Thrombin specificity: Further evidence for the importance of the β- insertion loop and Trp96. Implications of the hydrophobic interaction between Trp96 and Pro(60b) Pro(60c) for the activity of thrombin

Journal of Protein Chemistry

Volumn 17, Issue 3, 1998, Pages 197-208

  DiBella, Elsie E ^a,b   Scheraga, Harold A ^a  

^a Cornell University ^*  (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

insertion loop; Mutants; Structure activity relationship; Thrombin

Indexed keywords

ANILINE DERIVATIVE; APROTININ; ASPARTIC ACID; DEXTRO PHENYLALANYLPIPECOLYLARGININE 4 NITROANILINE; FIBRINOGEN; GLYCINE; LYSINE; MUTANT PROTEIN; PROLINE; RECOMBINANT PROTEIN; SERINE; THROMBIN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; HYDROLYSIS; HYDROPHOBICITY; MICHAELIS CONSTANT; NONHUMAN; POINT MUTATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION;

FIBRINOGEN; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBIN; TRYPSIN; TRYPTOPHAN;

EID: 54749102266     PISSN: 02778033     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022524416221     Document Type: Article

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