Pha-739358: A pan-aurora kinase inhibitor

Haematologica Meeting Reports

Volumn 2, Issue 5, 2008, Pages 92-93

  Paquette, R ^a   Shah, N ^b   Sawyers, C ^c   Martinelli, G ^d   Nicoll, J ^a   Chalukya, M ^a   Locatelli, G ^e   Capolongo, L ^e   Moll, J ^e   Comis, S ^e   Laffranchi, B ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e NERVIANO MEDICAL SCIENCES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; AURORA KINASE INHIBITOR; BCR ABL PROTEIN; CRK LIKE PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; IMATINIB; PARACETAMOL; PHA 739358; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER RELAPSE; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CONFERENCE PAPER; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG INHIBITION; DRUG SAFETY; DRUG TOLERABILITY; ENDOREDUPLICATION; ENZYME INHIBITION; HUMAN; HYPERBILIRUBINEMIA; INJECTION SITE REACTION; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; PHENOTYPE; PREMEDICATION; PROTEIN PHOSPHORYLATION; TREATMENT RESPONSE;

EID: 54249112242     PISSN: 19707339     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (3)

1. Carpinelli P, et al. PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer. Mol Cancer Ther 2007;6:3158-68.
2. Modugno M, et al. Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358. Cancer Res 2007;67:7987-90.
3. Paquette R, et al. PHA-739358, an Aurora Kinase Inhibitor, Induces Clinical Responses in Chronic Myeloid Leukemia Harboring T315I Mutations of BCR-ABL. Blood (ASH Annual Meeting Abstracts), Nov 2007;110:1030.