Compare of molecule characteristics and bioactivity of low-molecular- weight-heparin products in market

Chinese Pharmaceutical Journal

Volumn 42, Issue 6, 2007, Pages 461-465

  Gu, Jian ^a   Yang, Jun ^a   Zhang, Chun Yan ^a   Zhang, Hai Ying ^a   Li, Yu Zhen ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Aminoglucose; Anti II a activity; Anti X a activity; Glycuronic acid; Low molecule weight heparin; Molecular weight; Sulphuric group

Indexed keywords

DALTEPARIN; ENOXAPARIN; LIVARACINE; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG STRUCTURE; MOLECULAR WEIGHT;

EID: 54549094854     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. CAO P, ZHANG L S. Study on anticoagulant effects and antithrombotic effects of low molecule weight heparin (LMWH) [J]. Chin J Hosp Pharm,2001,21(5):289-291.
2. YANG X H, LING P X, WANG F S, et al. Application of heparin in Autoimmune disease[J]. Chin Biochem J,1995,15:281-283.
3. RACINE E. Differentiation of the low-molecular-weight heparins [J]. Pharmacotherapy, 2001, 21: 62-70.
4. WANG F S, LING P X. Study on Biochemical Pharmaceutics [M]. Beijing: People health press,1997:110-225.
5. XIE J Q, WANG F S, CUI H F, et al. Optimization on the operation procedure of chondroitin sulfate content determination[J]. Chin J Biochem Pharm, 2000, 21: 243-244.
6. BITTER T, MUIR H M. Amodified Uronic acid carbazole reaction [J]. Anal Biochem,1962,4:330-334.
7. TERHO T T, HARTIAL A K. Method for determination of the sulfate content of glycosaminoglycans[J]. Anal Biochem, 1971, 41:471-476.
8. British Pharmacopoeia(2003) [S]. 2003:920.
9. FAREED J, JESKE W, HOPPENSTEADT D,et al. Are the available low-molecular weighe heparin preparations the same[J]. Semin Thromb Hemost,1996,22 (suppl 1): 77-91.
10. LOU Z, ZHANG T M. Relationship between molecular weight and antithrombus effectof low-molecular-weight heparins from low-anticoagulatedheparins[J]. Chin Pharm J, 1991,26:552-554.
11. SHI F, JI S L, CHI Y Q, et al. Preparation of LMWH and the relationship between its structure and bioactivity[J]. Chin J Biochem Pharm, 2003, 24: 101-104.
12. GAO H, ZHANG T M, ZHANG Z G. Physico-chemical property and bioactivity of heparin from different source[J]. Acta Acad Med Shandong,1987,25(2):41- 46.