Serum markers in the diagnosis of tubal pregnancy

Clinics

Volumn 63, Issue 5, 2008, Pages 701-708

  Cabar, Fabio Roberto ^a   Fettback, Paula Beatriz ^a   Pereira, Pedro Paulo ^a   Zugaib, Marcelo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Ectopic pregnancy; First trimester pregnancy; Pregnancy associated plasma protein A; Progesterone; Vascular endothelial growth factor

Indexed keywords

BIOLOGICAL MARKER; CA 125 ANTIGEN; CREATINE KINASE; GESTAGEN; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROGESTERONE; VASCULOTROPIN A;

BLOOD; ECTOPIC PREGNANCY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; PREGNANCY; REVIEW; UTERINE TUBE PREGNANCY;

BIOLOGICAL MARKERS; CA-125 ANTIGEN; CREATINE KINASE; FEMALE; GESTATIONAL AGE; HUMANS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY, ECTOPIC; PREGNANCY, TUBAL; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROGESTERONE; PROGESTINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 54349094062     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322008000500021     Document Type: Review

References (53)

1. Lewis G, Drife J. "Why Mothers Die", Triennial Report 2000-2002. The Sixth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. London: RCOG Press, 2004.
2. Bjartling C, Osser S, Persson K. The frequency of salpingitis and ectopic pregnancy as epidemiologic markers of Chlamydia trachomatis. Acta Obstet Gynecol Scand. 2000;79:123-8.
3. Centers for Disease Control and Prevention. Ectopic Pregnancy - United States, 1990-1992. MMWR Morb Mortal Wkly Rep. 1995;44:46-8.
4. Job-Spira N, Collet P, Coste J, Brémont A, Lauman B. Risk factors for ectopic pregnancy. Results of a case-control study in the Rhone-Alpes region. Contracept Fertil Sex. 1993;21:307-12.
5. Ankum WM, Mol BW, Van der Veen F, Bossuyt PM. Risk factors for ectopic pregnancy: a meta-analysis. Fertil Steril 1996;65:1093-9.
6. Bouyer J, Coste J, Shojaei T, Pouly JL, Fernandez H, Gerbaud L, et al. Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol. 2003;157:185-94.
7. Pereira PP, Cabar FR, Raiza LC, Roncaglia MT, Zugaib M. Emergency contraception and ectopic pregnancy: report of 2 cases. Clinics. 2005;60:497-500.
8. Cabar FR, Pereira PP, Zugaib M. Intrauterine pregnancy after salpingectomy for tubal pregnancy due to emergency contraception: a case report. Clinics. 2007;62:641-2.
9. Chow WH, Daling JR, Cates W, Greenberg RS. Epidemiology of ectopic pregnancy. Epidemiol Rev. 1987;9:70-94.
10. Coste J, Job-Spira N, Fernandez H, Papiernik E, Spira A. Risk factors for ectopic pregnancy: a case-control study in France, with special focus on infectious factors. Am J Epidemiol. 1991;133:839-49.
11. Fernandez H, Coste J, Job-Spira N. Controlled ovarian hyperstimulation as a risk factor for ectopic pregnancy. Obstet Gynecol. 1991;78:656-9.
12. Daponte A, Pournaras S, Zintzaras E, Kallitsaris A, Lialios G, Maniatis AN, et al. The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. Hum Reprod. 2005;20:3163-6.
13. Mueller MD, Raio L, Spoerri S, Ghezzi F, Dreher E, Bersinger NA. Novel placental and nonplacental serum markers in ectopic versus normal intrauterine pregnancy. Fertil Steril. 2004;81:1106-11.
14. Kucera-Sliutz E, Schiebel I, Konig F, Leodolter S, Sliutz G, Koelbl H. Vascular endothelial growth factor (VEGF) and discrimination between abnormal intrauterine and ectopic pregnancy. Hum Reprod. 2002;17:3231-4.
15. Felemban A, Sammour A, Tulandi T. Serum vascular endothelial growth factor as a possible marker for early ectopic pregnancy. Hum Reprod. 2002;17:490-2.
16. Abbott J, Emmans LS, Lowenstein SR. Ectopic pregnancy: ten common pitfalls in diagnosis. Am J Emerg Med. 1990; 8:515-22.
17. Cacciatore B, Stenman UH, Ylostalo P. Early screening for ectopic pregnancy in high-risk symptom-free women. Lancet. 1994;343(8896):517-8.
18. Tulandi T, Saleh A, Morris D, Jacobs HS, Payne NN, Tan SL. Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome. Fertil Steril. 2000;74:585-8.
19. Kadar N, DeCherney AH, Romero R. Receiver operating characteristic (ROC) curve analysis of the relative efficacy of single and serial chorionic gonadotropin determinations in the early diagnosis of ectopic pregnancy. Fertil Steril.1982;37:542-7.
20. Sinosich MJ, Grudzinskas JG, Saunders DM. Placental proteins in the diagnosis and evaluation of the «elusive» early pregnancy. Obstet Gynecol Surv. 1985;40:273-82.
21. Scheid DC, Ramakrishnan K. Determining ectopic pregnancy risk using progesterone levels. Am Fam Physician 2006;73:1892.
22. McCord ML, Muram D, Buster JE, Arheart KL, Stovall TG, Carson SA. Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Fertil Steril. 1996;66:513-6.
23. Mol BW, Lijmer JG, Ankum WM, van der Veen F, Bossuyt PM. The accuracy of single serum progesterone measurement in the diagnosis of ectopic pregnancy: a meta-analysis. Hum Reprod. 1998;13:3220-7.
24. Dart R, Ramanujam P, Dart L. Progesterone as a predictor of ectopic pregnancy when the ultrasound is indeterminate. Am J Emerg Med. 2002;20:575-9.
25. Spitzer M, Pinto AB, Dasgupta R, Benjamin F. Early diagnosis of ectopic pregnancy: can we do it accurately using a biochemical profile? J Womens Health Gend Based Med. 2000;9:537-44.
26. Chandra L, Jain A. Maternal serum creatine kinase as a biochemical marker of tubal pregnancy. Int J Gynaecol Obstet. 1995;49:21-3.
27. Saha PK, Gupta I, Ganguly NK. Evaluation of serum creatine kinase as a diagnostic marker for tubal pregnancy. Aust NZJ Obstet Gynaecol 1999;39:366-7.
28. Farquhar CM. Ectopic pregnancy. Lancet. 2005;366:583-91.
29. Stovall TG, Kellerman AL, Ling FW, Buster JE. Emergency department diagnosis of ectopic pregnancy. Ann Emerg Med. 1990;19:1098-103.
30. Perkins SL, Al-Ramahi M, Claman P. Comparison of serum progesterone as an indicator of pregnancy nonviability in spontaneously pregnant emergency room and infertility clinic patient populations. Fertil Steril. 2000;73:499-504.
31. Buckley RG, King KJ, Disney JD, Riffenburgh RH, Gorman JD, Klausen JH. Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients. Ann Emerg Med. 2000;36:95-100.
32. Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D. Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound Obstet Gynecol. 2004;23:552-6.
33. Budowick M, Johnson TR, Jr., Genadry R, Parmley TH, Woodruff JD. The histopathology of the developing tubal ectopic pregnancy. Fertil Steril. 1980;34:169-71.
34. Sinosich MJ, Ferrier A, Teisner B, Porter R, Westergaard JG, Saunders DM, et al. Circulating and tissue concentrations of pregnancy-associated plasma protein-A (PAPP-A) in tubal ectopic gestation. Clin Reprod Fertil. 1985;3:311-7.
35. Sjoberg J. Pregnancy-associated plasma protein A in pregnancy-related gynecologic emergency. Hum Reprod. 1987;2:615-6.
36. Tornehave D, Chemnitz J, Westergaard JG, Teisner B, Poulsen HK, Bolton AE, et al. Placental proteins in peripheral blood and tissues of ectopic pregnancies. Gynecol Obstet Invest 1987;23:97-102.
37. Torry DS, Torry RJ. Angiogenesis and the expression of vascular endothelial growth factor in endometrium and placenta. Am J Reprod Immunol. 1997;37:21-9.
38. Daniel Y, Geva E, Lerner-Geva L, Eshed-Englender T, Gamzu R, Lessing JB, et al. Levels of vascular endothelial growth factor are elevated in patients with ectopic pregnancy: is this a novel marker? Fertil Steril. 1999;72:1013-7.
39. Ugurlu EN, Ozaksit G, Karaer A, Zulfikaroglu E, Atalay A, Ugur M. The value of vascular endothelial growth factor, pregnancy-associated plasma protein-A, and progesterone for early differentiation of ectopic pregnancies, normal intrauterine pregnancies, and spontaneous miscarriages. Fertil Steril. 2008 Apr 8. [Epub ahead of print].
40. Gerton GL, Fan XJ, Chittams J, Sammel M, Hummel A, Strauss JF, Barnhart K. A serum proteomics approach to the diagnosis of ectopic pregnancy. Ann N Y Acad Sci. 2004;1022:306-16.
41. Lam PM, Briton-Jones C, Cheung CK, Leung SW, Cheung LP, Haines C. Increased messenger RNA expression of vascular endothelial growth factor and its receptors in the implantation site of the human oviduct with ectopic gestation. Fertil Steril. 2004;82:686-90.
42. Katsikis I, Rousso D, Farmakiotis D, Kourtis A, Diamanti-Kandarakis E, Zournatzi-Koiou V, et al. Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. Am J Obstet Gynecol. 2006;194:86-91.
43. Vitoratos N, Gregoriou O, Papadias C, Konidaris S, Kalogirou D, Kalampokis D, et al. Clinical value of creatinine kinase in the diagnosis of ectopic pregnancy. Gynecol Obstet Invest. 1998;46:80-3.
44. Kurzel RB, Mazdisnian F, Paige S, Liu P. Serum creatine kinase is not a reliable indicator of ectopic pregnancy. Int J Fertil Womens Med. 2001;46:300-3.
45. Jacobs I, Bast RC Jr. The CA 125 tumour-associated antigen: a review of the literature. Hum Reprod. 1989;4:1-12.
46. Check JH, Vetter BH. A challenge to the concept of tubal reflux to explain the rise and fall of CA125 in serum during the first trimester. Hum Reprod. 1995;10:674-6.
47. Hornstein MD, Check JH, Hill JA. Serum CA 125 levels and spontaneous abortion. Am J Obstet Gynecol. 1995;172:695-9.
48. Katsikis I, Rousso D, Farmakiotis D, Kourtis A, Diamanti-Kandarakis E, Panidis D. Receiver operator characteristics and diagnostic value of progesterone and CA-125 in the prediction of ectopic and abortive intrauterine gestations. Eur J Obstet Gynecol Reprod Biol. 2006;125:226-32.
49. Kobayashi F, Takashima E, Sagawa N, Mori T, Fujii S. Maternal serum CA125 levels in early intrauterine and tubal pregnancies. Arch Gynecol Obstet. 1993;252:185-9.
50. Sadovsky Y, Pineda J, Collins JL. Serum CA-125 levels in women with ectopic and intrauterine pregnancies. J Reprod Med. 1991;36:875-8.
51. Schmidt T, Rein DT, Foth D, Eibach HW, Kurbacher CM, Mallmann P, et al.
52. Prognostic value of repeated serum CA 125 measurements in first trimester pregnancy. Eur J Obstet Gynecol Reprod Biol. 2001;97:168-73.
53. Condous G, Kirk E, Syed A, Van Calster B, Van Huffel S, Timmerman D, et al. Do levels of serum cancer antigen 125 and creatine kinase predict the outcome in pregnancies of unknown location? Hum Reprod. 2005;20:3348-54.