Helical peptides derived from lactoferrin bind hepatitis C virus envelope protein E2

Chemical Biology and Drug Design

Volumn 72, Issue 5, 2008, Pages 436-443

  Beleid, Reem ^a   Douglas, Donna ^a   Kneteman, Norman ^a   Kaur, Kamaljit ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Envelope protein E2; Hepatitis C virus; Lactoferrin derived peptides; Protein peptide interaction

Indexed keywords

BIOTIN; GLYCOPROTEIN E2; LACTOFERRIN; LACTOFERRIN DERIVED PEPTIDE; PEPTIDE; STREPTAVIDIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONTROLLED STUDY; EMBRYO CELL; GENOTYPE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; KIDNEY CELL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CELLS, CULTURED; HEPATOCYTES; HUMANS; LACTOFERRIN; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; VIRAL ENVELOPE PROTEINS;

HEPATITIS C VIRUS; HEPATITIS C VIRUS GENOTYPE 1;

EID: 54249087977     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00715.x     Document Type: Article

References (31)

1. Manns M.P., Foster G.R., Rockstroh J.K., Zeuzem S., Zoulim F., Houghton M. (2007) The way forward in HCV treatment - finding the right path. Nat Rev Drug Discov 6 : 991 1000.
2. Chevaliez S., Pawlotsky J.M. (2007) Hepatitis C virus: virology, diagnosis and management of antiviral therapy. World J Gastroenterol 13 : 2461 2466.
3. Manns M.P., Wedemeyer H., Cornberg M. (2006) Treating viral hepatitis C: efficacy, side effects, and complications. Gut 55 : 1350 1359.
4. Parfieniuk A., Jaroszewicz J., Flisiak R. (2007) Specifically targeted antiviral therapy for hepatitis C virus. World J Gastroenterol 13 : 5673 5681.
5. Flisiak R., Dumont J.M., Crabbe R. (2007) Cyclophilin inhibitors in hepatitis C viral infection. Expert Opin Investig Drugs 16 : 1345 1354.
6. Dimitrov D.S. (2004) Virus entry: molecular mechanisms and biomedical applications. Nat Rev Microbiol 2 : 109 122.
7. Meanwell N.A. (2006) Hepatitis C virus entry: an intriguing challenge for drug discovery. Curr Opin Investig Drugs 7 : 727 732.
8. Cocquerel L., Voisset C., Dubuisson J. (2006) Hepatitis C virus entry: potential receptors and their biological functions. J Gen Virol 87 : 1075 1084.
9. Cao J., Zhao P., Miao X.H., Zhao L.J., Xue L.J., Qi Zt Z. (2003) Phage display selection on whole cells yields a small peptide specific for HCV receptor human CD81. Cell Res 13 : 473 479.
10. VanCompernolle S.E., Wiznycia A.V., Rush J.R., Dhanasekaran M., Baures P.W., Todd S.C. (2003) Small molecule inhibition of hepatitis C virus E2 binding to CD81. Virology 314 : 371 380.
11. Wagner C.E., Mohler M.L., Kang G.S., Miller D.D., Geisert E.E., Chang Y.A., Fleischer E.B., Shea K.J. (2003) Synthesis of 1-boraadamantaneamine derivatives with selective astrocyte vs C6 glioma antiproliferative activity. A novel class of anti-hepatitis C agents with potential to bind CD81. J Med Chem 46 : 2823 2833.
12. Pecheur E.I., Lavillette D., Alcaras F., Molle J., Boriskin Y.S., Roberts M., Cosset F.L., Polyak S.J. (2007) Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Biochemistry 46 : 6050 6059.
13. Bertaux C., Daelemans D., Meertens L., Cormier E.G., Reinus J.F., Peumans W.J., Van Damme E.J., Igarashi Y., Oki T., Schols D., Dragic T., Balzarini J. (2007) Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions. Virology 366 : 40 50.
14. Helle F., Wychowski C., Vu-Dac N., Gustafson K.R., Voisset C., Dubuisson J. (2006) Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans. J Biol Chem 281 : 25177 25183.
15. Nozaki A., Ikeda M., Naganuma A., Nakamura T., Inudoh M., Tanaka K., Kato N. (2003) Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein. J Biol Chem 278 : 10162 10173.
16. Jameson G.B., Anderson B.F., Norris G.E., Thomas D.H., Baker E.N. (1998) Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change. Acta Crystallogr D Biol Crystallogr 54 : 1319 1335.
17. Yagnik A.T., Lahm A., Meola A., Roccasecca R.M., Ercole B.B., Nicosia A., Tramontano A. (2000) A model for the hepatitis C virus envelope glycoprotein E2. Protein Struct Funct Genet 40 : 355 366.
18. Kaur K., Andrew L.C., Wishart D.S., Vederas J.C. (2004) Dynamic relationships among type IIa bacteriocins: temperature effects on antimicrobial activity and on structure of the C-terminal amphipathic alpha helix as a receptor-binding region. Biochemistry 43 : 9009 9020.
19. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193 : 265 275.
20. Kuzmic P. (1996) Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. Anal Biochem 237 : 260 273.
21. Sreerama N., Woody R.W. (2000) Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. Anal Biochem 287 : 252 260.
22. Rosa D., Campagnoli S., Moretto C., Guenzi E., Cousens L., Chin M., Dong C., Weiner A.J., Lau J.Y., Choo Q.L., Chien D., Pileri P., Houghton M., Abrignani S. (1996) A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci USA 93 : 1759 1763.
23. Wakita T., Taya C., Katsume A., Kato J., Yonekawa H., Kanegae Y., Saito I., Hayashi Y., Koike M., Kohara M. (1998) Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system. J Biol Chem 273 : 9001 9006.
24. Kuzmic P., Hill C., Janc J.W. (2004) Practical robust fit of enzyme inhibition data. Methods Enzymol 383 : 366 381.
25. Kaur K., Lan M.J.K., Pratt R.F. (2001) Mechanism of inhibition of the class C beta-lactamase of Enterobacter cloacae P99 by cyclic acyl phosph(on)ates: rescue by return. J Am Chem Soc 123 : 10436 10443.
26. Eisenberg D., Weiss R.M., Terwilliger T.C. (1982) The helical hydrophobic moment: a measure of the amphiphilicity of a helix. Nature 299 : 371 374.
27. Carver T., Bleasby A. (2003) The design of Jemboss: a graphical user interface to EMBOSS. Bioinformatics 19 : 1837 1843.
28. Flint M., Maidens C., Loomis-Price L.D., Shotton C., Dubuisson J., Monk P., Higginbottom A., Levy S., McKeating J.A. (1999) Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J Virol 73 : 6235 6244.
29. Goffard A., Dubuisson J. (2003) Glycosylation of hepatitis C virus envelope proteins. Biochimie 85 : 295 301.
30. Abe K., Nozaki A., Tamura K., Ikeda M., Naka K., Dansako H., Hoshino H.O., Tanaka K., Kato N. (2007) Tandem repeats of lactoferrin-derived anti-hepatitis C virus peptide enhance antiviral activity in cultured human hepatocytes. Microbiol Immunol 51 : 117 125.
31. De Francesco R., Migliaccio G. (2005) Challenges and successes in developing new therapies for hepatitis C. Nature 436 : 953 960.