The endothelium secretes interleukin-6 (IL-6) and induces IL-6 and aldosterone generation by adrenocortical cells

Experimental and Clinical Endocrinology and Diabetes

Volumn 116, Issue SUPPL. 1, 2008, Pages

  Willenberg, Holger S ^a   Ansurudeen, I ^b   Schebesta, K ^a   Haase, M ^a   Wess, B ^a   Schinner, S ^a   Raffel, A ^a   Schott, M ^a   Scherbaum, W A ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Adrenal; Aldosterone; Endothelium; Hypertension; Interleukin 6

Indexed keywords

ALDOSTERONE; INTERLEUKIN 6;

ADRENAL CORTEX CELL; ALDOSTERONE RELEASE; ARTICLE; CANCER CELL CULTURE; CELL SECRETION; CELL STRAIN; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ADRENAL CORTEX; ALDOSTERONE; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; ENDOTHELIUM, VASCULAR; GENES, REPORTER; HUMANS; INTERLEUKIN-6; PARACRINE COMMUNICATION; TRANSFECTION;

EID: 54549116906     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081497     Document Type: Article

References (23)

1. Ansurudeen I, Kopprasch S, Ehrhart-Bornstein M, Willenberg HS, Funk RHW, Krug AW, Bornstein SR. Vascular-adrenal niche - endothelial cell-mediated sensitization of human adrenocortical cells to angiotensin II. Horm Metab Res 2006; 38: 476-480
2. Ansurudeen I, Kopprasch S, Ehrhart-Bornstein M, Bornstein SR, Willenberg HS. Endothelial cell-mediated regulation of aldosterone release from human adrenocortical cells. Mol Cell Endocrinol 2007; 265-266: 150-156
3. Barney M, Call GB, MacIlmoil CJ, Husein OF, Adams A, Balls AG, Oliveira GK, Miner EC, Richards TA, Crawford BK, Heckmann RA, Bell JD, Judd AM. Stimulation by interleukin-6 and inhibition by tumor necrosis factor of cortisol release from bovine adrenal zona fasciculata cells through their receptors. Endocrine 2000; 13: 369-377
4. González-Hernández JA, Ehrhart-Bornstein M, Späth-Schwalbe E, Scherbaum WA, Bornstein SR. Human adrenal cells express tumor necrosis factor-alpha messenger ribonucleic acid: evidence for paracrine control of adrenal function. J Clin Endocrinol Metab 1996; 81: 807-813
5. González-Hernández JA, Bornstein SR, Ehrhart-Bornstein M, Späth-Schwalbe E, Jirikowski G, Scherbaum WA. Interleukin-6 messenger ribonucleic acid expression in human adrenal gland in vivo: new clue to a paracrine or autocrine regulation of adrenal function. J Clin Endocrinol Metab 1994; 79: 1492-1497
6. Hinson JP, Kapas S, Teja R, Vinson GP. Effect of the endothelins on aldosterone secretion by rat zona glomerulosa cells in vitro. J Steroid Biochem Mol Biol 1991; 40: 43743-43749
7. Jirik FR, Podor TJ, Hirano T, Kishimoto T, Loskutoff DJ, Carson DA, Lotz M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 1989; 142: 144-177
8. Hoshi H, MacKeehan WL. Brain- and liver cell-derived factors are required for growth of human endothelial cells in serum-free culture. Proc Natl Acad Sci USA 1984; 81: 6413-6417
9. Judd AM, MacLeod RM. Adrenocorticotropin increases interleukin-6 release from rat adrenal zona glomerulosa cells. Endocrinology 1992; 130: 1245-1254
10. Mazzocchi G, Rossi GP, Rebuffat P, Malendowicz LK, Markowska A, Nussdorfer GG. Endothelin-1 stimulates deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C-and tyrosine kinase-dependent signaling pathways. Endocrinology 1997; 138: 2333-2338
11. 2. Proc Natl Acad Sci USA 2005; 102: 6213-6218
12. Muramami N, Fukata J, Tsukada T, Kobayashi H, Ebisui O, Segawa H, Muro S, Imura H, Nakao K. Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen. Endocrinology 1993; 133: 2574-2578
13. Nagy Z, Radeff J, Stern PH. Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists. Bone Miner Res 2001; 16: 1220-1227
14. Nilsen EM, Johansen F-E, Jahnsen FL, Lundin KEA, Scholz T, Brandtzaeg P, Haraldsen G. Cytokine profiles of cultured microvascular endothelial cells from the human intestine. Gut 1998; 42: 635-642
15. Päth G, Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA. Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis. J Clin Endocrinol Metab 1997; 82: 2343-2349
16. Podor TJ, Jirik FR, Loskutoff DJ, Carson DA, Lotz M. Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Ann NY Acad Sci 1989; 557: 374-385
17. Rosolowsky LJ, Hanke CJ, Campbell WB. Adrenal capillary endothelial cells stimulate aldosterone release through a protein that is distinct from endothelin. Endocrinology 1999; 140: 4411-4418
18. Schobitz B, Holsboer F, Kikkert R, Sutanto W, Kloet ER De. Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats. Endocr Regul 1992; 26: 103-109
19. Turnbull AV, Prehar S, Kennedy AR, Little RA, Hopkins SJ. Interlukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology 2003; 144: 1894-1906
20. Willenberg HS, Päth G, Vögeli TA, Scherbaum WA, Bornstein SR. Role of Interleukin-6 in the stress response in normal and tumorous adrenal cells and during chronic inflammation. Ann NY Acad Sci 2002; 966: 304-314
21. Willenberg HS. Diagnostik und Therapie von Mineralokortikoidexzeßsyndromen. Roman J Endocrinol Metab 2007; 2: 13-23
22. Yudkin JS. Inflammation, obesity, and the metabolic syndrome. Horm Metab Res 2007; 39: 707-709
23. Zhou D, Kusnecov AW, Shurin MR, DePaoli M, Rabin BS. Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 1993; 133: 2523-2530