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Volumn 15, Issue 4, 2008, Pages 14-19

Defining the optimal treatment strategy for localized prostate cancer patients: A survey of ongoing studies at the National Cancer Institute of Canadia Clinical Trials Group

Author keywords

Clinical trials; Localized prostate cancer; Risk estimation

Indexed keywords

ANTIANDROGEN; DOCETAXEL; PROSTATE SPECIFIC ANTIGEN;

EID: 54349090092     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (7)

References (30)
  • 1
    • 35448998256 scopus 로고    scopus 로고
    • Canadian Cancer Society and the National Cancer Institute of Canada, Toronto: Canadian Cancer Society;
    • Canadian Cancer Society and the National Cancer Institute of Canada. Canadian Cancer Statistics 2007. Toronto: Canadian Cancer Society; 2007.
    • (2007) Canadian Cancer Statistics 2007
  • 2
    • 0038275923 scopus 로고    scopus 로고
    • Lead times and overdetection due to prostate-specific antigen screening: Estimates from the European Randomized Study of Screening for Prostate Cancer
    • Draisma C, Boer R, Otto SJ, et al. Lead times and overdetection due to prostate-specific antigen screening: estimates from the European Randomized Study of Screening for Prostate Cancer. J Natl Cancer Inst 2003;95:868-78.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 868-878
    • Draisma, C.1    Boer, R.2    Otto, S.J.3
  • 3
    • 0037014792 scopus 로고    scopus 로고
    • Overdiagnosis due to prostate-specific antigen screening: Lessons from U.S. prostate cancer incidence trends
    • Etzoni R, Penson DF, Legler JM, et al. Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J Natl Cancer Inst 2002;94:981-90.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 981-990
    • Etzoni, R.1    Penson, D.F.2    Legler, J.M.3
  • 4
    • 0028158141 scopus 로고
    • Results of conservative management of clinically localized prostate cancer
    • Chodak GW, Thisted RA, Gerber GS, et al. Results of conservative management of clinically localized prostate cancer. N Engl J Med 1994;330:242-8.
    • (1994) N Engl J Med , vol.330 , pp. 242-248
    • Chodak, G.W.1    Thisted, R.A.2    Gerber, G.S.3
  • 5
    • 0031028711 scopus 로고    scopus 로고
    • Fifteen-year survival in prostate cancer. A prospective, population-based study in Sweden
    • Johansson JE, Holmberg L, Johansson S, Bergström R, Adami HO. Fifteen-year survival in prostate cancer. A prospective, population-based study in Sweden. JAMA 1997;277:467-71.
    • (1997) JAMA , vol.277 , pp. 467-471
    • Johansson, J.E.1    Holmberg, L.2    Johansson, S.3    Bergström, R.4    Adami, H.O.5
  • 6
    • 17844402699 scopus 로고    scopus 로고
    • 20-Year outcomes following conservative management of clinically localized prostate cancer
    • Albertsen PC, Hanley JA, Fine J. 20-Year outcomes following conservative management of clinically localized prostate cancer. JAMA 2005;293:2095-101.
    • (2005) JAMA , vol.293 , pp. 2095-2101
    • Albertsen, P.C.1    Hanley, J.A.2    Fine, J.3
  • 7
    • 36348933946 scopus 로고    scopus 로고
    • Active surveillance for favorable risk prostate cancer: Rationale, risks, and results
    • Klotz L. Active surveillance for favorable risk prostate cancer: rationale, risks, and results. Urol Oncol 2007;25:505-9.
    • (2007) Urol Oncol , vol.25 , pp. 505-509
    • Klotz, L.1
  • 8
    • 0037072063 scopus 로고    scopus 로고
    • Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): A phase III randomised trial
    • Bolla M, Collette L, Blank L, et al. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet 2002;360:103-8.
    • (2002) Lancet , vol.360 , pp. 103-108
    • Bolla, M.1    Collette, L.2    Blank, L.3
  • 9
    • 0642311912 scopus 로고    scopus 로고
    • on behalf of the Radiation Therapy Oncology Group. Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: The Radiation Therapy Oncology Group Protocol 92-02
    • Hanks GE, Pajak TF, Porter A, et al. on behalf of the Radiation Therapy Oncology Group. Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: the Radiation Therapy Oncology Group Protocol 92-02. J Clin Oncol 2003;21:3972-8.
    • (2003) J Clin Oncol , vol.21 , pp. 3972-3978
    • Hanks, G.E.1    Pajak, T.F.2    Porter, A.3
  • 10
    • 16344385883 scopus 로고    scopus 로고
    • Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma - long-term results of phase III RTOG 85-31
    • Pilepich MV, Winter K, Lawton CA, et al. Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma - long-term results of phase III RTOG 85-31. Int J Radiat Oncol Biol Phys 2005;61:1285-90.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 1285-1290
    • Pilepich, M.V.1    Winter, K.2    Lawton, C.A.3
  • 12
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004;351:1513-20.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 13
    • 4744366279 scopus 로고    scopus 로고
    • on behalf of the TAX 327 Investigators. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, et al. on behalf of the TAX 327 Investigators. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004;351:1502-12.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    de Wit, R.2    Berry, W.R.3
  • 14
    • 2942613326 scopus 로고    scopus 로고
    • Phase II trial of neoadjuvant docetaxel before radical prostatectomy for locally advanced prostate cancer
    • Dreicer R, Magi-Galluzzi C, Zhou M, et al. Phase II trial of neoadjuvant docetaxel before radical prostatectomy for locally advanced prostate cancer. Urology 2004;63:1138-42.
    • (2004) Urology , vol.63 , pp. 1138-1142
    • Dreicer, R.1    Magi-Galluzzi, C.2    Zhou, M.3
  • 15
    • 8344228599 scopus 로고    scopus 로고
    • Single-agent chemotherapy with docetaxel significantly reduces PSA levels in patients with high-grade localized prostate cancers
    • Berger AP, Niescher M, Fischer-Colbrie R, Pelzer A, Bartsch G, Horninger W. Single-agent chemotherapy with docetaxel significantly reduces PSA levels in patients with high-grade localized prostate cancers. Urol Int 2004;73:110-12.
    • (2004) Urol Int , vol.73 , pp. 110-112
    • Berger, A.P.1    Niescher, M.2    Fischer-Colbrie, R.3    Pelzer, A.4    Bartsch, G.5    Horninger, W.6
  • 16
    • 18444376147 scopus 로고    scopus 로고
    • Docetaxel followed by hormone therapy in men experiencing increasing prostate-specific antigen after primary local treatments for prostate cancer
    • Hussain A, Dawson N, Amin P, et al. Docetaxel followed by hormone therapy in men experiencing increasing prostate-specific antigen after primary local treatments for prostate cancer. J Clin Oncol 2005;23:2789-96.
    • (2005) J Clin Oncol , vol.23 , pp. 2789-2796
    • Hussain, A.1    Dawson, N.2    Amin, P.3
  • 17
    • 22344446693 scopus 로고    scopus 로고
    • Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer
    • Febbo PG, Richie JP, George DJ, et al. Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer. Clin Cancer Res 2005;11:5233-40.
    • (2005) Clin Cancer Res , vol.11 , pp. 5233-5240
    • Febbo, P.G.1    Richie, J.P.2    George, D.J.3
  • 18
    • 0031035693 scopus 로고    scopus 로고
    • Bcl2 is the guardian of microtubule integrity
    • Haldar S, Basu A, Croce CM. Bcl2 is the guardian of microtubule integrity. Cancer Res 1997;57:229-33.
    • (1997) Cancer Res , vol.57 , pp. 229-233
    • Haldar, S.1    Basu, A.2    Croce, C.M.3
  • 19
    • 0344509644 scopus 로고    scopus 로고
    • A phase II trial of Taxotere in hormone refractory prostate cancer: Correlation of antitumour activity to phosphorylation of Bcl-2
    • abstract 1237, Available online at:, cited May 8, 2008
    • Friedland D, Cohen J, Miller R, et al. A phase II trial of Taxotere in hormone refractory prostate cancer: correlation of antitumour activity to phosphorylation of Bcl-2 [abstract 1237]. Proc Am Soc Clin Oncol 1999;18:. [Available online at: www.asco.org/ASCO/ Abstracts+%26+Virtual+Meeting/Abstracts?&vmview= abst_detail_view&confID=17&abstractID=15490; cited May 8, 2008]
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Friedland, D.1    Cohen, J.2    Miller, R.3
  • 20
    • 0034112089 scopus 로고    scopus 로고
    • Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo
    • Miyake H, Chi KN, Gleave ME. Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo. Clin Cancer Res 2000;6:1655-63.
    • (2000) Clin Cancer Res , vol.6 , pp. 1655-1663
    • Miyake, H.1    Chi, K.N.2    Gleave, M.E.3
  • 21
    • 0029077281 scopus 로고
    • Overexpression of Bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo
    • Raffo AJ, Perlman H, Chen MW, Day ML, Streitman JS, Buttyan R. Overexpression of Bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Res 1995;55:4438-45.
    • (1995) Cancer Res , vol.55 , pp. 4438-4445
    • Raffo, A.J.1    Perlman, H.2    Chen, M.W.3    Day, M.L.4    Streitman, J.S.5    Buttyan, R.6
  • 22
    • 27644506552 scopus 로고    scopus 로고
    • Timing is everything: Preclinical evidence supporting simultaneous rather than sequential chemohormonal therapy for prostate cancer
    • Eigl BJ, Eggener SE, Baybik J, et al. Timing is everything: preclinical evidence supporting simultaneous rather than sequential chemohormonal therapy for prostate cancer. Clin Cancer Res 2005;11:4905-11.
    • (2005) Clin Cancer Res , vol.11 , pp. 4905-4911
    • Eigl, B.J.1    Eggener, S.E.2    Baybik, J.3
  • 23
    • 54349101377 scopus 로고    scopus 로고
    • Winquist E, Chi KN, Chin J, et al. Multicenter phase II study of combined neoadjuvant docetaxel and androgen ablation (ADT) prior to radical prostatectomy (RP) for patients (pts) with high risk localized prostate cancer (LCAP): pathologic outcomes and 3-year follow-up analyses [abstract 5002]. Proc Am Soc Clin Oncol 2007;25:. [Available online at: www.asco.org/ASCO/Abstracts+%26+Virtual+Meeting/ Abstracts?&vmview=abst_detail_view&confID=47&abstractID= 30613; cited May 8, 2008]
    • Winquist E, Chi KN, Chin J, et al. Multicenter phase II study of combined neoadjuvant docetaxel and androgen ablation (ADT) prior to radical prostatectomy (RP) for patients (pts) with high risk localized prostate cancer (LCAP): pathologic outcomes and 3-year follow-up analyses [abstract 5002]. Proc Am Soc Clin Oncol 2007;25:. [Available online at: www.asco.org/ASCO/Abstracts+%26+Virtual+Meeting/ Abstracts?&vmview=abst_detail_view&confID=47&abstractID= 30613; cited May 8, 2008]
  • 24
    • 54349113188 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant docetaxel and androgen suppression (AS) plus radiation therapy (RT) for high-risk localized prostate cancer (HRLCAP) [abstract 4631]
    • Available online at:, cited May 8, 2008
    • McKenzie MR, Chi KN, Neville A, et al. Phase II study of neoadjuvant docetaxel and androgen suppression (AS) plus radiation therapy (RT) for high-risk localized prostate cancer (HRLCAP) [abstract 4631]. Proc Am Soc Clin Oncol 2006;24:. [Available online at: www.asco.org/ASCO/Abstracts+%2 6+Virtual+Meeting/Abstracts?&vmview= abst_detail_view&confID=40&abstractID=34492; cited May 8, 2008]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • McKenzie, M.R.1    Chi, K.N.2    Neville, A.3
  • 25
    • 54349100345 scopus 로고    scopus 로고
    • Cancer surgery
    • Chapter 2, Tu JV, Pinfold SP, McColgan P, Laupacis A, eds, Toronto: Institute for Clinical Evaluative Sciences; April, Available online at:, cited June 9, 2008
    • Hodgson D, Urbach D, Przybysz R, Gong Y, Sullivan T, Rabeneck L. Cancer surgery. Chapter 2. In: Tu JV, Pinfold SP, McColgan P, Laupacis A, eds. Access to Health Services in Ontario. Toronto: Institute for Clinical Evaluative Sciences; April 2005: 10. [Available online at: www.ices.on.ca/WebBuild/site/ices-internet-upload/file_collection/ Chp2_v5new.pdf; cited June 9, 2008]
    • (2005) Access to Health Services in Ontario , pp. 10
    • Hodgson, D.1    Urbach, D.2    Przybysz, R.3    Gong, Y.4    Sullivan, T.5    Rabeneck, L.6
  • 26
    • 23744493443 scopus 로고    scopus 로고
    • Postoperative radiotherapy after radical prostatectomy: A randomised controlled trial (EORTC trial 22911)
    • Bolla M, van Poppel H, Collette L, et al. Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). Lancet 2005;366:572-8.
    • (2005) Lancet , vol.366 , pp. 572-578
    • Bolla, M.1    van Poppel, H.2    Collette, L.3
  • 27
    • 33751018522 scopus 로고    scopus 로고
    • Adjuvant radiotherapy for pathologically advanced prostate cancer: A randomized clinical trial
    • Thompson IM Jr, Tangen CM, Paradelo J, et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial. JAMA 2006;296:2329-35.
    • (2006) JAMA , vol.296 , pp. 2329-2335
    • Thompson Jr, I.M.1    Tangen, C.M.2    Paradelo, J.3
  • 28
    • 47949109017 scopus 로고    scopus 로고
    • Phase III results of adjuvant radiotherapy (RT) versus wait-and-see (ws) in patients with pT3 prostate cancer following radical prostatectomy (RP)(ARO 96-02/AUO AP 09/ 95)
    • abstract 5060, Available online at:, cited May 8, 2008
    • Wiegel T, Bottke D, Willich N, et al. Phase III results of adjuvant radiotherapy (RT) versus wait-and-see (ws) in patients with pT3 prostate cancer following radical prostatectomy (RP)(ARO 96-02/AUO AP 09/ 95) [abstract 5060]. Proc Am Soc Clin Oncol 2007;25:. [Available online at: www.asco.org/ASCO/Abstracts+%26+Virtual+Meeting/Abstracts? &vmview=abst_detail_view&confID=47&abstractID=35176; cited May 8, 2008]
    • (2007) Proc Am Soc Clin Oncol , vol.25
    • Wiegel, T.1    Bottke, D.2    Willich, N.3


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