Suramin: Potential in acute liver failure

Expert Opinion on Investigational Drugs

Volumn 13, Issue 10, 2004, Pages 1361-1363

  Doggrell, Sheila A ^a  

^a Doggrell Biomedical Communications   (New Zealand)

Author keywords

Acute liver failure; Animal models of liver failure; Apoptosis; CD95; Suramin

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; APOPTOSIS INHIBITOR; ASPARTATE AMINOTRANSFERASE; CYCLOHEXIMIDE; DACTINOMYCIN; DAUNORUBICIN; DEXAMETHASONE; ENDOTOXIN; FAS ANTIGEN; FLUOROURACIL; GALACTOSAMINE; PARACETAMOL; SURAMIN; TUMOR NECROSIS FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER DISEASE; ANEMIA; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CLOTTING DISORDER; DRUG ERUPTION; DRUG MECHANISM; DRUG SELECTIVITY; FATIGUE; HUMAN; HYPERGLYCEMIA; HYPOCALCEMIA; LETHARGY; LEUKEMIA CELL LINE; LIVER FAILURE; LIVER ISCHEMIA; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; LIVER TRANSPLANTATION; MOUSE STRAIN; NEPHROTOXICITY; NEUROTOXICITY; NEUTROPENIA; NONHUMAN; REPERFUSION INJURY; VIRUS HEPATITIS;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; HUMANS; LIVER FAILURE, ACUTE; SURAMIN;

EID: 5444233100     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.13.10.1361     Document Type: Article

References (4)

1. EICHHORST ST, KRUEGER A, MÜERKÖSTER S et al.: Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat. Med. (2004) 10 602-609.
2. CANBAY A, FRIEDMAN S, GORES GJ: Apoptosis: the nexus of liver injury and fibrosis. Hepatology (2004) 39: 273-278.
3. WALCZAK H, KRAMMER PH: The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp. Cell. Res. (2000) 256: 58-66.
4. KAUR M, REED E, SARTOR O, DAHUT W, FIGG WD: Suramin's development: what did we learn? Invest. New Drugs (2002) 20: 209-219.