Phase I trial of intrathecal liposomal cytarabine in children with neoplastic meningitis

Journal of Clinical Oncology

Volumn 22, Issue 19, 2004, Pages 3916-3921

  Bomgaars, L ^a   Geyer, J R ^a   Franklin, J ^a   Dahl, G ^a   Park, J ^a   Winick, N J ^a   Klenke, R ^a   Berg, S L ^a   Blaney, S M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DEXAMETHASONE; ANTINEOPLASTIC ANTIMETABOLITE; LIPOSOME;

ARACHNOIDITIS; ARTICLE; BACKACHE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; FEVER; HEADACHE; HUMAN; LUMBAR PUNCTURE; MENINGIOMA; NAUSEA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; VOMITING; ADOLESCENT; ADULT; DRUG DELIVERY SYSTEM; FEMALE; GLIOMA; INDWELLING CATHETER; INTRASPINAL DRUG ADMINISTRATION; LEUKEMIA; MALE; MAXIMUM TOLERATED DOSE; MEDULLOBLASTOMA; METABOLISM; PRESCHOOL CHILD; PUNCTURE;

ADOLESCENT; ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; CATHETERS, INDWELLING; CHILD; CHILD, PRESCHOOL; CYTARABINE; DRUG DELIVERY SYSTEMS; FEMALE; GLIOMA; HUMANS; INJECTIONS, SPINAL; LEUKEMIA; LIPOSOMES; MALE; MAXIMUM TOLERATED DOSE; MEDULLOBLASTOMA; MENINGEAL NEOPLASMS; SPINAL PUNCTURE;

EID: 5444268197     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2004.01.046     Document Type: Article

References (10)

1. Murry DJ, Blaney SM: Clinical pharmacology of encapsulated sustained-release cytarabine. Ann Pharmacother 34:1173-1178, 2000
2. Chamberlain MC, Kormanik P, Howell SB, et al: Pharmacokinetics of intralumbar DTC-101 for the treatment of leptomeningeal metastases. Arch Neurol 52:912-917, 1995
3. Kim S, Chatelut E, Kim JC, et al: Extended CSF cytarabine exposure following intrathecal administration of DTC 101. J Clin Oncol 11:2186-2193, 1993
4. Blaney S, Poplack D, Godwin K, et al: effect of body position on ventricular CSF methotrexate concentration following intralumbar administration. J Clin Oncol 13:177-179, 1995
5. National Cancer Institute: Guidelines for Reporting of Adverse Drug Reactions. Bethesda, MD, Divisions of Cancer Treatment, National Cancer Institute. 1988
6. Chamberlain MC, Khatibi S, Kim JC, et al: Treatment of leptomeningeal metastasis with intraventricular administration of depot cytarabine (DTC 101). A phase I study. Arch Neurol 50:261-264, 1993
7. Glantz MJ, Jaeckle KA, Chamberlain MC, et al: A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 5:3394-3402, 1999
8. Glantz MJ, LaFollette S, Jaeckle KA, et al: Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis. J Clin Oncol 17:3110-3116, 1999
9. Jaeckle KA, Batchelor T, O'Day SJ, et al: An open label trial of sustained-release cytarabine (DepoCyt) for the intrathecal treatment of solid tumor neoplastic meningitis. J Neurooncol 57:231-239, 2002
10. Zimm S, Collins JM. Miser J, et al: Cytosine arabinoside cerebrospinal fluid kinetics. Clin Pharmacol Ther 35:826-830, 1984