Binding of recombinant but not endogenous prion protein to DNA Causes DNA internalization and expression in mammalian cells

Journal of Biological Chemistry

Volumn 283, Issue 37, 2008, Pages 25446-25454

  Yin, Shaoman ^a   Fan, Xingjun ^a   Yu, Shuiliang ^a   Li, Chaoyang ^a   Sy, Man Sun ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CALCIUM; CELL MEMBRANES; DNA; GENE EXPRESSION; GENES; MAMMALS; NUCLEIC ACIDS;

CELL SURFACES; CELLULAR PRION PROTEINS; DNA COMPLEXES; MAMMALIAN CELLS; N TERMINUSES; NORMAL FUNCTIONS; PATHOGENIC MECHANISMS; PRION DISEASES; PRION PROTEINS;

ORGANIC ACIDS;

CALCIUM ION; DNA; OCTAPEPTIDE; PRION PROTEIN; PROTEINASE K; RECOMBINANT PROTEIN; CALCIUM;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; INTERNALIZATION; MUTATIONAL ANALYSIS; NONHUMAN; PINOCYTOSIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN TRANSPORT; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; GENE EXPRESSION REGULATION; HAMSTER; KINETICS; METABOLISM; PRION;

MAMMALIA;

AMINO ACID MOTIFS; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; DNA; ENDOPEPTIDASE K; GENE EXPRESSION REGULATION; HUMANS; KINETICS; PINOCYTOSIS; PRIONS; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 54449094301     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800814200     Document Type: Article

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