Leptin in acute coronary syndromes: Has the time come for its use in risk stratification?

International Journal of Cardiology

Volumn 130, Issue 2, 2008, Pages 264-265

  Amasyali, Basri ^a   Kose, Sedat ^a   Kursaklioglu, Hurkan ^a   Kilic, Ayhan ^a   Isik, Ersoy ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Acute coronary syndromes; Leptin; Thrombosis

Indexed keywords

BIOLOGICAL MARKER; LEPTIN; REACTIVE OXYGEN METABOLITE;

ACUTE CORONARY SYNDROME; ARTERY THROMBOSIS; ARTICLE; BODY WEIGHT; ENERGY EXPENDITURE; ENERGY METABOLISM; FOOD INTAKE; HUMAN; ISCHEMIC HEART DISEASE; NERVE CONDUCTION; PATHOGENESIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SYMPATHETIC NERVE; THROMBOCYTE AGGREGATION;

ACUTE CORONARY SYNDROME; BIOLOGICAL MARKERS; HUMANS; LEPTIN; OBESITY; RISK FACTORS; TIME FACTORS;

EID: 54549092605     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2007.07.007     Document Type: Article

References (15)

1. Dubey L., Zeng H., Hashmi S., Hongjie W., and Tao H. Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina. Int J Cardiol 126 (2008) 183-189
2. Zimmet P., Hodge A., Nicolson M., et al. Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross-sectional study. Br Med J 313 (1996) 965-969
3. Konstantinides S., Schafer K., Koschnick S., and Loskutoff D.J. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108 (2001) 1533-1540
4. Soderberg S., Ahren B., Jansson J.H., et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 246 (1999) 409-418
5. Soderberg S., Olsson T., Eliasson M., Johnson O., and Ahren B. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Intern Med 245 (1999) 533-543
6. Wolk R., Berger P., Lennon R.J., Brilakis E.S., Johnson B.D., and Somers V.K. Plasma leptin and prognosis in patients with established coronary atherosclerosis. J Am Coll Cardiol 44 (2004) 1819-1824
7. Bouloumie A., Marumo T., Lafontan M., and Busse R. Leptin induces oxidative stress in human endothelial cells. FASEB J 13 (1999) 1231-1238
8. Doehner W., Rauchhaus M., Godsland I.F., et al. Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha. Int J Cardiol 83 (2002) 73-81
9. Napoleone E., Di Santo A., Amore C., et al. Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk?. J Thromb Haemost 5 (2007) 1462-1468
10. De Mitrio V., De Pergola G., Vettor R., et al. Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women. Metabolism 48 (1999) 960-964
11. Amasyali B., Aytemir K., Kose S., et al. Admission plasma leptin level strongly correlates with the success of thrombolytic therapy in patients with acute myocardial infarction. Angiology 57 (2006-2007) 671-680
12. Sinha M.K., Ohannesian J.P., Heiman M.L., et al. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97 (1996) 1344-1347
13. Biasucci L.M., Liuzzo G., Angiolillo D.J., Sperti G., and Maseri A. Inflammation and acute coronary syndromes. Herz 25 (2000) 108-112
14. Janik J.E., Curti B.D., Considine R.V., et al. Interleukin 1 alpha increases serum leptin concentrations in humans. J Clin Endocrinol Metab 82 (1997) 3084-3086
15. Sarraf P., Frederich R.C., Turner E.M., et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 185 (1997) 171-175