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Volumn 3, Issue 8, 2008, Pages 1173-1177

"Superbugs bunny" outsmarts our immune defense

Author keywords

Antibiotics; Carotenoids; Cholesterol; Dehydrosqualene synthase; Staphylococcus aureus; Staphyloxanthin

Indexed keywords

CHOLESTEROL; STAPHYLOXANTHIN; VIRULENCE FACTOR; XANTHOPHYLL;

EID: 54449089765     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800171     Document Type: Short Survey
Times cited : (4)

References (50)
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    • All work in reference [10] was carried out with racemic compounds. However, the authors have meanwhile tested the pure R and S enantiomers of 12 in the enzyme and in cells. The S form was far more active in both cases: E. Oldfield, personal communication, 2008.
    • All work in reference [10] was carried out with racemic compounds. However, the authors have meanwhile tested the pure R and S enantiomers of 12 in the enzyme and in cells. The S form was far more active in both cases: E. Oldfield, personal communication, 2008.
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    • The racemate of 12 was used in crystallization. As it is difficult to unambiguously discriminate between phosphorous and sulfur in X-ray crystallography, it remains uncertain whether the bound form was the less active R or indeed the more active S enantiomer of 12.
    • The racemate of 12 was used in crystallization. As it is difficult to unambiguously discriminate between phosphorous and sulfur in X-ray crystallography, it remains uncertain whether the bound form was the less active R or indeed the more active S enantiomer of 12.
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    • The synthesis of (S)-(-)-3-phenoxy-α- phosphonobenzenebutanesulfonic acid, tripotassium salt (12) was carried out in 88% ee by asymmetric alkylation: D. R. Magnin, S. A. Biller, J. K. Dickson, Jr., R. M. Lawrence, R. B. Sulsky (E. R. Squibb and Sons, Inc., USA), EP595635, 1994, [Chem. Abstr. 1994, 121, 157872].
    • The synthesis of (S)-(-)-3-phenoxy-α- phosphonobenzenebutanesulfonic acid, tripotassium salt (12) was carried out in 88% ee by asymmetric alkylation: D. R. Magnin, S. A. Biller, J. K. Dickson, Jr., R. M. Lawrence, R. B. Sulsky (E. R. Squibb and Sons, Inc., USA), EP595635, 1994, [Chem. Abstr. 1994, 121, 157872].
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    • See reference [21a]: Healthy volunteers received a daily oral dose of 10 mg for 2 weeks, or a daily oral dose of 25, 50, 100, or 200 mg for 4 weeks.
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    • In October 2007, the FDA released draft guidance which considered non-inferiority trials unacceptable for self-resolving respiratory tract infections such as acute bacterial sinusitis, exacerbation of chronic bronchitis, and otitis media; an extension to community acquired pneumonia (CAP) is under discussion.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.