Identification by phage display selection of a short peptide able to inhibit only the strand transfer reaction catalyzed by human immunodeficiency virus type 1 integrase

Biochemistry

Volumn 43, Issue 41, 2004, Pages 13097-13105

  Desjobert, Cecile ^a   De Soultrait, Vaea Richard ^b   Faure, Aurelie ^b   Parissi, Vincent ^b   Litvak, Simon ^b   Tarrago Litvak, Laura ^b   Fournier, Michel ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL DRUG DESIGN; BINDING AGENTS; CELL GENOME; HUMAN IMMUNODEFICIENCY VIRUS (HIV);

CATALYSIS; DNA; DRUG DOSAGE; ENZYME INHIBITION; GENES;

VIRUSES;

HISTIDYLLEUCYLGLUTAMYLHISTIDYLLEUCYLLEUCYLPHENYLALANINE; INTEGRASE; PEPTIDE; PHENYLALANYLHISTIDYLASPARAGINYLHISTIDYLGLYCYLLYSYLGLUTAMINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DNA STRAND; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; MOLECULAR CLONING; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

BACTERIOPHAGE M13; BINDING, COMPETITIVE; CATALYSIS; CATALYTIC DOMAIN; DIMERIZATION; DNA-BINDING PROTEINS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC; VIRAL FUSION PROTEINS; VIRUS INTEGRATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 5444264830     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049385e     Document Type: Article

References (43)

1. Coffin, J. M., Hughes, S. H., and Varmus, H. E. (1997) Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. Bushman, F. (2002) Lateral DNA transfer, pp 169-235, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. Asante-Appiah, E., and Skalka, A. M. (1999) HIV-1 integrase: structural organization, conformational changes, and catalysis, Adv. Virus Res. 52, 351-369.
4. Zheng, R., Jenkins, T. M., and Craigie, R. (1996) Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity, Proc. Natl. Acad. Sci. U.S.A. 93, 13659-13664.
5. Heuer, T. S., and Brown, P. O. (1998) Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type I integrase-DNA complex, Biochemistry 37, 6667-6678.
6. Eijkelenboom, A. P., Lutzke, R. A., Boelens, R., Plasterk, R. H., Kaptein, R., and Hard, K. (1995) The DNA-binding domain of HIV-1 integrase has an SH3-like fold, Nat. Struct. Biol. 2, 807-810.
7. Lutzke, R. A., and Plasterk, R. H. (1998) Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding, J. Virol. 72, 4841-4848.
8. Goldgur, Y., Craigie, R., Cohen, G. H., Fujiwara, T., Yoshinaga, T., Fujishita, T., Sugimoto, H., Endo, T., Murai, H., and Davies, D. R. (1999) Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design, Proc. Natl. Acad. Sci. U.S.A. 96, 13040-13043.
9. Hazuda, D. J., Felock, P., Witmer, M., Wolfe, A., Stillmock, K., Grobler, J. A., Espeseth, A., Gabryelski, L., Schleif, W., Blau, C., and Miller, M. D. (2000) Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells, Science 287, 646-650.
10. Espeseth, A. S., Felock, P., et al. (2000) HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase, Proc. Natl. Acad. Sci. U.S.A. 97, 11244-9.
11. Grobler, J. A., Stillmock, K., Hu, B., Witmer, M., Felock, P., Espeseth, A. S., Wolfe, A., Egbertson, M., Bourgeois, M., Melamed, J., Wai, J. S., Young, S., Vacca, J., and Hazuda, D. J. (2002) Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes, Proc. Natl. Acad. Sci. U.S.A. 99, 6661-6
12. Zouhiri, F., Mouscadet, J. F., Mekouar, K., Desmaele, D., Savoure, D., Leh, H., Subra, F., Le Bret, M., Auclair, C., and d'Angelo, J. (2000) Structure - activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture, J. Med. Chem. 43, 1533-1540.
13. Jing, N. (2000) Developing G-quartet oligonucleotides as novel anti-HIV agents: focus on anti-HIV drug design, Expert Opin. Invest. Drugs 9, 1777-1785.
14. Neamati, N., Mazumder, A., Zhao, H., Sunder, S., Burke, T. R., Jr., Schultz, R. J., and Pommier, Y. (1997) Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors, Antimicrob. Agents Chemother. 41, 385-393.
15. Pluymers, W., Neamati, N., Pannecouque, C., Fikkert, V., Marchand, C., Burke, T. R., Jr., Pommier, Y., Schols, D., De Clercq, E., Debyser, Z., and Witvrouw, M. (2000) Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters, Mol. Pharmacol. 58, 641-648.
16. Pommier, Y., Marchand, C., and Neamati, N. (2000) Retroviral integrase inhibitors year 2000: update and perspectives, Antiviral Res. 47, 139-148.
17. Young, S. D. (2001) Inhibition of HIV-1 integrase by small molecules: the potential for a new class of AIDS chemotherapeutics, Curr. Opin. Drug Discovery Dev. 4, 402-410.
18. Tarrago-Litvak, L., Andreola, M. L., Fournier, M., Nevinsky, G. A., Parissi, V., de Soultrait, V. R., and Litvak, S. (2002) Inhibitors of HIV-1 reverse transcriptase and integrase: classical and emerging therapeutical approaches, Curr. Pharm. Des. 8, 595-614.
19. Pannecouque, C., Pluymers, W., Van Maele, B., Tetz, V., Cherepanov, P., De Clercq, E., Witvrouw, M., and Debyser, Z. (2002) New class of HIV integrase inhibitors that block viral replication in cell culture, Curr. Biol. 12, 1169-77.
20. Pluymers, W., Pais, G., Van Maele, B., Pannecouque, C., Fikkert, V., Burke, T. R., Jr., De Clercq, E., Witvrouw, M., Neamati, N., and Debyser, Z. (2002) Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives, Antimicrob. Agents Chemother. 46, 3292-7.
21. Fikkert, V., Van Maele, B., Vercammen, J., Hantson, A., Van Remoortel, B., Michiels, M., Gurnari, C., Pannecouque, C., De Maeyer, M., Engelborghs, Y., De Clercq, E., Debyser, Z., and Witvrouw, M. (2003) Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations, J. Virol. 77 (21), 11459-70.
22. de Soultrait, V. R., Desjobert, C., and Tarrago-Litvak, L. (2003) Peptides as new inhibitors of HIV-1 reverse transcriptase and integrase, Curr. Med. Chem. 10 (18), 1765-78.
23. Puras Lutzke, R. A., Eppens, N. A., Weber, P. A., Houghten, R. A., and Plasterk, R. H. (1995) Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library, Proc. Natl. Acad. Sci. U.S.A. 92, 11456-11460.
24. de Soultrait, V. R., Caumont, A., Durrens, P., Calmels, C., Parissi, V., Recordon, P., Bon, E., Desjobert, C., Tarrago-Litvak, L., and Fournier, M. (2002) HIV-1 integrase interacts with yeast microtubule-associated proteins, Biochim. Biophys. Acta 1575, 40-48.
25. de Soultrait, V. R., Caumont, A., Parissi, V., Morellet, N., Ventura, M., Lenoir, C., Litvak, S., Fournier, M., and Roques, B. (2002) A Novel Short Peptide is a Specific Inhibitor of the Human Immunodeficiency Virus Type 1 Integrase, J. Mol. Biol. 318, 45-58.
26. Ferrer, M., and Harrison, S. C. (1999) Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries, J. Virol. 73, 5795-5802.
27. Li, M. (2000) Applications of display technology in protein analysis, Nat. Biotechnol. 18, 1251-1256.
28. Caumont, A., Jamieson, G., de Soultrait, V. R., Parissi, V., Fournier, M., Zakharova, O. D., Bayandin, R., Litvak, S., Tarrago-Litvak, L., and Nevinsky, G. A. (1999) High affinity interaction of HIV-1 integrase with specific and non-specific single-stranded short oligonucleotides, FEBS Lett. 455, 154-158.
29. Parissi, V., Calmels, C., De Soultrait, V. R., Caumont, A., Fournier, M., Chaignepain, S., and Litvak, S. (2001) Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60, J. Virol. 75, 11344-11353.
30. Leh, H., Brodin, P., Bischerour, J., Deprez, E., Tauc, P., Brochon, J. C., LeCam, E., Coulaud, D., Auclair, C., and Mouscadet, J. F. (2000) Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase, Biochemistry 39, 9285-9294.
31. Chow, S. A. (1997) In vitro assays for activities of retroviral integrase, Methods 12, 306-317.
32. Adey, N. B., Mataragnon, A. H., Rider, J. E., Carter, J. M., and Kay, B. K. (1995) Characterization of phage that bind plastic from phage-displayed random peptide libraries, Gene 156, 27-31.
33. Dufour, E., El Dirani-Diab, R., Boulme, F., Fournier, M., Nevinsky, G., Tarrago-Litvak, L., Litvak, S., and Andreola, M. L. (1998) p66/p51 and p51/p51 recombinant forms of reverse transcriptase from human immunodeficiency virus type 1-interactions with primer tRNA(Lys3), initiation of cDNA synthesis, and effect of inhibitors, Eur. J. Biochem. 251, 487-495.
34. Deprez, E., Tauc, P., Leh, H., Mouscadet, J. F., Auclair, C., and Brochon, J. C. (2000) Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy, Biochemists 39, 9275-9284.
35. Katzman, M., and Katz, R. A. (1999) Substrate recognition by retroviral integrases, Adv. Virus Res. 52, 371-95 (review).
36. Marchand, C., Zhang, X., Pais, G. C., Cowansage, K., Neamati, N., Burke, T. R., Jr., and Pommier, Y. (2002) Structural determinants for HIV-1 integrase inhibition by beta-diketo acids, J. Biol. Chem. 277, 12596-12603.
37. Calmels, C., de Soultrait, V. R., Caumont, A., Desjobert, C., Faure, A., Fournier, M., Tarrago-Litvak, L., and Parissi V. (2004). Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase, Nucleic Acids Res. 32, 1527-38.
38. Bugreev, D. V., Baranova, S., Zakharova, O. D., Parissi, V., Desjobert, C., Sottofatori, E., Balbi, A., Litvak, S., Tarrago-Litvak, L., and Nevinsky, G. A. (2003). Dynamic, thermodynamic and kinetic basis for recognition and transformation of DNA by Human Immunodeficiency Virus type 1 Integrase, Biochemistry 42 (30), 9235-47.
39. Dirac, A. M., and Kjems, J. (2001) Mapping DNA-binding sites of HIV-1 integrase by protein footprinting, Eur. J. Biochem. 268, 743-751.
40. Chen, J. C., Krucinski, J., Miercke, L. J., Finer-Moore, J. S., Tang, A. H., Leavitt, A. D., and Stroud, R. M. (2000) Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding, Proc. Natl. Acad. Sci. U.S.A. 97, 8233-8238.
41. Engelman, A., and Craigie, R. (1992) Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro, J. Virol. 66, 6361-6369.
42. Kulkosky, J., Jones, K. S., Katz, R. A., Mack, J. P., and Skalka, A. M. (1992) Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases, Mol. Cell. Biol. 12, 2331-2338.
43. Leavitt, A. D., Shiue, L., and Varmus, H. E. (1993) Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro, J. Biol. Chem. 268, 2113-2119.