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Volumn 198, Issue 9, 2008, Pages 1255-1257

Human genetics and malaria: Relevance for the design of clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON RECEPTOR; ANTIMALARIAL AGENT; BETA GLOBIN; CD31 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; ERYTHROCYTE BAND 3 PROTEIN; FANSIDAR; FC RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTAMINE; GLYCOPHORIN C; HEMOGLOBIN S; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MALARIA VACCINE; NITRIC OXIDE SYNTHASE; PROGUANIL; TUMOR NECROSIS FACTOR; VALINE;

EID: 54249099940     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/592223     Document Type: Editorial
Times cited : (6)

References (49)
  • 1
    • 0037167852 scopus 로고    scopus 로고
    • Detecting recent positive selection in the human genome from haplotype structure
    • Sabeti PC, Reich DE, Higgins JM, et al. Detecting recent positive selection in the human genome from haplotype structure. Nature 2002; 419:832-7.
    • (2002) Nature , vol.419 , pp. 832-837
    • Sabeti, P.C.1    Reich, D.E.2    Higgins, J.M.3
  • 2
    • 0035919696 scopus 로고    scopus 로고
    • Haplotype diversity and linkage disequilibrium at human G6PD: Recent origin of alleles that confer malarial resistance
    • Tishkoff SA, Varkonyi R, Cahinhinan N, et al. Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. Science 2001; 293:455-62.
    • (2001) Science , vol.293 , pp. 455-462
    • Tishkoff, S.A.1    Varkonyi, R.2    Cahinhinan, N.3
  • 3
    • 1842486672 scopus 로고    scopus 로고
    • The origin of malaria: Mixed messages from genetic diversity
    • Hartl DL. The origin of malaria: mixed messages from genetic diversity. Nat Rev Microbiol 2004; 2:15-22.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 15-22
    • Hartl, D.L.1
  • 4
    • 15044338866 scopus 로고    scopus 로고
    • The global distribution of clinical episodes of Plasmodium falciparum malaria
    • Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005; 434:214-7.
    • (2005) Nature , vol.434 , pp. 214-217
    • Snow, R.W.1    Guerra, C.A.2    Noor, A.M.3    Myint, H.Y.4    Hay, S.I.5
  • 5
    • 0002448869 scopus 로고
    • Disease and evolution
    • Haldane JBS. Disease and evolution. Ric Sci 1949; 19:68-76.
    • (1949) Ric Sci , vol.19 , pp. 68-76
    • Haldane, J.B.S.1
  • 6
    • 77049164783 scopus 로고
    • Protection afforded by sickle-cell trait against subtertian malarial infection
    • Allison AC. Protection afforded by sickle-cell trait against subtertian malarial infection. Br Med J 1954; 4857:290-4.
    • (1954) Br Med J , vol.4857 , pp. 290-294
    • Allison, A.C.1
  • 7
    • 0025913521 scopus 로고
    • Common west African HLA antigens are associated with protection from severe malaria
    • Hill AV, Allsopp CE, Kwiatkowski D, et al. Common west African HLA antigens are associated with protection from severe malaria. Nature 1991; 352:595-600.
    • (1991) Nature , vol.352 , pp. 595-600
    • Hill, A.V.1    Allsopp, C.E.2    Kwiatkowski, D.3
  • 8
    • 0037070775 scopus 로고    scopus 로고
    • Protective effects of the sickle cell gene against malaria morbidity and mortality
    • Aidoo M, Terlouw DJ, Kolczak MS, et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet 2002; 359:1311-2.
    • (2002) Lancet , vol.359 , pp. 1311-1312
    • Aidoo, M.1    Terlouw, D.J.2    Kolczak, M.S.3
  • 9
    • 20844435977 scopus 로고    scopus 로고
    • Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases
    • Williams TN, Mwangi TW, Wambua S, et al. Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases. J Infect Dis 2005; 192:178-86.
    • (2005) J Infect Dis , vol.192 , pp. 178-186
    • Williams, T.N.1    Mwangi, T.W.2    Wambua, S.3
  • 10
    • 34249679269 scopus 로고    scopus 로고
    • Hemoglobin variants and disease manifestations in severe falciparum malaria
    • May J, Evans JA, Timmann C, et al. Hemoglobin variants and disease manifestations in severe falciparum malaria. JAMA 2007; 297: 2220-6.
    • (2007) JAMA , vol.297 , pp. 2220-2226
    • May, J.1    Evans, J.A.2    Timmann, C.3
  • 11
    • 0004938385 scopus 로고
    • Erythrocytic mechanism of sickle cell resistance to malaria
    • Friedman MJ. Erythrocytic mechanism of sickle cell resistance to malaria. Proc Assoc Am Physicians 1978; 75:1994-7.
    • (1978) Proc Assoc Am Physicians , vol.75 , pp. 1994-1997
    • Friedman, M.J.1
  • 12
    • 0018138792 scopus 로고
    • Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria
    • Pasvol G, Weatherall DJ, Wilson RJ. Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria. Nature 1978; 274:701-3.
    • (1978) Nature , vol.274 , pp. 701-703
    • Pasvol, G.1    Weatherall, D.J.2    Wilson, R.J.3
  • 13
    • 38949087305 scopus 로고    scopus 로고
    • Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin
    • Cholera R, Brittain NJ, Gillrie MR, et al. Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin. Proc Natl Acad Sci U S A 2008; 105:991-6.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 991-996
    • Cholera, R.1    Brittain, N.J.2    Gillrie, M.R.3
  • 14
    • 54249152284 scopus 로고    scopus 로고
    • Crompton P, Traore B, Kayentao K, et al. Sickle cell trait is associated with delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria. J Infect Dis 2008; 198:1265-75 (in this issue).
    • Crompton P, Traore B, Kayentao K, et al. Sickle cell trait is associated with delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria. J Infect Dis 2008; 198:1265-75 (in this issue).
  • 15
    • 34249107535 scopus 로고    scopus 로고
    • Measurement of malaria vaccine efficacy in phase III trials: Report of a WHO consultation
    • Moorthy V, Reed Z, Smith PG. Measurement of malaria vaccine efficacy in phase III trials: report of a WHO consultation. Vaccine 2007; 25:5115-23.
    • (2007) Vaccine , vol.25 , pp. 5115-5123
    • Moorthy, V.1    Reed, Z.2    Smith, P.G.3
  • 16
    • 27644566200 scopus 로고    scopus 로고
    • Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell trait
    • Williams TN, Mwangi TW, Wambua S, et al. Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell trait. Nat Genet 2005; 37:1253-7.
    • (2005) Nat Genet , vol.37 , pp. 1253-1257
    • Williams, T.N.1    Mwangi, T.W.2    Wambua, S.3
  • 17
    • 0036605901 scopus 로고    scopus 로고
    • IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria
    • Koch O, Awomoyi A, Usen S, et al. IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. J Infect Dis 2002; 185:1684-7.
    • (2002) J Infect Dis , vol.185 , pp. 1684-1687
    • Koch, O.1    Awomoyi, A.2    Usen, S.3
  • 18
    • 19044393055 scopus 로고    scopus 로고
    • A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production
    • Morahan G, Boutlis CS, Huang D, et al. A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes Immun 2002; 3:414-8.
    • (2002) Genes Immun , vol.3 , pp. 414-418
    • Morahan, G.1    Boutlis, C.S.2    Huang, D.3
  • 19
    • 10744232364 scopus 로고    scopus 로고
    • IL4-589C/T polymorphism and IgE levels in severe malaria
    • Verra F, Luoni G, Calissano C, et al. IL4-589C/T polymorphism and IgE levels in severe malaria. Acta Trop 2004; 90:205-9.
    • (2004) Acta Trop , vol.90 , pp. 205-209
    • Verra, F.1    Luoni, G.2    Calissano, C.3
  • 20
    • 1342346046 scopus 로고    scopus 로고
    • Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study
    • Walley AJ, Aucan C, Kwiatkowski D, Hill AV. Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study. Eur J Hum Genet 2004; 12:132-8.
    • (2004) Eur J Hum Genet , vol.12 , pp. 132-138
    • Walley, A.J.1    Aucan, C.2    Kwiatkowski, D.3    Hill, A.V.4
  • 21
    • 22544458241 scopus 로고    scopus 로고
    • Analysis of IL10 haplotypic associations with severe malaria
    • Wilson JN, Rockett K, Jallow M, et al. Analysis of IL10 haplotypic associations with severe malaria. Genes Immun 2005; 6:462-6.
    • (2005) Genes Immun , vol.6 , pp. 462-466
    • Wilson, J.N.1    Rockett, K.2    Jallow, M.3
  • 22
    • 45049084554 scopus 로고    scopus 로고
    • A functional promoter variant in IL12B predisposes to cerebral malaria
    • Marquet S, Doumbo O, Cabantous S, et al. A functional promoter variant in IL12B predisposes to cerebral malaria. Hum Mol Genet 2008 7:2190-5.
    • (2008) Hum Mol Genet , vol.7 , pp. 2190-2195
    • Marquet, S.1    Doumbo, O.2    Cabantous, S.3
  • 23
    • 0036692110 scopus 로고    scopus 로고
    • CD40L association with protection from severe malaria
    • Sabeti P, Usen S, Farhadian S, et al. CD40L association with protection from severe malaria. Genes Immun 2002; 3:286-91.
    • (2002) Genes Immun , vol.3 , pp. 286-291
    • Sabeti, P.1    Usen, S.2    Farhadian, S.3
  • 24
    • 0035399821 scopus 로고    scopus 로고
    • Fcγ Receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection VII. Asembo Bay Cohort Project
    • Shi YP, Nahlen BL, Kariuki S, et al. Fcγ Receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection VII. Asembo Bay Cohort Project. Journal Infect Dis 2001; 184:107-11.
    • (2001) Journal Infect Dis , vol.184 , pp. 107-111
    • Shi, Y.P.1    Nahlen, B.L.2    Kariuki, S.3
  • 25
    • 0028169333 scopus 로고
    • Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria
    • McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria. Nature 1994; 371:508-10.
    • (1994) Nature , vol.371 , pp. 508-510
    • McGuire, W.1    Hill, A.V.2    Allsopp, C.E.3    Greenwood, B.M.4    Kwiatkowski, D.5
  • 26
    • 0001153209 scopus 로고    scopus 로고
    • Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria
    • Kun JF, Mordmuller B, Lell B, Lehman LG, Luckner D, Kremsner PG. Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet 1998; 351:265-6.
    • (1998) Lancet , vol.351 , pp. 265-266
    • Kun, J.F.1    Mordmuller, B.2    Lell, B.3    Lehman, L.G.4    Luckner, D.5    Kremsner, P.G.6
  • 27
    • 21344433481 scopus 로고    scopus 로고
    • Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region
    • Koch O, Rockett K, Jallow M, Pinder M, Sisay-Joof F, Kwiatkowski D. Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. Genes Immun 2005; 6:312-8.
    • (2005) Genes Immun , vol.6 , pp. 312-318
    • Koch, O.1    Rockett, K.2    Jallow, M.3    Pinder, M.4    Sisay-Joof, F.5    Kwiatkowski, D.6
  • 28
    • 1342319661 scopus 로고    scopus 로고
    • Interferon-α receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia
    • Aucan C, Walley AJ, Hennig BJ, et al. Interferon-α receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. Genes Immun 2003; 4:275-82.
    • (2003) Genes Immun , vol.4 , pp. 275-282
    • Aucan, C.1    Walley, A.J.2    Hennig, B.J.3
  • 29
    • 48749127715 scopus 로고    scopus 로고
    • Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda
    • Clark TD, Greenhouse B, Njama-Meya D, et al. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis 2008; 198:393-400.
    • (2008) J Infect Dis , vol.198 , pp. 393-400
    • Clark, T.D.1    Greenhouse, B.2    Njama-Meya, D.3
  • 30
    • 0032899564 scopus 로고    scopus 로고
    • The role of red blood cell polymorphisms in resistance and susceptibility to malaria
    • Lell B, May J, Schmidt-Ott RJ, et al. The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin Infect Dis 1999; 28:794-9.
    • (1999) Clin Infect Dis , vol.28 , pp. 794-799
    • Lell, B.1    May, J.2    Schmidt-Ott, R.J.3
  • 31
    • 0034304855 scopus 로고    scopus 로고
    • Human genetic factors related to susceptibility to mild malaria in Gabon
    • Migot-Nabias F, Mombo LE, Luty AJ, et al. Human genetic factors related to susceptibility to mild malaria in Gabon. Genes Immun 2000; 1:435-41.
    • (2000) Genes Immun , vol.1 , pp. 435-441
    • Migot-Nabias, F.1    Mombo, L.E.2    Luty, A.J.3
  • 32
    • 11344284113 scopus 로고    scopus 로고
    • Host polymorphisms and the incidence of malaria in Ugandan children
    • Parikh S, Dorsey G, Rosenthal PJ. Host polymorphisms and the incidence of malaria in Ugandan children. Am J Trop Med Hyg 2004; 71:750-3.
    • (2004) Am J Trop Med Hyg , vol.71 , pp. 750-753
    • Parikh, S.1    Dorsey, G.2    Rosenthal, P.J.3
  • 33
    • 33744459954 scopus 로고    scopus 로고
    • The effect of α+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya
    • Wambua S, Mwangi TW, Kortok M, et al. The effect of α+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya. PLoS Med 2006; 3:e158.
    • (2006) PLoS Med , vol.3
    • Wambua, S.1    Mwangi, T.W.2    Kortok, M.3
  • 34
    • 0029858255 scopus 로고    scopus 로고
    • High incidence of malaria in α-thalassemic children
    • Williams TN, Maitland K, Bennett S, et al. High incidence of malaria in α-thalassemic children. Nature 1996; 383:522-5.
    • (1996) Nature , vol.383 , pp. 522-525
    • Williams, T.N.1    Maitland, K.2    Bennett, S.3
  • 35
    • 22544450545 scopus 로고    scopus 로고
    • TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso
    • Flori L, Delahaye NF, Iraqi FA, Hernandez-Valladares M, Fumoux F, Rihet P. TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso. Genes Immun 2005; 6:472-80.
    • (2005) Genes Immun , vol.6 , pp. 472-480
    • Flori, L.1    Delahaye, N.F.2    Iraqi, F.A.3    Hernandez-Valladares, M.4    Fumoux, F.5    Rihet, P.6
  • 36
    • 0032758650 scopus 로고    scopus 로고
    • Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria
    • Levesque MC, Hobbs MR, Anstey NM, et al. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J Infect Dis 1999; 180:1994-2002.
    • (1999) J Infect Dis , vol.180 , pp. 1994
    • Levesque, M.C.1    Hobbs, M.R.2    Anstey, N.M.3
  • 37
    • 33750605005 scopus 로고    scopus 로고
    • Placental malaria in women with South-East Asian ovalocytosis
    • Benet A, Khong TY, Ura A, et al. Placental malaria in women with South-East Asian ovalocytosis. Am J Trop Med Hyg 2006; 75: 597-604.
    • (2006) Am J Trop Med Hyg , vol.75 , pp. 597-604
    • Benet, A.1    Khong, T.Y.2    Ura, A.3
  • 39
    • 33746162770 scopus 로고    scopus 로고
    • Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy
    • Mockenhaupt FP, Hamann L, von Gaertner C, et al. Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. J Infect Dis 2006; 194:184-8.
    • (2006) J Infect Dis , vol.194 , pp. 184-188
    • Mockenhaupt, F.P.1    Hamann, L.2    von Gaertner, C.3
  • 40
    • 0032782389 scopus 로고    scopus 로고
    • Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations
    • Kaneko A, Bergqvist Y, Taleo G, Kobayakawa T, Ishizaki T, Bjorkman A. Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations. Pharmacogenetics 1999; 9:317-26.
    • (1999) Pharmacogenetics , vol.9 , pp. 317-326
    • Kaneko, A.1    Bergqvist, Y.2    Taleo, G.3    Kobayakawa, T.4    Ishizaki, T.5    Bjorkman, A.6
  • 41
    • 0029960882 scopus 로고    scopus 로고
    • Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians
    • Skjelbo E, Mutabingwa TK, Bygbjerg I, Nielsen KK, Gram LF, Broosen K. Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians. Clin Pharmacol Ther 1996; 59:304-11.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 304-311
    • Skjelbo, E.1    Mutabingwa, T.K.2    Bygbjerg, I.3    Nielsen, K.K.4    Gram, L.F.5    Broosen, K.6
  • 42
    • 0030975288 scopus 로고    scopus 로고
    • High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu
    • Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T. High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu. Lancet 1997; 349:921-2.
    • (1997) Lancet , vol.349 , pp. 921-922
    • Kaneko, A.1    Kaneko, O.2    Taleo, G.3    Bjorkman, A.4    Kobayakawa, T.5
  • 43
    • 34447569316 scopus 로고    scopus 로고
    • Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: Implications for malaria treatment in Africa
    • Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther 2007; 82:197-203.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 197-203
    • Parikh, S.1    Ouedraogo, J.B.2    Goldstein, J.A.3    Rosenthal, P.J.4    Kroetz, D.L.5
  • 44
  • 45
    • 42549137072 scopus 로고    scopus 로고
    • Pyruvate kinase deficiency and malaria
    • Ayi K, Min-Oo G, Serghides L, et al. Pyruvate kinase deficiency and malaria. N Engl J Med 2008; 358:1805-10.
    • (2008) N Engl J Med , vol.358 , pp. 1805-1810
    • Ayi, K.1    Min-Oo, G.2    Serghides, L.3
  • 47
    • 0034055892 scopus 로고    scopus 로고
    • Host factors affecting the delay of reappearance of Plasmodium falciparum after radical treatment among a semi-immune population exposed to intense perennial transmission
    • Sokhna CS, Rogier C, Dieye A, Trape JF. Host factors affecting the delay of reappearance of Plasmodium falciparum after radical treatment among a semi-immune population exposed to intense perennial transmission. Am J Trop Med Hyg 2000; 62:266-70.
    • (2000) Am J Trop Med Hyg , vol.62 , pp. 266-270
    • Sokhna, C.S.1    Rogier, C.2    Dieye, A.3    Trape, J.F.4
  • 49
    • 0036891350 scopus 로고    scopus 로고
    • Increased efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria among children with sickle cell trait in Western Kenya
    • Terlouw DJ, Aidoo MA, Udhayakumar V, et al. Increased efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria among children with sickle cell trait in Western Kenya. J Infect Dis 2002; 186:1661-8.
    • (2002) J Infect Dis , vol.186 , pp. 1661-1668
    • Terlouw, D.J.1    Aidoo, M.A.2    Udhayakumar, V.3


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