Role of Nuclear Scintigraphy in the Characterization and Management of the Salivary Component of Sjögren's Syndrome

Rheumatic Disease Clinics of North America

Volumn 34, Issue 4, 2008, Pages 973-986

  Vivino, Frederick B ^a   Hermann, George A ^b  

^a PENN PRESBYTERIAN MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Salivary radionuclide scintigraphy; Sj gren's syndrome

Indexed keywords

ASCORBIC ACID; CARBECHOL; CHOLINERGIC RECEPTOR STIMULATING AGENT; CITRIC ACID; MOLYBDENUM 99; PERTECHNETIC ACID TC 99M; PILOCARPINE; TARTARIC ACID; TECHNETIUM 99M; TRACER; UNCLASSIFIED DRUG;

CLINICAL PROTOCOL; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DRY EYE; HUMAN; LABORATORY DIAGNOSIS; LEMON JUICE; PAROTID GLAND; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; REVIEW; SALIVARY GLAND SCINTISCANNING; SALIVATION; SCINTILLATION CAMERA; SJOEGREN SYNDROME; SUBMANDIBULAR GLAND; WHOLE BODY RADIATION; XEROSTOMIA;

FEMALE; HUMANS; MIDDLE AGED; PAROTID GLAND; SJOGREN'S SYNDROME; SUBMANDIBULAR GLAND;

EID: 54549083236     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rdc.2008.08.011     Document Type: Review

References (64)

1. Vitali C., Bombardieri S., Jonsson R., et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61 6 (2002) 554-558
2. Bowman S.J., Pillemer S., Jonsson R., et al. Revisiting Sjögren's syndrome in the new millennium: perspectives on assessment and outcome measures. Report of a workshop held on 23 March 2000 at Oxford, UK. Rheumatology 40 10 (2001) 1180-1188
3. Pillemer S.R., Smith J., Fox P.C., et al. Outcome measures for Sjögren's syndrome, April 10-11, 2003, Bethesda, Maryland, USA. J Rheumatol 31 1 (2004) 143-149
4. Mandl T., Jacobsson L., Lilja B., et al. Disturbances of autonomic nervous function in primary Sjögren's syndrome. Scand J Rheumatol 26 5 (1997) 410-416
5. Wright R.A., Grant I.A., and Low P.A. Autonomic neuropathy associated with sicca complex. J Auton Nerv Syst 75 1 (1999) 70-76
6. Vivino F.B., Al-Hashimi I., Khan Z., et al. Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren's syndrome. Arch Intern Med 159 2 (1999) 174-181
7. Cooper R.A., Cowan R.A., Owens S.E., et al. Does salivary gland scintigraphy predict response to pilocarpine in patients with postradiotherapy xerostomia?. Eur J Nucl Med 26 3 (1999) 220-225
8. Rosas J., Ramos-Casals M., Ena J., et al. Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjögren's syndrome. Correlation with clinical, immunological, and histological features. Rheumatology (Oxford) 41 6 (2002) 670-675
9. Li J., Ha Y.M., Ku N.Y., et al. Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome. Lab Invest 84 11 (2004) 1430-1438
10. Nakayamada S., Saito K., Umehara H., et al. Efficacy and safety of mizoribine for the treatment of Sjögren's syndrome: a multicenter open-label clinical trial. Mod Rheumatol 17 6 (2007) 464-469
11. Jadvar H., Bonyadlou S., Iagaru A., et al. FDG PET-CT demonstration of Sjögren's sialoadenitis. Clin Nucl Med 30 10 (2005) 698-699
12. Basu S., Houseni M., and Alavi A. Significance of incidental flourodeoxyglucose uptake in the parotid glands and its impact on patient management. Nucl Med Commun 29 4 (2008) 367-373
13. McAfee J.G., Fueger C.F., Stern H.S., et al. Tc-99m pertechnetate for brain scanning. J Nucl Med 5 11 (1964) 811-827
14. Ahiner B.H., and Lind M.G. The capacity of irradiated rabbit submandibular glands to concentrate 99mTcO4 pertechnetate. Eur Arch Otorhinolaryngol 249 8 (1993) 462-465
15. Taplin G.V., Dore E.K., and Johnson D.E. Suspensions of radioalbumin aggregate for photoscanning the liver, spleen, lungs, and other organs. UCLA-519. UCLA Rep 86 11 (1963) 1-39
16. Harper P.V., Beck R., Charleston D., et al. Optimization of a scanning method using 99mTc. Nucleonics 22 1 (1964) 50-54
17. Bömer W., Grünberg H., and Moll E. Die szintigraphische Darstellung der Kopfspeicheldrusen mit Technetium-99m. Med Welt 42 43 (1965) 2378-2390
18. Schall G.L., Anderson L.G., Wolf R.O., et al. Xerostomia in Sjögren's syndrome. JAMA 216 13 (1971) 2109-2116
19. Schall G.L., Larson S.M., Anderson L.G., et al. Quantification of parotid gland uptake of pertechnetate using a gamma scintillation camera and a region-of-interest system. Am J Roentgenol Radium Ther Nucl Med 115 4 (1972) 689-697
20. Stephen K.W., Robertson J.W., and Harden R.M. Quantitative aspects of pertechnetate concentration in human parotid and submandibular glands. Br J Radiol 49 588 (1976) 1028-1032
21. Häusler R.J., Ritschard J., N'Guyen V.T., et al. Differential diagnosis of xerstomia by quantitative salivary gland scintigraphy. Ann Otol Rhinol Laryngol 86 3 Pt 1 (1977) 333-341
22. Arrago J.P., Rain J.D., Brocheriou C., et al. Scintigraphy of the salivary glands in Sjögren's syndrome. J Clin Pathol 40 12 (1987) 1463-1467
23. Wang S., Zou Z., and Zhu J. Sequential quantitative scintigraphy of parotid glands with chronic inflammatory diseases. J Oral Maxillofac Surg 50 5 (1992) 456-465
24. Bohuslavizki K.H., Brenner W., Wolf H., et al. Value of quantitative salivary gland scintigraphy in the early stage of Sjögren's syndrome. Nucl Med Commun 16 11 (1995) 917-922
25. Umehara I., Yamada I., Murata Y., et al. Quantitative evaluation of salivary gland scintigraphy in Sjögren's syndrome. J Nucl Med 40 1 (1999) 64-69
26. Daniels T.E., Powell M.R., Sylvester R.A., et al. An evaluation of salivary scintigraphy in Sjögren's syndrome. Arthritis Rheum 22 8 (1979) 809-814
27. Delpassand E.S., Zare F., Broussard W., et al. Functional ratios of normal salivary glands using dual detector gamma camera and geometric means. Clin Nucl Med 22 3 (1997) 200 [abstract]
28. van Acker F., Flamen P., Lambin P., et al. The utility of SPECT in determining the relationship between radiation dose and salivary gland dysfunction after radiotherapy. Nucl Med Commun 22 2 (2001) 225-231
29. Hermann G.A., Vivino F.B., Shnier D., et al. Variability of quantitative salivary indices in normal subjects. J Nucl Med 39 7 (1998) 1260-1263
30. 99mTc. Clin Sci 32 1 (1967) 49-55
31. Malpani B.L., Samuel A.M., and Ray S. Differential kinetics of parotid and submandibular gland function as demonstrated by scintigraphic means and its possible implications. Nucl Med Commun 16 8 (1995) 706-709
32. Aung W., Murata Y., Ishida R., et al. Study of quantitative oral radioactivity in salivary gland scintigraphy and determination of the clinical stage of Sjögren's syndrome. J Nucl Med 42 1 (2001) 38-43
33. Han R., Zagar I., Mitrovic S., et al. Salivary excretory index-quantification of the ascorbic acid response in dynamic radionuclide sialography. Med Pregl 46 Suppl 1 (1993) 54-55
34. Parret J., and Peyrin J.O. Radioisotopic investigations in salivary pathology. Clin Nucl Med 4 6 (1979) 250-261
35. 99mTc-scintigraphy: a grading scale and correlation with major salivary gland flow rates. J Oral Pathol Med 21 2 (1992) 70-74
36. Sugihara T., and Yoshimura Y. Scintigraphic evaluation of the salivary glands in patients with Sjögren's syndrome. Int J Oral Maxillofac Surg 17 2 (1988) 71-75
37. De Rossi G., and Focacci C. A computer-assisted method for semiquantitative assessment of salivary gland diseases. Eur J Nucl Med 5 6 (1980) 499-503
38. Valdés-Olmos R.A., Keus R.B., Takes R.P., et al. Scintigraphic assessment of salivary function and excretion response in radiation-induced injury of the major salivary glands. Cancer 73 12 (1994) 2886-2893
39. Demangeat R., Didon-Poncelet A., Cherfan J., et al. Stimulated salivary pertechnetate clearance revisited: correlation with dynamic scintigraphic indices in sicca syndrome. Clin Nucl Med 25 11 (2000) 888-894
40. Chisin R., Markitziu A., Hoffer S., et al. The clinical value of quantitative dynamic scintigraphy in salivary gland disorders. Int J Rad Appl Instrum B 15 3 (1988) 313-317
41. De Jager J.P., Choy D., and Fleming A. Salivary scanning in rheumatoid arthritis with sicca syndrome. Ann Rheum Dis 43 4 (1984) 610-612
42. Hakansson U., Jacobsson L., Manthorpe R., et al. Salivary gland scintigraphy in subjects with and without symptoms of dry mouth and/or eyes, and in patients with primary Sjögren's syndrome. Scand J Rheumatol 23 6 (1994) 326-333
43. Kosuda S., Suzuki K., Kawakami R., et al. Reassessment of usefulness of salivary scintigraphy in diagnosis of Sjögren's syndrome. Kaku Igaku 30 2 (1993) 161-170
44. Mita S., Kohno M., Matsuoka Y., et al. Diagnostic availability of RI-sialography in Sjögren's syndrome. Ryumachi 21 4 (1981) 305-316
45. Markusse H.M., Pillay M., and Breedveld F.C. The diagnostic value of salivary gland scintigraphy in patients suspected of primary Sjögren's syndrome. Br J Rheumatol 32 3 (1993) 231-235
46. Henriksen A.M., and Nossent H.C. Quantitative salivary gland scintigraphy can distinguish patients with primary Sjögren's syndrome during the evaluation of sicca symptoms. Clin Rheumatol 26 11 (2007) 1837-1841
47. Roescher N., and Illei G.G. Can quantified salivary gland scintigraphy results aid diagnosis of patients with sicca symptoms?. Nat Clin Pract Rheumatol 4 4 (2008) 178-179
48. Scott J., Cawood J.I., Grime J.S., et al. Histological evaluation of quantitative scintigraphy of the salivary glands in a primate model. Int J Oral Surg 13 1 (1984) 45-52
49. Mauch E., Volk C., Kratzsch G., et al. Neurological and neuropsychiatric dysfunction in primary Sjögren's syndrome. Acta Neurol Scand 89 1 (1994) 31-35
50. Mori K., Iijima M., Koiki H., et al. The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain 128 11 (2005) 2518-2534
51. Hermann G.A., Vivino F.B., and Goin J.E. Scintigraphic features of chronic sialadenitis and Sjögren's syndrome: a comparison. Nucl Med Commun 20 12 (1999) 1123-1132
52. Nishiyama S., Miyawaki S., and Yoshinaga Y. A study to standardize quantitative evaluation of parotid gland scintigraphy in patients with Sjögren's syndrome. J Rheumatol 33 12 (2006) 2470-2474
53. Coll J., Porta M., Rubiés-Prat J., et al. Sjögren's syndrome: a stepwise approach to the use of diagnostic tests. Ann Rheum Dis 51 5 (1992) 607-610
54. Martinez-Lázaro R., Cortés-Blanco A., and Velilla J. A pilot study of the salivary scintigraphy diagnostic performance in a Spanish population with with Sjögren's syndrome diagnosed by the European criteria. Ann Rheum Dis 60 3 (2001) 302-303
55. Fossaluzza V., De Vita S., and Geatti O. Sequential salivary scintigraphy in Sjögren's syndrome: proposal for a new method of evaluation. Clin Exp Rheumatol 8 5 (1990) 469-474
56. Blue P.W., and Jackson J.H. Stimulated salivary clearance of technetium-99m pertechnetate. J Nucl Med 26 3 (1985) 308-311
57. Malpani B.L., Jaiswar R.K., and Samuel A.M. Variability of quantitative scintigraphic salivary indices in healthy subjects. J Nucl Med 40 12 (1999) 2129-2130
58. Malpani B.L., Jaiswar R.K., and Samuel A.M. Noninvasive scintigraphic method to quantify unstimulated secretions from individual salivary glands. Auris Nasus Larynx 26 4 (1999) 453-456
59. Fox P.C., Busch K.A., and Baum B.J. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc 115 4 (1987) 581-584
60. Hay E.M., Thomas E., Pal B., et al. Weak association between subjective symptoms of and objective testing for dry eyes and dry mouth: results from a population-based study. Ann Rheum Dis 57 1 (1998) 20-24
61. Pijpe J., Kalk W.W., Bootsma H., et al. Progression of salivary gland dysfunction in patients with Sjögren's syndrome. Ann Rheum Dis 66 1 (2007) 107-112
62. Dugonjić S., Ajdinović B., Stefanović D., et al. Diagnostic validity of dynamic salivary gland scintigraphy with ascorbic acid stimulation in patients with Sjögren's syndrome: comparison with unstimulated whole sialometry. Vojnosanit Pregl 65 1 (2008) 41-46
63. Booker J., Howarth D., Taylor L., et al. Appropriate utilization of semiquantitative analysis in salivary scintigraphy. Nucl Med Commun 25 12 (2004) 1203-1210
64. Adams B.K., Al Attia H.M., and Parkar S. Salivary gland scintigraphy in Sjögren's syndrome: are quantitative indices the answer?. Nucl Med Commun 24 9 (2003) 1011-1016