Association of Sp3 and estrogen receptor α with the transcriptionally active trefoil factor 1 promoter in MCF-7 breast cancer cells

Journal of Cellular Biochemistry

Volumn 105, Issue 2, 2008, Pages 365-369

  Li, Lin ^a   Davie, James R ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Chromatin immunoprecipitation; Estrogen receptor; Sp1; Sp3; Trefoil factor 1 gene

Indexed keywords

ESTROGEN RECEPTOR ALPHA; RNA POLYMERASE II; SERINE; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TREFOIL FACTOR 1; TREFOIL PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

BREAST NEOPLASMS; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

LOTUS;

EID: 54849421330     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21832     Document Type: Article

References (19)

1. Abdelrahim M, Samudio I, Smith R III, Burghardt R, Safe S. 2002. Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen- induced gene expression and cell cycle progression in MCF-7 breast cancer cells. J Biol Chem 277:28815-28822.
2. Castro-Rivera E, Samudio I, Safe S. 2001. Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. J Biol Chem 276:30853-30861.
3. Dubik D, Shiu RP. 1992. Mechanism of estrogen activation of c-myc oncogene expression. Oncogene 7:1587-1594.
4. Espino PS, Li L, He S, Yu J, Davie JR. 2006. Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway. Cancer Res 66:4610-4616.
5. He S, Sun JM, Li L, Davie JR. 2005. Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell 16:4073-4083.
6. Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S. 2006. Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Endocrinology 147:3285-3295.
7. Hutchison CJ. 2002. Lamins: Building blocks or regulators of gene expression? Nat Rev Mol Cell Biol 3:848-858.
8. Khan S, Wu F, Liu S, Wu Q, Safe S. 2007. Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. J Mol Endocrinol 39:289-304.
9. Li L, Sun J-M, Davie JR. 2004. Gene regulation by Sp1 and Sp3. Biochem Cell Biol 82:460-471.
10. Metivier R, Penot G, Hubner MR, Reid G, Brand H, Kos M, Gannon F. 2003. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115:751-763.
11. Prest SJ, May FE, Westley BR. 2002. The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells. FASEB J 16:592-594.
12. Rodrigues S, Van Aken E, Van Bocxlaer S, Attoub S, Nguyen QD, Bruyneel E, Westley BR, May FE, Thim L, Mareel M, Gespach C, Emami S. 2003. Trefoil peptides as proangiogenic factors in vivo and in vitro: Implication of cyclooxygenase-2 and EGF receptor signaling. FASEB J 17:7-16.
13. Sapetschnig A, Koch F, Rischitor G, Mennenga T, Suske G. 2004. Complexity of translationally controlled transcription factor Sp3 isoform expression. J Biol Chem 279:42095-42105.
14. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M. 2000. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852.
15. Spencer VA, Sun JM, Li L, Davie JR. 2003. Chromatin immunoprecipitation: A tool for studying histone acetylation and transcription factor binding. Methods 31:67-75.
16. Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR. 2002. The transcriptional repressor Sp3 is associated with CK2 phosphorylated histone deacetylase 2. J Biol Chem 277:35783-35786.
17. Sun J-M, Spencer VA, Li L, Chen HY, Yu J, Davie JR. 2005. Estrogen-regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins. Exp Cell Res 302:96-107.
18. Xie SQ, Martin S, Guillot PV, Bentley DL, Pombo A. 2006. Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain. Mol Biol Cell 17:1723-1733.
19. Yu B, Datta PK, Bagchi S. 2003. Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res 31:5368-5376.