Effects of acid-base imbalance on vascular reactivity

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 6, 2008, Pages 439-445

  Celotto, A C ^a   Capellini, V K ^a   Baldo, C F ^a   Dalio, M B ^a   Rodrigues, A J ^a   Evora, P R B ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Acid base balance; Acidosis; Alkalosis; Endothelium; Nitric oxide; Vascular reactivity

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BICARBONATE CHLORIDE ANTIPORTER; BICARBONATE SODIUM COTRANSPORTER; CALCIUM CHANNEL; CARBON DIOXIDE; CYCLIC AMP; CYCLIC GMP; NITRIC OXIDE; OXYGEN; PROSTACYCLIN; PROTON; SODIUM PROTON EXCHANGE PROTEIN;

ACID BASE BALANCE; ARTERIAL PH; BLOOD FLOW; BLOOD PH; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CELL COMPARTMENTALIZATION; CHANNEL GATING; CONCENTRATION (PARAMETERS); CORONARY ARTERY BLOOD FLOW; DISORDERS OF ACID BASE BALANCE; EXCITATION CONTRACTION COUPLING; EXTRACELLULAR SPACE; HUMAN; HYPERCAPNIA; HYPERPOLARIZATION; INTRACELLULAR SPACE; ISOLATED HEART; LUNG BLOOD VESSEL; MEDICAL RESEARCH; METABOLIC ACIDOSIS; METABOLIC ALKALOSIS; NONHUMAN; PULMONARY HYPERTENSION; RESPIRATORY ACIDOSIS; RESPIRATORY ALKALOSIS; REVIEW; SCIENTIFIC LITERATURE; SMOOTH MUSCLE TONE; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ACID-BASE EQUILIBRIUM; ACIDOSIS; ALKALOSIS; ANIMALS; BLOOD VESSELS; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; HUMANS; HYDROGEN-ION CONCENTRATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; VASODILATION;

EID: 54749109902     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008005000026     Document Type: Review

References (54)

1. Smith GL, Austin C, Crichton C, Wray S. A review of the actions and control of intracellular pH in vascular smooth muscle. Cardiovasc Res 1998; 38: 316-331.
2. Ellis D, Thomas RC. Direct measurement of the intracellular pH of mammalian cardiac muscle. J Physiol 1976; 262: 755-771.
3. Aickin CC. Direct measurement of intracellular pH and buffering power in smooth muscle cells of guinea-pig vas deferens. J Physiol 1984; 349: 571-585.
4. Austin C, Wray S. Extracellular pH signals affect rat vascular tone by rapid transduction into intracellular pH changes. J Physiol 1993; 466: 1-8.
5. Franco-Cereceda A, Kallner G, Lundberg JM. Capsazepine-sensitive release of calcitonin gene-related peptide from C-fibre afferents in the guinea-pig heart by low pH and lactic acid. Eur J Pharmacol 1993; 238: 311-316.
6. Aalkjaer C, Poston L. Effects of pH on vascular tension: which are the important mechanisms? J Vasc Res 1996; 33: 347-359.
7. Ishizaka H, Kuo L. Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle. Circ Res 1996; 78: 50-57.
8. You JP, Wang Q, Zhang W, Jansen-Olesen I, Paulson OB, Lassen NA, et al. Hypercapnic vasodilatation in isolated rat basilar arteries is exerted via low pH and does not involve nitric oxide synthase stimulation or cyclic GMP production. Acta Physiol Scand 1994; 152: 391-397.
9. Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1995; 1: 804-809.
10. Giannella E, Mochmann HC, Levi R. Ischemic preconditioning prevents the impairment of hypoxic coronary vasodilatation caused by ischemia/ reperfusion: role of adenosine A1/A3 and bradykinin B2 receptor activation. Circ Res 1997; 81: 415-422.
11. Aalkjaer C, Cragoe EJ Jr. Intracellular pH regulation in resting and contracting segments of rat mesenteric resistance vessels. J Physiol 1988; 402: 391-410.
12. Aalkjaer C, Mulvany MJ. Effect of changes in intracellular pH on the contractility of rat resistance vessels. Prog Biochem Pharmacol 1988; 23: 150-158.
13. Aickin CC. Regulation of intracellular pH in smooth muscle cells of the guinea-pig femoral artery. J Physiol 1994; 479 (Part 2): 331-340.
14. Aalkjaer C, Peng HL. pH and smooth muscle. Acta Physiol Scand 1997; 161: 557-566.
15. + antiporter in vascular smooth muscle cells in culture. Kidney Int 1994; 45: 66-75.
16. 3 exchange in A10 vascular smooth muscle cells. Pflugers Arch 1988; 412: 29-36.
17. Wakabayashi I, Poteser M, Groschner K. Intracellular pH as a determinant of vascular smooth muscle function. J Vasc Res 2006; 43: 238-250.
18. Clancy RL, Gonzalez NC. Effect of respiratory and metabolic acidosis on coronary vascular resistance (38528). Proc Soc Exp Biol Med 1975; 148: 307-311.
19. Ely SW, Sawyer DC, Scott JB. Local vasoactivity of oxygen and carbon dioxide in the right coronary circulation of the dog and pig. J Physiol 1982; 332: 427-439.
20. Gurevicius J, Salem MR, Metwally AA, Silver JM, Crystal GJ. Contribution of nitric oxide to coronary vasodilation during hypercapnic acidosis. Am J Physiol 1995; 268: H39-H47.
21. 2 tensions. Am J Physiol 1990; 258: H1049-H1054.
22. Kelm M, Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res 1990; 66: 1561-1575.
23. Kostic MM, Petronijevic MR, Jakovljevic VL. Role of nitric oxide (NO) in the regulation of coronary circulation. Physiol Res 1996; 45: 273-278.
24. Song D, O'Regan MH, Phillis JW. Role of nitric oxide in rat coronary flow regulation during respiratory and metabolic acidosis. Gen Pharmacol 1999; 32: 571-575.
25. Fineman JR, Wong J, Soifer SJ. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr Res 1993; 33: 341-346.
26. Halla TR, Madden JA, Gordon JB. Mediators of alkalosis-induced relaxation of piglet pulmonary veins. Am J Physiol Lung Cell Mol Physiol 2000; 278: L968-L973.
27. Gordon JB, Halla TR, Fike CD, Madden JA. Mediators of alkalosis-induced relaxation in pulmonary arteries from normoxic and chronically hypoxic piglets. Am J Physiol 1999; 276: L155-L163.
28. (2+)-dependent modulators mediate alkalosis-induced vasodilation in newborn piglet lungs. Am J Physiol Lung Cell Mol Physiol 2001; 280: L519-L526.
29. Gordon JB, VanderHeyden MA, Halla TR, Cortez EP, Hernandez G, Haworth ST, et al. What leads to different mediators of alkalosis-induced vasodilation in isolated and in situ pulmonary vessels? Am J Physiol Lung Cell Mol Physiol 2003; 284: L799-L807.
30. Hammerman C, Aramburo MJ. Effects of hyperventilation on prostacyclin formation and on pulmonary vasodilation after group B beta-hemolytic streptococci-induced pulmonary hypertension. Pediatr Res 1991; 29: 282-287.
31. Yamaguchi K, Takasugi T, Fujita H, Mori M, Oyamada Y, Suzuki K, et al. Endothelial modulation of pH-dependent pressor response in isolated perfused rabbit lungs. Am J Physiol 1996; 270: H252-H258.
32. Gao Y, Tassiopoulos AK, McGraw DJ, Hauser MC, Camporesi EM, Hakim TS. Segmental pulmonary vascular responses to changes in pH in rat lungs: role of nitric oxide. Acta Anaesthesiol Scand 1999; 43: 64-70.
33. 2+ of prostacyclin synthesis in rat aortic rings: effects of drugs and inorganic ions. Br J Pharmacol 1987; 91: 439-446.
34. Gaskell WH. On the tonicity of the heart and blood vessels. J Physiol 1880; 3: 48-92.
35. Zsoter T, Banderman L, Chappel CI. The effect of "local" pH changes on blood flow in the dog. Am Heart J 1961; 61: 777-782.
36. Dusting GJ, Rand MJ. Interactions between the hydrogen ion concentration and vasoconstrictor responses to catecholamines and sympathetic nerve stimulation. Clin Exp Pharmacol Physiol 1975; Suppl 2: 43-48.
37. Kohlhardt M, Haap K, Figulla HR. Influence of low extracellular pH upon the Ca inward current and isometric contractile force in mammalian ventricular myocardium. Pflugers Arch 1976; 366: 31-38.
38. Fabiato A, Fabiato F. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J Physiol 1978; 276: 233-255.
39. Flavahan NA, McGrath JC. Alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart. Br J Pharmacol 1981; 73: 586-588.
40. Rooke TW, Sparks HV Jr. Effect of metabolic versus respiratory acid-base changes on isolated coronary artery and saphenous vein. Experientia 1981; 37: 982-983.
41. + current in freshly dispersed cerebral arterial muscle cells. Pflugers Arch 1991; 418: 292-296.
42. 2 on agonist-induced contractility of rat aorta. Am J Physiol 1993; 264: H512-H519.
43. Hattori K, Tsuchida S, Tsukahara H, Mayumi M, Tanaka T, Zhang L, et al. Augmentation of NO-mediated vasodilation in metabolic acidosis. Life Sci 2002; 71: 1439-1447.
44. Horiuchi T, Dietrich HH, Hongo K, Goto T, Dacey RG Jr. Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis. Stroke 2002; 33: 844-849.
45. Modin A, Bjorne H, Herulf M, Alving K, Weitzberg E, Lundberg JO. Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation. Acta Physiol Scand 2001; 171: 9-16.
46. Demirel E, Laskey RE, Purkerson S, van Breemen C. The passive calcium leak in cultured porcine aortic endothelial cells. Biochem Biophys Res Commun 1993; 191: 1197-1203.
47. Rohra DK, Sharif HM, Zubairi HS, Sarfraz K, Ghayur MN, Gilani AH. Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels. Eur J Pharmacol 2005; 514: 175-181.
48. Kinsella JP, Abman SH. Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn. J Pediatr 1995; 126: 853-864.
49. Nagy S, Harris MB, Ju H, Bhatia J, Venema RC. pH and nitric oxide synthase activity and expression in bovine aortic endothelial cells. Acta Paediatr 2006; 95: 814-817.
50. Lyrene RK, Welch KA, Godoy G, Philips JB III. Alkalosis attenuates hypoxic pulmonary vasoconstriction in neonatal lambs. Pediatr Res 1985; 19: 1268-1271.
51. 2, attenuates hypoxia-induced pulmonary vasoconstriction in newborn lambs. Pediatr Res 1986; 20: 113-117.
52. Mizuno S, Demura Y, Ameshima S, Okamura S, Miyamori I, Ishizaki T. Alkalosis stimulates endothelial nitric oxide synthase in cultured human pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 2002; 283: L113-L119.
53. Yoon SH, Zuccarello M, Rapoport RM. Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis. Gen Pharmacol 2000; 35: 325-332.
54. 2+]c in piglet cerebrovascular smooth muscle. Proc Soc Exp Biol Med 1998; 219: 226-234.