Pineal melatonin-immune system interaction

Frontiers of Hormone Research

Volumn 21, Issue , 1996, Pages 71-83

  Poon, A M S ^a,b   Pang, S F ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 54249124159     PISSN: 03013073     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (121)

1. Jankovic BD, Isakovic K, Petrovic S: Effect of pinealectomy on immune reactions in the rat. Immunology 1970;18:1-16.
2. Csaba G, Barath P: Morphological changes in the lung, thymus and the thyroid gland after postnatal extirpation of pineal body. Endocrinol Exp 1975;9:59-67.
3. Csaba F, Bodoky M, Fischer J, Acs T: The effect of pinealectomy and thymectomy on the immune capacity of the rat. Experientia 1965;22:168-175.
4. Bindoni M, Cambria A: Effects of pinealectomy on the in vivo and in vitro biosynthesis of nucleic acids and on the mitotic rate in some organs of the rat. Arch Sci Biol 1968;52:271-283.
5. Relia W, Lapin V: Immunocompetence of pinealectomized and simultaneously pinealectomized and thymectomized rats. Oncology 1976;33:3-6.
6. Kuci S, Becker J, Veit G, Handgretinger R, Attanasio A, Bruchelt G, Treuner E, Niethammer D, Gupta D: Circadian variations in the immunomodulatory role of the pineal gland. Neuroendocrinol Lett 1988;10:65-79.
7. Haus E, Lakatua DJ, Swoyer J, Sackett-Lundeen L: Chronobiology in hematology and immunology. Am J Anat 1983;168:467-517.
8. Fernandes G, Yunis EJ, Halberg F: Circadian aspect of immune responses in the mouse; in McGovern JP, Smolensky MH, Reinberg A (eds): Chronobiology in Allergy and Immunology. Springfield, Thomas, 1977, pp 233-249.
9. Fernandes G, Halberg F, Good APA: Circadian rhythm in T, B and natural killer cells; in Smolensky MH (ed): Recent Advances in the Chronobiology of Allergy and Immunology. Oxford, Pergamon, 1980, pp 289-299.
10. Angeli A, Gatti G, Sartori ML, Masera RG: Chronobiological aspects of neuroendocrine-immune network: regulation of human natural killer cell activity as a model. Chronobiologia 1992;19:93-110.
11. Maestroni GJM: The immunoneuroendocrine role of melatonin. J Pineal Res 1993;14:1-10.
12. Maestroni GJM, Pierpaoli W: Pharmacological control of the hormonally mediated immune response; in Ader R (ed): Psychoneuroimmunology. New York, Academic Press, 1981, pp 405-428.
13. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal gland in immunity: Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol 1986;13:19-30.
14. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin Exp Immunol 1987;68:384-391.
15. Maestroni GJM, Conti A, Pierpaoli W: The pineal gland and the circadian opiatergic immunoregulatory role of melatonin. Ann NY Acad Sci 1987;496:67-77.
16. Maestroni GJM, Conti A, Pierpaoli W: Pineal melatonin: Its fundamental immunoregulatory role in aging and cancer. Ann NY Acad Sci 1988;521:140-148.
17. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 1988;63:465-469.
18. Maestroni GJM, Conti A, Pierpaoli W: Melatonin, stress and the immune system; in Reiter RJ (ed): Pineal Research Review. New York, Liss, 1989, pp 203-223.
19. Ben-Nathan D, Maestroni GJM, Lustig S, Conti A: Protective effects of melatonin in mice infected with encephalitis virus. Arch Virol 1995;140:223-230.
20. Maestroni GJM, Covacci V, Conti A: Haematopoietic rescue via T-cell dependent endogenous GM-CSF by the pineal neurohormone melatonin in tumour bearing mice. Cancer Res 1994;54: 2429-2432.
21. Sainz RM, Mayo JC, Uria H, Kotier M, Antolin I, Roadriguez C, Menedez-Palaez AZ: The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes. J Pineal Res 1995; 19:178-188.
22. Becker J, Veit G, Handgretinger R, Attansio A, Bruchett G, Treuner I, Niethammer D, Das Gupta TK: Circadian variations in the immunomodulatory role of the pineal gland. Neuroendocrinol Lett 1988;10:65-72.
23. Caroleo MC, Frasca D, Nistico G, Doria G: Melatonin as immunomodulator in immunodeficient mice. Immunopharmacology 1992;23:81-89.
24. Lissoni P, Morabito F, Esposti G, Esposti D, Ripamonti G, Fraschini F: A study on the thymus-pineal axis: Interactions between thymic hormones and melatonin secretion. Acta Med Auxol 1988; 20:35-39.
25. Del Gobbo V, Libri V, Villani N, Calio R, Nistico G: Pinealectomy inhibits interleukin-2 production and natural killer activity in mice. Int J Immunopharmacol 1992;11:567-577.
26. Giordano M, Palermo MS: Melatonin-induced enhancement of antibody dependent cellular cytotoxicity. J Pineal Res 1991;10:117-121.
27. Champney TH, McMurray DN: Spleen morphology and lymphoproliferative activity in short photoperiod exposed hamsters; in Fraschini F, Reiter RJ (eds): Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. London, Plenum, 1991, pp 219-225.
28. Muscettola M, Grasso G, Fanetti G, Tanganelli C, Borghesi-Nicoletti C: Melatonin and modulation of inteferon-γ production. Neuropeptides 1992;22:46.
29. Pioli C, Caroleo MC, Nistico G, Doria G: Melatonin increases antigen presentation and amplifies specific and non specific signals for T-cell proliferation. Int J Immunopharmacol 1993;15:463-468.
30. Morrey KM, McLachlan JA, Serkin CD, Bakouche O: Activation of human monocytes by the pineal hormone melatonin. J Immunol 1994;153:2671-2680.
31. Maestroni GJ: T-helper-2 lymphocytes as a peripheral target of melatonin. J Pineal Res 1995;18: 84-89.
32. Artz EA, Fernandez-Castello S, Finocchiaro LME, Criscuolo ME, Diaz A, Finkielman S, Nahmod VE: Immunomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-γ synthesis by human peripheral blood mononuclear cells. J Clin Immunol 1988;8:513-520.
33. Lewinski A, Zelazowsky A, Sewerynek E, Zerek-Melen G, Szudlinski M: Melatonin-induced immunosuppression of human lymphocyte natural killer activity in vitro. J Pineal Res 1989;7:153-164.
34. Persengiev SP, Kyurkchiev S: Selective effect of melatonin on the proliferation of lymphoid cells. Int J Biochem 1993;3:441-444.
35. Di Stefano A, Paulesu L: Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors. J Pineal Res 1994;17:164-169.
36. Giannessi F, Bianchi F, Dolfi A, Lupetti M: Changes in the chicken bursa of Fabricius and immune response after treatment with melatonin. In Vivo 1992;6:507-512.
37. Skwarlo-Sonto K, Thaela MJ, Midura M, Lech B, Gluchowska B, Drela N, Kozlowska E, Kowalczyk R: Exogenous melatonin modifies the circadian rhythm but does not increase the level of some immune parameters in the chicken. J Pineal Res 1992;12:27-34.
38. Skwarlo-Sonta K, Rosolowska-Huszcz D, Sidorkiewicz E: Diurnal changes in certain immunity indices and plasma corticosterone concentration in White Leghorn chickens. Acta Physiol Pol 1983; 34:445-456.
39. Rosolowska-Husczcz D, Thaila MJ, Jagura M, Stepien D, Skwarlo-Sonta K: Pineal influence on the diurnal rhythm of nonspecific immunity indices in chickens. J Pineal Res 1991;10:190-195.
40. Skwarlo-Sonta K, Thaela MJ, Gluchowska B, Stepien D, Jagura M: Effect of dose and time of melatonin injection on the diurnal rhythm of immunity in chicken. J Pineal Res 1991;10:30-35.
41. Singh DV, Turner CW: Effect of melatonin upon thyroid hormone secretion rate and endocrine glands of chicks. Proc Soc Exp Biol 1967;125:407-411.
42. Jankovic BD, Nikolic P, Cupic V, Hladni K: Pineal gland and immune system: Immune functions in the chicken embryo pinealectomized at 96 hours of incubation. Ann NY Acad Sci 1994;719: 410-418.
43. Rodriguez AB, Lea RW: Effect of pinealectomy upon the nonspecific immune response of the ring-dove (Streptopelia risoria). J Pineal Res 1994;16:159-166.
44. Guerrero JM, Reiter RJ: A brief survey of pineal gland-immune system interrelationships. Endocr Res 1992;18:91-113.
45. Finochiaro LME, Artz ES, Fernandez-Castelo S, Crisculolo M, Finkielman S, Nahmod V: Serotonin and melatonin synthesis in peripheral mononuclear cells: Stimulation of gamma interferon as part of an immunostimulatory pathway. J Interferon Res 1988;8:705-716.
46. Withyachumnarnkul B, Reiter RJ, Lerchl A, Nonaka KO, Stokkan KA: Evidence that interferon-γ alters pineal metabolism both indirectly via sympathetic nerves and directly on pinealocytes. Int J Biochem 1991;12:1397-1401.
47. Withyachumnarnkul B, Nonaka KO, Santana C, Attia AM, Reiter RJ: Interferon-γ modulates melatonin production in rat pineal glands in organ culture. J Inteferon Res 1990;10:403-411.
48. Lissoni P, Barni S, Archili C, Cattaneo G, Rovelli F, Conti A, Maestroni GJM, Tancini G: Endocrine effects of a 24-hour intravenous infusion of interleukin-2 in the immunotherapy of cancer. Anticancer Res 1990;10:753-758.
49. Maestroni GJM, Conti A: Melatonin and the immune system; in Touitou Y, Adrent J, Pevet P (eds): Melatonin and the Pineal Gland: From Basic Science to Clinical Application. Amsterdam, Excerpta Medica, 1992, pp 295-302.
50. Maestroni GJM, Conti A: Melatonin in relation to the immune system; in Yu HS, Reiter RJ (eds): Melatonin: Biosynthesis, Physiological Effects and Clinical Applications. Boca Raton, CRC Press, 1992, pp 289-310.
51. Maestroni GJM, Conti A: Beta-endorphin and dynorphin mimic the circadian immunoenhancing and anti-stress effects of melatonin. Int J Immunopharmacol 1989;11:333-340.
52. Maestroni GJM, Conti A: The pineal neurohormone melatonin stimulates activated CD4+, Thy-1+ cells to release opioid agonist(s) with immunoenhancing and antistress properties. J Neuroimmunol 1990;28:167-176.
53. Maestroni GJM, Conti A: Anti-stress role of the melatonin-immuno-opioid network. Evidence for a physiological mechanism involving T cell-derived, immunoreactive beta-endorphin and metenkephalin binding to thymic opioid receptors. Int J Neurosci 1991;61:289-298.
54. Saksela E, Timonen T: Cellular interactions in the agumentation of human NK activity by interferon. Ann NY Acad Sci 1980;350,102-111.
55. Kuribayashi K, Grillis S, Kern DE, Henney CS: Murine NK cell culture: Effects of interleukin-2 and inteferon on cell growth and cytotoxic reactivity. J Immunol 1981;126:2321-2327.
56. Nelson RJ, Demas GE, Klei SL, Kriegsfeld LJ: The influence of season, photoperiod, and pineal melatonin on immune fuction. J Pineal Res 1995;19:149-165.
57. Vaughan MK, Hubbard GB, Champney GM, Vaughan GM, Little JC, Reiter RJ: Splenic hypertrophy and extramedullary haematopoiesis induced in male Syrian hamsters by short photoperiod or melatonin injections and reversed by melatonin pellets or pinealectomy. Am J Anat 1987;179: 131-136.
58. Brainard GC, Knobler RL, Podolin PL, Lavasa M, Lublin FD: Neuroimmunology: Modulation of the hamster immune system by photoperiod. Life Sci 1987;40:1319-1326.
59. Brainard GC, Watson-Whitmeyer M, Knobler RL, Lublin FD: Neuroendocrine regulation of immune paramters: Photoperiod control of the spleen in Syrian hamsters. Ann NY Acad Sci 1988; 540:704-706.
60. Aoyama H, Mori W, Mori N: Anti-glucocorticoid effects of melatonin in adult rats. Acta Pathol Jpn 1987;37:1143-1148.
61. Aoyama H, Mori W, Mori N: Anti-glucocorticoid effects of melatonin in young rats. Acta Pathol Jpn 1986;36:423-428.
62. Persengiev S, Patchev V, Velev B: Melatonin effects on thymus steroid receptors in the course of primary antibody responses: Significance of circulating glucocorticoid levels. Int J Biochem 1991; 23:1487-1489.
63. Persengiev S, Patchev V, Velev B: Steroid hormone receptors in the thymus: A site of immunomodulatory action of melatonin. Int J Biochem 1991;23:1483-1485.
64. 125I]iodomelationin binding sites in the duck thymus. Eur J Endocrinol 1994;130:320-324.
65. Pierpaoli W, Yi C: The involvement of pineal gland and melatonin in immunity and aging: Thymus mediated immunoreconstituting and antiviral activity of thyrotropin-releasing hormone. J Neuroimmunol 1990;27:99-109.
66. Pang SF, Yuan H, Yu ZH, Wang XL, Tang PL, Yau M: Melatonin binding sites in the nervous and immune systems; in Fraschini F, Reiter RJ (eds): Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. New York, Plenum, 1991, pp 107-116.
67. 125I]Iodomelatonin binding sites in spleens of birds and mammals. Neurosci Lett 1991;125:175-178.
68. Poon AMS, Liu ZM, Pang CS, Brown GM, Pang SF: Evidence for a direct action of melatonin on the immune system. Biol Signals 1994;3:107-117.
69. Niles LP: High affinity binding sites for melatonin in hamster spleen. Med Sci Res 1989;17:179-180.
70. 125I]Iodomelationin binding sites in spleens of guinea pigs. Life Sci 1992;50: 1719-1726.
71. 125I]iodomelationin by spleen membrane preparations of chicken. J Pineal Res 1992;12:167-173.
72. 125I]labelled iodomelatonin in the duck thymus. Biol Signals 1992;1: 208-217.
73. 125I]Labelled iodomelationin binding sites in the duck bursa of Fabricius: Binding characteristics and diurnal variation. Neurosci Lett 1992;146:163-166.
74. 125I]Iodomelatonin-binding sites in the bursa of Fabricius of birds: Binding characteristics, subcellular distribution, diurnal variations and age studies. J Endocrinol 1993;138: 51-57.
75. 125I] iodomelatonin binding sites in the pigeon spleen and modulation of binding by guanine nucleotides. J Pineal Res 1993;14:169-177.
76. 125I]iodomelatonin by partially purified membranes of rat thymus. J Neuroimmunol 1993; 45:121-126.
77. 125I]iodomelatonin by rat splenocytes: Characterization and its role on regulation of cyclic AMP production. J Neuroimmunol 1995;57:171-178.
78. Lopez-Gonzalez MA, Calvo JR, Osuna C, Rubio A, Guerrero JM: Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP. J Pineal Res 1992;12:97-104.
79. Lopez-Gonzalez MA, Calvo JR, Osuna C, Rubio A, Guerrero JM: Synergistic action of melatonin and vasoactive intestinal peptide in stimulating cyclic AMP production in human lymphocytes. J Pineal Res 1992;12:174-180.
80. Lopez-Gonzalez MA, Calvo JR, Sequra JJ, Guerrero JM: Characterization of melatonin binding sites in human peripheral blood neutrophils. Biotechnol Ther 1993;4:253-262.
81. Bendich A: Physiological role of antioxidants in the immune system. J Dairy Sci 1993;76:2789-2794.
82. Reiter RJ: Interactions of the pineal hormone melatonin with oxygen-centered free radicals: A brief review. Braz J Med Biol Res 1993;26:1141-1155.
83. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna Castroviejo D: A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11.
84. Vijayalaxmi, Reiter RJ, Sewerynek E, Poeggeler B, Leal BZ, Meltz ML: Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin. Radiation Res 1995;143:102-106.
85. Vijayalaxmi, Reiter RJ, Meltz ML: Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mut Res 1995;346:23-31.
86. Abe M, Reiter RJ, Orhii PB, Hara M, Poeggeler B: Inhibitory effect of melatonin on cataract formation in newborn rats. Evidence for an antioxidative role for melatonin. J Pineal Res 1994;17:94-100.
87. Melchiorri D, Reiter RJ, Attia AM, Hara M, Burgos A, Nistico G: Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci 1994;56:83-89.
88. Vacas MI, Cardinali DP: Diurnal changes in melatonin binding sites of hamster and rat brains: Correlation with neuroendocrine responsiveness to melatonin. Neurosci Lett 1979;15:259-263.
89. Zisapel N, Laudon M, Nir I: Melatonin receptors in discrete brain regions of the male rat: Age-associated decrease in receptor density and in circadian rhythmicity; in Reiter RJ, Pang SF (eds): Advances in Pineal Research. London, Libbey, 1989, vol 3, pp 189-194.
90. Laitinen JT, Castren E, Vakkuri O, Saavedra JM: Diurnal rhythm of melatonin binding in the rat suprachiasmatic nucleus. Endocrinology 1989;124:1585-1587.
91. 125I]Iodomelatonin binding sites in membrane preparations of quail brain: Characteristics and diurnal variations. Acta Endocrinol 1990;122:633-639.
92. 125I]Iodomelatonin binding sites in the pigeon brain: Binding characteristics, regional distribution and diurnal variation. J Endocrinol 1991;128:475-482.
93. 125I]Iodomelatonin binding sites in the chicken brain: Diurnal variation and effects of melatonin injection or pinealectomy. Biol Signals 1992;1:208-218.
94. Lee PPN, Pang SF: Identification and characterization of melatonin binding sites in the gastrointestinal tract of ducks. Life Sci 1992;50:117-125.
95. 125I] iodomelatonin binding sites in the male guinea pig kidney. J Pineal Res 1993;15:152-160.
96. 125I]iodomelatonin-binding sites in quail testes at mid-light and mid-dark. Neurosci Lett 1992;146:195-198.
97. Pang SF, Lee PPN, Chan YS, Ayre EA: Melatonin secretion and its rhythms in biological fluids; in Yu HS, Reiter RJ (eds): Melatonin: Biosynthesis, Physiological Effects and Clinical Applications. Boca Raton, CRC Press, 1992, pp 129-153.
98. Calvo JR, Rafii-El-Irdrissi M, Pozo D, Guerrero JM: Immunomodulatory role of melatonin: specific binding sites in human and rodent lymphoid cells. J Pineal Res 1995;18:119-126.
99. 125I]iodomelatonin by rat thymus membranes during postnatal development. Immunol Lett 1993;36: 59-64.
100. 125I] iodomelatonin binding sites in the chicken (Gallus domesticus) kidney and spleen. Cand J Physiol Pharm 1995;73:685-692.
101. Maestroni GJM, Pierpaoli W: Pharmacological control of the hormonally mediated immune response; in Ader R (ed): Psychoneuroimmunology. New York, Academic Press, 1981 pp 405-428.
102. Minton JE, Reddy PG, Blecha F: Removal of nocturnal secretion of melatonin fails to reduce antibody synthesis and interleukin-2 production of lambs. J Anim Sci 1991;69:565-570.
103. 125I]iodomelatonin binding sites in the guinea pig spleen. Neurosci Lett 1992;146:41-44.
104. 125I]iodomelatonin binding sites in the guinea pig spleen by melatonin injection is dependent on the dose and period but not the time. Life Sci 1994;54:1441-1448.
105. Carlson LL, Weaver DR, Reppert SM: Melatonin signal transduction in hamster brain: Inhibition of adenylyl cyclase by a pertussis toxin-sensitive G-protein. Endocrinology 1989;125:2670-2676.
106. Rivkees SA, Carlson L, Reppert SM: Guanine nucleotide-binding protein reuglation of melatonin receptor in lizard brain. Proc Natl Acad Sci USA 1989;86:3882-3886.
107. Morgan PJ, Lawson W, Davidson G, Edward Howell H: Guanine nucleotides regulate the affinity of melatonin receptors on the ovine pars tuberalis. Neuroendocrinology 1989;50:359-362.
108. Laitinen JT, Flugge G, Saavedra JM: Characterization of melatonin receptors in the rat area postrema: Modulation of affinity with cations and guanine nucleotides. Neuroendocrinol 1990;51:619-624.
109. Laitinen JT, Saavedra JM: Characterization of melatonin receptors in suprachiasmatic nuclei: Modulation of affinity with cations and guanine nucleotides. Endocrinology 1990;126:2110-2115.
110. Laitinen JT, Savedra JM: The chick retinal melatonin receptor revisited: Localization and modulation of agonist binding with guanine nucleotides. Brain Res 1990;528:349-352.
111. 125I]iodomelatonin binding to picomolar-affinity site in the Syrian hamster hypothalamus. Eur J Pharm 1990;189:95-98.
112. 125I]iodomelatonin in chick brain retain sensitivity to guanine nucleotides. Neurochemistry 1991;50:580-586.
113. 125I] iodomelatonin binding sites in chick retinal pigment epithelium but not in neuronal retina. J Neurochem 1991;57:685-689.
114. Stankov B, Fraschini F, Reiter RJ: Melatonin binding sites in the central nervous system. Brain Res Rev 1991;16:245-256.
115. Gauer F, Masson-Pevet M, Pevet P: Effect of constant light, pinealectomy and guanosine triphosphate gamma-S on the density of melatonin receptors in the rat suprachiasmatic nucleus: A possible implication on melatonin action. J Neuroendocrinol 1992;4:455-459.
116. 125I]iodomelatonin binding in the guinea pig spleen by guanine nucleotides and cations. Neuroendocrinology 1994;59:156-162.
117. 125I]iodomelationin binding sites in the chicken bursa of Fabricius and spleen. Neurosci Lett 1994;173:167-171.
118. 125I] iodomelatonin binding in the chicken lung, brain and kidney: The hypothesis of different subtypes of high affinity melatonin receptors. Biol Signals 1993;2:27-36.
119. Vanecek J, Vollrath L: Melatonin inhibits cyclic AMP and cyclic GMP accumlation in the rat pituitary. Brain Res 1989;505:157-159.
120. Conti A, Maestroni GJM: The clinical neuroimmunotherapeutic role of melatonin in oncology. J Pineal Res 1995;19:103-110.
121. Lissoni P, Barni S, Crispino S, Tancini G, Fraschini F: Endocrine and immune effects of melatonin therapy in metastatic cancer patients. Eur J Cancer Clin Oncol 1989;25:789-795.