Effect of extracellular matrix on gene expression and mRNA stability in primary rat hepatocytes

Journal of Toxicologic Pathology

Volumn 11, Issue 4, 1998, Pages 219-227

  Benn, Sally J ^a   Allan, Alison ^a   Laithwaite, James E ^a   Tsukamoto, Yasuhiro ^b   Yamate, Jyoji ^b   Kirby, Gordon ^a   LaMarre, Jonathan ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b Osaka Prefecture University   (Japan)

Author keywords

1. Abbreviations used in this paper : LRF 1; Liver regeneration factor 1; CEBP , CCAAT enhancer binding protein delta; DRB 5, 6 dichloro l ribofuranosyl benzimidazole; LRP

Indexed keywords

EID: 54649084341     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.11.219     Document Type: Article

References (57)

1. Alam T, An MR, and Papaconstantinou J: Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J Biol Chem 1992 ; 267(8) : 50215024.
2. Baimain A, Krumlauf R, Vass JK, and Birnie GD : Cloning and characterization of the abundant cytoplasmic 7S RNA from mouse cells. Nucleic Acids Res 1982 ; 10 : 4259-4277.
3. Ben-Ze'ev A, Robinson OS, Bucher NL, and Farmer SR : Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci USA 1988 ; 85(7) : 2161-2165.
4. Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JI, Landschulz WH, and McKnight SL : Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 1989 ; 3(8) : 1146-1156.
5. Bissell DM and Guzelian PS : Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Ann NY Acad Sci 1980 ; 349 : 85-98.
6. Bissell DM, Caron JM, Babiss LE, and Friedman JM : Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix. Mol Biol Med 1990 ; 7(2) : 187-197.
7. Brown SE, Guzelian CP, Schuetz E, Quattrochi LC, Kleinman HK, and Guzelian PS : Critical role of extracellular matrix on induction by phénobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes. Lab Invest 1995 ; 73(6) : 818-827.
8. Caron JM : Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins. Mol Cell Biol 1990 ; 10 : 1239-1243.
9. Carr BI, Hayashi I, Branum EL, and Moses H L : Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor. Cancer Res 1986 ; 46(5) : 23302334.
10. Clouthier DE, Comerford SA, and Hammer RE : Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-betal transgenic mice. J Clin Invest 1997 ; 100(11) : 2697-2713.
11. Diehl AM and Yang SQ : Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/ EBP site in the c-fos promoter. Hepatology 1994 ; 19(2) : 447-456.
12. DiPersio CM, Jackson DA, and Zaret KS : The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol Cell Biol 1991 ; 11 : 44054414.
13. Fausto N and Mead JE: Regulation of liver growth: protooncogenes and transforming growth factors. Lab Invest 1989 ; 60(1) : 4-13.
14. Flodby P, Antonson P, Barlow C, Blanck A, Porsch-Hallstrom I, and Xanthopoulos KG : Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats. Exp Cell Res 1993 ; 208(1) : 248-256.
15. Friedman JM, Chung EY, and Darnell JE Jr : Gene expression during liver regeneration. J Mol Biol 1984 ; 179(1) : 3753.
16. George J, Goodwin B, Liddle C, Tapner M, and Farrell GC : Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes. J Lab Clin Med 1997 ; 129(6) : 638-648.
17. Greenbaum LE, Cressman DE, Haber BA, and Taub R : Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth. J Clin Invest 1995 ; 96(3) : 1351-1365.
18. Haber BA, Mohn KL, Diamond RH, and Taub R : Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration. Clin Invest 1993 ; 91(4) : 1319-1326.
19. Hansen LK, Mooney DJ, Vacanti JP, and Ingber DE : Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol Biol Cell 1994 ; 5(9) : 967-975.
20. Higgins GM and Anderson RM : Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931 ; 12 : 186-202.
21. Jones DE Jr, Tran-Patterson R, Cui DM, Davin D, Estell KP, and Miller DM : Epidermal growth factor secreted from the salivary gland is necessary for liver regeneration. Am J Physiol 1995 ; 268(5 Pt 1) : G872-G878.
22. Kato S, Otsu K, Ohtake K, Kimura Y, Yashiro T, Suzuki T, and Akamatsu H : Concurrent changes in sinusoidal expression of laminin and affinity of hepatocytes to laminin during rat liver regeneration. Exp Cell Res 1992 ; 198(1) : 59-68.
23. Kimura M and Ogihara M : Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents. Eur J Pharmacol 1997 ; 324(2-3) : 267-276.
24. Kocarek TA, Schuetz EG, and Guzelian PS : Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel. Mol Pharmacol 1993 ; 43(3) : 328-334.
25. Kogure K, Omata W, Kanzaki M, Zhang YQ, Yasuda H, Mine T, and Kojima I : A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats. Gastroenterology 1995 ; 108(4) : 1136-1142.
26. Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson N, Bottinger EP, Klotman PE, and Thorgeirsson SS : Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest 1996 ; 74(6) : 991-1003.
27. Kren BT and Steer CJ : Posttranscriptional regulation of gene expression in liver regeneration : role of mRNA stability. FASEBJ 1996 ; 10(5) : 559-573.
28. Lilja H, Blanc P, Demetriou AA, and Rozga J : Response of cultured fetal and adult rat hepatocytes to growth factors and cyclosporine. Cell Transplant 1998 ; 7(3) : 257-266.
29. Lin CQ and Bisseil MJ : Multi-faceted regulation of cell differentiation by extracellular matrix. FASEB J 1993 ; 7(9) : 737-743.
30. Lindroos PM, Zarnegar R, and Michalopoulos GK : Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 1991 ; 13(4) : 743-750.
31. Liu ML, Mars WM, Zarnegar R, and Michalopoulos GK : Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-alpha in adult rat liver. Hepatology 1994 ; 19(6) : 1521-1527.
32. Mars WM, Kim TH, Stolz DB, Liu ML, and Michalopoulos GK : Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res 1996 ; 56(12) : 2837-2843.
33. Matsuda Y, Matsumoto K, Yamada A, Ichida T, Asakura H, Komoriya Y, Nishiyama E, and Nakamura T : Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis. Hepatology 1997 ; 26(1) : 81-89.
34. Mesa ML, Carrizosa R, Martinez-Honduvilla C, Benito M, and Fabregat I: Changes in rat liver gene expression induced by thioacetamide : protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism. Hepatology 1996 ; 23(3) : 600-606.
35. Michalopoulos GK : Liver regeneration : molecular mechanisms of growth control. FASEB J 1990 ; 4(2) : 176-187.
36. Michalopoulos GK and DeFrances MC : Liver regeneration. Science 1997 ; 276(5309) : 60-66.
37. Mischoulon D, Rana B, Bucher NL, and Farmer SR : Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Mol Cell Biol 1992 ; 12(6) : 2553-2560.
38. Mooney D, Hansen L, Vacanti J, Langer R, Farmer S, and Ingber D : Switching from differentiation to growth in hepatocytes : control by extracellular matrix. Cell Physiol 1992 ; 151(3) : 497-505.
39. Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R, and Dedhar S : Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci USA 1998 ; 95(8) : 4374-4379.
40. Padgham CRW, Boyle CC, Wang X-J, Raleigh SM, Wright MC, and Paine AJ : Alteration of transcription factor mRNAs during the isolation and culture of rat hepatocytes suggests the activation of a proliferative mode underlies their dedifferentiation. Biochem Biophys Res Comm 1993 ; 197 : 599-604.
41. Pierce A, Lyon M, Hampson IN, Cowling GJ, and Gallagher JT : Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver. J Biol Chem 1992 ; 267(6) : 3894-3900.
42. Ponder KP : Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies. FASEB J 1996 ; 10(7) : 673-682.
43. Rana B, Mischoulon D, Xie Y, Bucher NL, and Farmer SR : Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes : reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Mol Cell Biol 1994 ; 14(9) : 5858-5869.
44. Roos F, Ryan AM, Chamow SM, Bennett GL, and Schwall RH : Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am J Physiol 1995 ; 268(2 Pt 1) : G380-G386.
45. Ross J : Control of messenger RNA stability in higher eukaryotes. Trends Genet 1996 ; 12(5) : 171-175.
46. Rubin RA, O'Keefe EJ, and Earp HS : Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration. Proc Natl Acad Sci USA 1982 ; 79(3) : 776780.
47. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, Sporn MB, and Thorgeirsson SS : Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 1995 ; 92(7) : 2572-2576.
48. Schmoelzl S, Benn SJ, Laithwaite JE, Greenwood SJ, Marshall WS, Munday NA, Fitzgerald DJ, and LaMarre J : Expression of Hepatocyte Low Density Lipoprotein Receptor-Related Protein is Post-transcriptionally Regulated by Extracellular Matrix. Lab Invest 1998 ; 78 : 1-9.
49. Schuetz EG, Li, D, Omiecinski CJ, Muller-Eberhard U, Kleinmann HK, Elswick B, and Guzelian PS : Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol 1988 ; 134 : 309-323.
50. Taub R : Liver regeneration 4 : transcriptional control of liver regeneration. FASEB J 1996 ; 10(4) : 413-427.
51. Thornton AJ, Brudzinski CJ, Raper SE, and Gelehrter TD : Plasminogen activator inhibitor-1 is an immediate early response gene in regenerating rat liver. Cancer Res 1994 ; 54 : 1337-1343.
52. Tomiya T, Tani M, Yamada S, Hayashi S, Umeda N, and Fujiwara K : Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients. Gastroenterology 1992 ; 103(5) : 1621-1624.
53. Tsuda M, Matozaki T, Fukunaga K, Fujioka Y, Imamoto A, Noguchi T, Takada T, Yamao T, Takeda H, Ochi F, Yamamoto T, Kasuga M : Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. J Biol Chem 1998 ; 273(21) : 13223-13229.
54. Watanabe Y, Osaki H, and Akaike T: TNF-alpha bifunctionally induces proliferation in primary hepatocytes : role of cell anchorage and spreading. Immunol 1997 ; 159(10) : 4840-4847.
55. Webber EM, FitzGerald MJ, Brown PI, Bartlett MH, and Fausto N : Transforming growth factor-alpha expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-alpha and hepatocyte growth factor. Hepatology 1993 ; 18(6) : 1422-1431.
56. Webber EM, Godowski PJ, and Fausto N : In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 1994 ; 19(2) : 489-497.
57. Weir E, Chen Q, DeFrancesm MC, Bell A, and Taub R, Zarnegar R : Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor. Hepatology 1994 ; 20(4 Pt 1) : 955-960.