Robust two-stage approach to repeated measurements analysis of chronic ozone exposure in rats

Journal of Agricultural, Biological, and Environmental Statistics

Volumn 8, Issue 4, 2003, Pages 438-454

  Yeap, Beow Yong ^a   Catalano, Paul J ^b   Ryan, Louise M ^b   Davidian, Marie ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

ANOVA; Hierarchical nonlinear model; M estimation; Michaelis Menten; Mixed effects; Outlier

Indexed keywords

OZONE;

ANIMALIA;

EID: 5444259777     PISSN: 10857117     EISSN: None     Source Type: Journal    
DOI: 10.1198/1085711032552     Document Type: Article

References (20)

1. Boorman, G. A., Catalano, P. J., Jacobson, B. J., Kaden, D. A., Mellick, P. W., Nauss, K. M., and Ryan L. M. (1995), "Consequences of Prolonged Inhalation of Ozone on F344/N rats: Collaborative Studies, Part VI: Background and Project Design," Research Report No. 65, Health Effects Institute, Cambridge, MA.
2. Davidian, M., and Giltinan, D. M. (1993), "Some Simple Methods for Estimating Intraindividual Variability in Nonlinear Mixed Effects Models," Biometrics, 49, 59-73.
3. Davidian, M., and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, London: Chapman and Hall.
4. Farmer, S. G., and Hay, D. W. P. (1991), "Airway Epithelial Modulation of Smooth-muscle Function: the Evidence for Epithelium-derived Inhibitory Factor," in Lung Biology and Health and Disease 55, The Airway Epithelium: Physiology, Pathophysiology and Pharmacology, eds. S. G. Farmer and D. W. P. Hay, New York: Marcel Dekker.
5. Harkema, J. R., and Mauderly, J. L. (1994), "Consequences of Prolonged Inhalation of Ozone on F344/N rats: Collaborative Studies, Part V: Effects on Pulmonary Function," Research Report No. 65, Health Effects Institute, Cambridge, MA.
6. Huber, P. J. (1981), Robust Statistics, New York: Wiley.
7. Lindsey, J. K., and Lambert, P. (1998), "On the Appropriateness of Marginal Models for Repeated Measurements in Clinical Trials," Statistics in Medicine, 17, 447-469.
8. Lindstrom, M. J., and Bates, D. M. (1990), "Nonlinear Mixed Effects Model for Repeated Measures Data," Biometrics, 46, 673-687.
9. Lippman, M. (1989), "Health Effects of Ozone: A Critical Review," Journal of the Air Pollution Control Association, 39, 672-695.
10. Lippman, M. (1993), "Health Effects of Tropospheric Ozone: A Review of Recent Research Findings and their Implications to Ambient Air Quality Standards," Journal of Exposure Analysis and Environmental Epidemiology, 3, 103-129.
11. Plopper, C. G., Chu, F-P., Haselton, C. J., Peake, J., Wu, J., and Pinkerton, K. E. (1994a), "Dose-dependent Tolerance to Ozone I: Tracheobronchial Epithelial Reorganization in Rats after 20 Months' Exposure," American Journal of Pathology, 144, 404-421.
12. Plopper, C. G., Duan, X., Buckpitt, A. R., and Pinkerton, K. E. (1994b), "Dose-dependent Tolerance to Ozone IV: Site-specific Elevation in Antioxidant Enzymes in the Lungs of Rats Exposed for 90 Days or 20 Months," Toxicology and Applied Pharmacology, 127, 124-131.
13. Seber, G. A. F., and Wild, C. J. (1988), Nonlinear Regression, New York: Wiley.
14. Steimer, J.-L., Mallet, A., Golmard, J. L., and Boisvieux, J. F. (1984), "Alternative Approaches to Estimation of Population Pharmacokinetic Parameters: Comparison with the Nonlinear Mixed Effect Model," Drug Metabolism Reviews, 15, 265-292.
15. Szarek, J. L. (1994), "Consequences of Prolonged Inhalation of Ozone on F344/N rats: Collaborative Studies, Part II: Mechanical Properties, Responses to Bronchoactive Stimuli, and Eicosanoid Release in Isolated Large and Small Airways," Research Report No. 65, Health Effects Institute, Cambridge, MA.
16. Szarek, J. L., Stewart, N. L., Zhang, J. Z., Webb, J. A., Valentovic, M. A., and Catalano, P. (1995), "Contractile Responses and Structure of Small Bronchi Isolated from Rats after 20 Months' Exposure to Ozone," Fundamental and Applied Toxicology, 28, 199-208.
17. U.S. Environmental Protection Agency (1986), "Air Quality Criteria for Ozone," Washington, DC: U.S. EPA.
18. U.S. Environmental Protection Agency (1994), "Air Quality Criteria for Ozone and Related Photochemical Oxidants: External Review Draft, 1993," Washington, DC: U.S. EPA.
19. Vonesh, E. F., and Carter, R. L. (1992), "Mixed Effects Nonlinear Regression for Unbalanced Repeated Measures," Biometrics, 48, 1-18.
20. Yeap, B. Y., and Davidian, M. (2001), "Robust Two-stage Estimation in Hierarchical Nonlinear Models," Biometrics, 57, 266-272.