 446 52.
11. Silverman EK, Mosley JD, Palmer LJ et al. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet 2002 70 : 1229 39.
12. Wang J, Zheng L, Lobito A et al. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 1999 98 : 47 58.
13. Shin MS, Kim HS, Kang CS et al. Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas. Blood 2002 99 : 4094 9.
14. Lester LA, Rich SS, Blumenthal MN et al. Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma. J Allergy Clin Immunol 2001 108 : 357 62.
15. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005 21 : 263 5.
16. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002 70 : 425 34.
17. Gabriel SB, Schaffner SF, Nguyen H et al. The structure of haplotype blocks in the human genome. Science 2002 296 : 2225 9.
18. Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity. Am Rev Respir Dis 1980 12 : 389 413.
19. Rijcken B, Weiss ST. Longitudinal analyses of airway responsiveness and pulmonary function decline. Am J Respir Crit Care Med 1996 154 : S246 S249.