Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method

Journal of Separation Science

Volumn 31, Issue 16-17, 2008, Pages 3098-3105

  Nogueira, Daniele Rubert ^a   da Silva Sangol, Maximiliano ^a   da Silva, Lucélla Magalhães ^a   Dalmora, Sérgio Luiz ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

LC; MEKC; Rupatadine; Stability indicating method; Validation

Indexed keywords

DIFFUSERS (OPTICAL); FLUID DYNAMICS; FUSED SILICA; SILICA;

A STABILITIES; ANIONIC DETERGENTS; APPLIED VOLTAGES; BORATE BUFFERS; CAPILLARY TEMPERATURES; DEGRADATION STUDIES; DOSAGE FORMS; EFFECTIVE LENGTHS; HYDRODYNAMIC MODES; INTERNAL STANDARDS; LC; LC METHODS; MEKC; MEKC METHODS; NIMESULIDE; PHARMACEUTICAL FORMULATIONS; PHOTODIODE ARRAY DETECTORS; QUANTITATIVE ANALYSES; RUPATADINE; SDS SOLUTIONS; SILICA CAPILLARIES; VALIDATION;

DRUG PRODUCTS;

BORIC ACID; BUFFER; DETERGENT; NIMESULIDE; RUPATADINE; SILICON DIOXIDE;

ACCURACY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG FORMULATION; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; INTERMETHOD COMPARISON; MASS SPECTROMETRY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; STRUCTURE ANALYSIS; TABLET FORMULATION; VALIDATION STUDY;

ANIMALS; CHROMATOGRAPHY, MICELLAR ELECTROKINETIC CAPILLARY; CYPROHEPTADINE; DRUG STABILITY; L CELLS (CELL LINE); MICE; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TABLETS; TIME FACTORS;

EID: 54349118645     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200800254     Document Type: Article

References (24)

1. Saint-Martin, F., Dumur, J. P., Pérez, I., Izquierdo, I., J. Investig. Allergol. Clin. Immunol. 2004, 14, 34-40.
2. Caballero, R., Valenzuela, C., Longobardo, M., Tamargo, J., Delpón, E., Br. J. Pharmacol. 1999, 128, 1071-1081.
3. Guadaño, E. M., Serra-Batlles, J., Meseguer, J., Castillo, J. A. et al., Allergy 2004, 59, 766-771.
4. Merlos, M., Giral, M., Balsa, D., Ferrando, R. et al., J. Pharmacol. Exp. Ther. 1997, 280, 114-121.
5. Martínez-Cócera, C., De Molina, M., Martí-Guadaño, E., Póla, J. et al., J. Investig. Allergol. Clin. Immunol. 2005, 15, 22-29.
6. Solans, A., Carbó, M. L., Pena, J., Nadal, T. et al., Clin. Ther. 2007, 29, 900-908.
7. Izquierdo, I., Merlos, M., García-Rafanell, J., Drugs Today 2003, 39, 451-468.
8. Nogueira, D. R., D'Avila, F. B., Rolim, C. M. B., Dalmora, S. L., Chromatographia 2007, 66, 915-919.
9. Izquierdo, I., Nieto, C., Ramis, J., Cooper, M. et al., Methods Find. Exp. Clin. Pharmacol. 1997. 19(A), 189-203.
10. Picado, C., Expert Opin. Pharmacother. 2006, 7, 1989-2001.
11. Barbanoj, M. J., Garcia-Gea, C., Antonijoan, R., Isquierdo, I. et al., Hum. Psychopharm. Clin. 2006, 21, 13-26.
12. Tian, Y., Zhang, J., Lin, H., Liang, J. et al., J. Pharm. Biomed. Anal. 2007, 47, 899-906.
13. Altria, K. D., Elder, D., J. Chromatogr. A 2004, 1023, 1-14.
14. Holland, L. A., Chetwyn, N. P., Perkins, M. D., Lunte, S. M., Pharm. Res. 1997, 14, 372-387.
15. Morzunova, T. G., Pharm. Chem. J. - USSR 2006, 40, 158-170.
16. Holzgrabe, U., Brinz, D., Kopec, S., Weber, C., Bitar, Y., Electrophoresis 2006, 27, 2283-2292.
17. The United States Pharmacopoeia, 30th Ed.; Rockville, United States Convention, 2007.
18. Ciapetti, G., Granchi, D., Verri, P., Savarino, L. et al., Biomaterials 1996, 17, 1259-1264.
19. International Conference on Harmonization (ICH) of technical requirements for the registration of pharmaceutical for human use. Validation of analytical procedures: Text and methodology Q2(R1), 1-13 November, 2005, Geneva. Switzerland, http://www.ich.org.
20. International Conference on Harmonization (ICH) of technical requirements for the registration of pharmaceutical for human use. Stability testing of new drugs substance and products Q1A(R2), 1-18 February, 2003, Geneva, Switzerland, http://www.ich.org.
21. Süslü, I., Demircan, S., Altinöz, S., Kir, S., J. Pharm. Biomed. Anal. 2007, 44, 16-22.
22. Alsante, K. M., Ando, A., Brown, R., Ensing, J. et al., Adv. Drug Deliv. Rev. 2007, 59, 29-37.
23. Ermer, J., Ploss, H. J., J. Pharm. Biomed. Anal. 2005, 37, 859-870.
24. Shabir, G. A., J. Chromatogr. A 2003, 987, 57-66.