Can the fractional excretion of uric acid distinguish the etiology of hyponatremia in patients taking diuretics?

Nature Clinical Practice Endocrinology and Metabolism

Volumn 4, Issue 11, 2008, Pages 602-603

  Steinman, Theodore I ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Diuretic; Hyponatremia; Syndrome of inappropriate antidiuretic hormone; Urinary sodium; Volume status

Indexed keywords

DIURETIC AGENT; SULFINPYRAZONE; URIC ACID; URICOSURIC AGENT;

DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; GLOMERULUS FILTRATION RATE; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; KIDNEY CLEARANCE; NOTE; PRIORITY JOURNAL; SODIUM URINE LEVEL; URIC ACID URINE LEVEL;

EID: 54549123333     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0973     Document Type: Note

References (7)

1. Fenske W et al. (2008) Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab 93: 2991-2997
2. Decaux G et al. (1985) Mechanisms of hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. Nephron 39: 164-168
3. Milionis HJ et al. (2002) The hyponatremic patient: a systemic approach to laboratory diagnosis. CMAJ 166: 1056-1062
4. Liamis G et al. (2007) Uric acid homeostasis in the evaluation of diuretic-induced hyponatremia. J Investig Med 55: 36-44
5. Decaux G et al. (1994) Uric acid, anion gap and urea concentration in the diagnostic approach to hyponatremia. Clin Nephrol 42: 102-108
6. Decaux G et al. (2000) Evidence that chronicity of hyponatremia contributes to the high urate clearance observed in the syndrome of inappropriate antidiuretic hormone secretion. Am J Kidney Dis 36: 745-751
7. Sonnenblick M et al. (1988) Increased uric acid clearance in the syndrome of inappropriate secretion of antidiuretic hormone. Isr J Med Sci 24: 20-23