Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats

European Surgical Research

Volumn 42, Issue 1, 2008, Pages 11-16

  Alatsakis, M ^a   Ballas, K D ^a   Pavlidis, T E ^a   Psarras, K ^a   Rafailidis, S ^a   Tzioufa Asimakopoulou, V ^a   Marakis, G N ^a   Sakantamis, A K ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Carbon tetrachloride; Esophageal varices; Hepatic cirrhosis; Portal hypertension; Propranolol

Indexed keywords

CARBON TETRACHLORIDE; PHENOBARBITAL; PLACEBO; PROPRANOLOL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCITES; CONTROLLED STUDY; DEVASCULARIZATION; DISEASE COURSE; DRUG EFFECT; ESOPHAGUS VARICES; HEMODYNAMICS; KIDNEY VEIN; LIVER CIRRHOSIS; LOWER ESOPHAGUS SPHINCTER; MALE; MORPHOMETRICS; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT;

ANIMALS; CARBON TETRACHLORIDE; ESOPHAGEAL AND GASTRIC VARICES; HYPERTENSION, PORTAL; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; PORTAL PRESSURE; PROPRANOLOL; RATS; RATS, WISTAR;

EID: 54849405229     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000166165     Document Type: Article

References (28)

1. Gupta T, Chen L, Groszmann RJ: Pathophysiology of portal hypertension. Clin Gastroenterol 1997;11:203-220.
2. Paquet KJ: Causes and pathomechanisms of oesophageal varices development. Med Sci Monit 2000;6:915-928.
3. Groszmann RJ, Abraldes JG: Portal hypertension: from bedside to bench. J Clin Gastroenterol 2005;39:S125-S130.
4. Angelico M, Carli L, Piat C, Gentile S, Capocaccia L: Isosorbide-5-mononitrate versus propranolol in the prevention of first bleeding and long-term survival in cirrhosis. Gastroenterology 1997;113:1632-1639.
5. Poynard T, Cales P, Pasta L: Beta adrenergic antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices. N Engl J Med 1991;324:1532-1538.
6. Lin HC, Soubrane O, Cailmail S, Lebrec D: Early chronic administration of propranolol reduces the severity of portal hypertension and portal systemic shunting in conscious portal vein stenosed rats. J Hepatol 1991;13:213-219.
7. Sarin SK, Groszmann RJ, Mosca PG: Propranolol ameliorates the development of portal systemic shunting in a chronic murine schistosomiasis model of portal hypertension. J Clin Invest 1991;87:1032-1036.
8. Groszmann RJ, Garcia-Tsao G, Bosch J, Grace ND, Burroughs AK, Planas R, Escorcell A, Garcia-Pagan JC, Patch D, Matloff DS, Gao H, Makuch R, Portal Hypertension Collaborative Group: Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005;353:2254-2261.
9. Ballas KD, Tzioufa-Asimakopoulou V, Marakis G, Alatsakis MB, Papavasiliou AV, Rafailidis S, Sakadamis AK: Effect of early octreotide administration on the development of esophageal varices in cirrhotic rats. Hepatol Res 2004;29:104-112.
10. B receptor antagonist, in portal hypertensive rats. Hepatology 1998;28:655-659.
11. Reichen J, Gerbes AL, Steiner MJ, Saegesser H, Clozel M: The effect of endothelin and its antagonist bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver. J Hepatol 1998;28:1020-1030.
12. Sakadamis A, Ballas K, Tzioufa-Asimakopoulou V, Alatsakis M: A rat model of liver cirrhosis and esophageal varices. Res Exp Med 2001;200:137-154.
13. Karalis M, Pavlidis TE, Psarras K, Ballas K, Zaraboukas T, Rafailidis S, Symeonidis N, Marakis GN, Sakantamis AK: Effect of experimentally induced liver cirrhosis on wound healing of the post-extraction tooth socket in rats. Eur Surg Res 2008;40:190-196.
14. Proctor E, Chatamra K: High yield micronodular cirrhosis in the rat. Gastroenterology 1982;83:1183-1190.
15. Proctor E, Chatamra K: Standardized micronodular cirrhosis in the rat. Eur Surg Res 1984;16:182-186.
16. Lee FY, Wang SS, Tsai YT, Chang FY, Lin HC, Hou MC, Chu CJ, Wu SL, Tai CC, Lee SD: Hemodynamic studies and esophageal morphometric analyses in portal hypertensive rats with adrenal vein ligation. Scand J Gastroenterol 1997;32:725-730.
17. Sarin SK, Stadeker M, Groszmann RJ: Propranolol prevents the development of portal systemic shunting in chronic murine schistosomiasis. Gastroenterology 1989;96:A654.
18. Ruthardt FW, Stauber RE, Kuhlen R, Ban Thiel DH: Chronic beta blockade reduces portal systemic shunting in portal hypertensive rats. Gastroenterology 1990;98:A199.
19. Lin H, Soubrane O, Lebrec D: Prevention of portal hypertension and portosystemic shunts by early chronic administration of clonidine in conscious portal vein stenosed rats. Hepatology 1991;14:325-330.
20. Debaene B, Goldfarb G, Braillon A: Effects of ketamine, halothane, enflurane and isoflurane on systemic and splanchnic hemodynamics in normovolemic and hypovolemic cirrhotic rats. Anesthesiology 1990;73:118-124.
21. Zimpfer M, Manders WT, Barger AC, Vatner SF: Pentobarbital alters compensatory neural and humoral mechanisms in response to hemorrhage. Am J Physiol 1982;243:713-721.
22. Lee SS, Hadengue A, Girod C, Lebrec D: Discrepant responses to betaxolol in conscious and anaesthetized portal hypertensive rats. Hepatology 1986;3:S139.
23. Jenkins SA, Baxter JN, Shields R: The effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the cirrhotic rat. Br J Surg 1985;72:864-867.
24. Jenkins SA, Baxter JN, Corbett WA: Effects of somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man. Br J Surg 1985;72:1009-1012.
25. Jenkins SA, Baxter JN, Corbett WA: A prospective randomized controlled clinical trial comparing somatostain and vasopressin in controlling acute variceal haemorrhage. Br Med J 1985;290:275-278.
26. Sonnenburg GE, Keller U, Perruchud A: Effects of somatostatin on splanchnic hemodynamics. Gastroenterology 1981;80:5226-5232.
27. Merkel C, Gatta A, Zuin R: Effect of somatostatin on splanchnic hemodynamics in patients with liver cirrhosis and portal hypertension. Digestion 1985;32:92-98.
28. Tanoue E, Kitano S, Sugimachi K: A rat model of esophageal varices. Hepatology 1991;13:353-358.