Using a nonlinear mixed effects model to characterize cholinesterase activity in rats exposed to Aldicarb

Journal of Agricultural, Biological, and Environmental Statistics

Volumn 8, Issue 4, 2003, Pages 420-437

  Clayton, C A ^a   Starr, T B ^b   Sielken Jr , R L ^c   Williams, R L ^a   Pontal, P G ^d   Tobia, A J ^e  

^a RTI INTERNATIONAL   (United States)

^b TBS Associates   (United States)

^c Sielken & Associates Inc   (United States)

^d CEHTRA   (France)

^e BAYER CROPSCIENCE   (United States)

Author keywords

Carbamate pesticides; Monte Carlo simulation; Repeated measurements; Sensitivity analysis

Indexed keywords

ENZYME ACTIVITY;

ANIMALIA;

EID: 5444267903     PISSN: 10857117     EISSN: None     Source Type: Journal    
DOI: 10.1198/1085711032651     Document Type: Article

References (8)

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2. Ellman, G.L., Courney, K. D., Andres, V. Jr., and Featherstone, R. M. (1961), "A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity," Biometrics, 20, 482-491.
3. Lindstrom, M. J., and Bates, D. M. (1990), "Nonlinear Mixed Effects Models for Repeated-Measures Data," Biometrics, 46, 673-687.
4. Littell, R. C., Milliken, G. A., Stroup, W. W., and Wolfinger, R. D. (1996), SAS System for Mixed Models, Cary, NC: SAS Institute, Inc., Appendix 3.
5. Morrell, C. H., Pearson, J. D., Carter, B., and Brant, L. J. (1995), "Estimating Unknown Transition Times Using a Piecewise Nonlinear Mixed-Effects Model in Men with Prostate Cancer," Journal of the American Statistical Association, 90, 45-53.
6. O'Brien R. D. (1967), Insecticides: Action and Metabolism, New York: Academic Press.
7. Pinheiro, J. C., and Bates, D. M. (2000), Mixed-Effect Models in S and S-PLUS, New York: Springer-Verlag.
8. Tyl, R. W., and Anderson, S. A. (2000), "The Toxicokinetics of Peripheral Cholinesterase Inhibition from Orally Administered Aldicarb in Adult Male CD® Rats," Research Triangle Institute Final Report 65C-07532, Research Triangle Institute, Research Triangle Park,