Quantitative evaluation of carotid plaque echogenicity by integrated backscatter analysis: Correlation with symptomatic history and histologic findings

Cerebrovascular Diseases

Volumn 26, Issue 6, 2008, Pages 578-583

  Nagano, Keiko ^a   Yamagami, Hiroshi ^a,c   Tsukamoto, Yoshitane ^b,d   Nagatsuka, Kazuyuki ^a   Yasaka, Masahiro ^a,e   Nagata, Izumi ^b,f   Hori, Masatsugu ^a   Kitagawa, Kazuo ^a   Naritomi, Hiroaki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

^e NATIONAL HOSPITAL ORGANIZATION   (Japan)

^f NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Carotid plaque echogenicity; Carotid stenosis; Integrated backscatter analysis; Ischemic stroke; Ultrasonography

Indexed keywords

ADULT; AGED; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY STENT; DENSITOMETRY; FEMALE; HISTOLOGY; HUMAN; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

AGED; AMAUROSIS FUGAX; ATHEROSCLEROSIS; BRAIN ISCHEMIA; CALCINOSIS; CALIBRATION; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; CAROTID ARTERY, INTERNAL; COMORBIDITY; DENSITOMETRY; DIFFUSION MAGNETIC RESONANCE IMAGING; ENDARTERECTOMY, CAROTID; FEMALE; HEMORRHAGE; HUMANS; ISCHEMIC ATTACK, TRANSIENT; LIPIDS; MALE; MIDDLE AGED; NECROSIS; RISK FACTORS; STENTS; ULTRASONOGRAPHY, DOPPLER, DUPLEX;

EID: 54149101149     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000165110     Document Type: Article

References (27)

1. Polak JF, Shemanski L, O'Leary DH, Lefkowitz D, Prince TR, Savage PJ, Brant WE, Reid C: Hypoechoic plaque at US of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Radiology 1998;208:649-654.
2. Mathiesen EB, Bønaa KH, Joakimsen O: Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the tromsø study. Circulation 2001;103:2171-2175.
3. Grønholdt ML, Nordestgaard BG, Schroeder TV, Vorstrup S, Sillesen H: Ultrasonic echolucent carotid plaques predict future strokes. Circulation 2001;104:68-73.
4. Hennerici M, Baezner H, Daffertshofer M: Ultrasound and arterial disease. Cerebrovasc Dis 2004;17(suppl 1):19-33.
5. Fisher M, Paganini-Hill A, Martin A, Cosgrove M, Toole JF, Barnett HJ, Norris J: Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis. Stroke 2005;36:253-257.
6. Bassiouny HS, Sakaguchi Y, Mikucki SA, McKinsey JF, Piano G, Gewertz BL, Glagov S: Juxtalumenal location of plaque necrosis and neoformation in symptomatic carotid stenosis. J Vasc Surg 1997;26:585-594.
7. Gray-Weale AC, Graham JC, Burnett JR, Byrne K, Lusby RJ: Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J Cardiovasc Surg (Torino) 1988;29:676-681.
8. Hatsukami TS, Ferguson MS, Beach KW, Gordon D, Detmer P, Burns D: Carotid plaque morphology and clinical events. Stroke 1997;28:95-100.
9. Carr S, Farb A, Pearce WH, Virmani R, Yao JS: Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. J Vasc Surg 1996;23:755-765.
10. Uwatoko T, Toyoda K, Inoue T, Yasumori K, Hirai Y, Makihara N, Fujimoto S, Ibayashi S, Iida M, Okada Y: Carotid artery calcification on multislice detector-row computed tomography. Cerebrovasc Dis 2007;24:20-26.
11. el-Barghouty N, Nicolaides A, Bahal V, Geroulakos G, Androulakis A: The identification of the high risk carotid plaque. Eur J Vasc Endovasc Surg 1996;11:470-478.
12. Sabetai MM, Tegos TJ, Nicolaides AN, Dhanjil S, Pare GJ, Stevens JM: Reproducibility of computer-quantified carotid plaque echogenicity. Can we overcome the subjectivity? Stroke 2000;31:2189-2196.
13. Lal BK, Hobson RW 2nd, Pappas PJ, Kubicka R, Hameed M, Chakhtoura EY, Jamil Z, Padberg FT Jr, Haser PB, Durán WN: Pixel distribution analysis of B-mode ultrasound scan images predicts histologic features of atherosclerotic carotid plaques. J Vasc Surg 2002;35:1210-1217.
14. Takiuchi S, Rakugi H, Honda K, Masuyama T, Hirata N, Ito H, Sugimoto K, Yanagitani Y, Moriguchi K, Okamura A, Higaki J, Ogihara T: Quantitative ultrasonic tissue characterization can identify high-risk atherosclerotic alteration in human carotid arteries. Circulation 2000;102:766-770.
15. Urbani MP, Picano E, Parenti G, Mazzarisi A, Fiori L, Paterni M, Pelosi G, Landini L: In vivo radiofrequency-based ultrasonic tissue characterization of the atherosclerotic plaque. Stroke 1993;24:1507-1512.
16. Waki H, Masuyama T, Mori H, Maeda T, Kitade K, Moriyasu K, Tsujimoto M, Fujimoto K, Koshimae N, Matsuura N: Ultrasonic tissue characterization of the atherosclerotic carotid artery histological correlates of carotid integrated backscatter. Circ J 2003;67:1013-1016.
17. Waters KR, Bridal SL, Cohen-Bacrie C, Levrier C, Fornès P, Laugier P: Parametric analysis of carotid plaque using a clinical ultrasound imaging system. Ultrasound Med Biol 2003;29:1521-1530.
18. Kawasaki M, Takatsu H, Noda T, Ito Y, Kunishima A, Arai M, Nishigaki K, Takemura G, Morita N, Minatoguchi S, Fujiwara H: Non-invasive quantitative tissue characterization and two-dimensional color-coded map of human atherosclerotic lesions using ultrasound integrated backscatter: comparison between histology and integrated backscatter images. J Am Coll Cardiol 2001;38:486-492.
19. Katakami N, Kaneto H, Matsuhisa M, Umayahara Y, Kosugi K, Yamasaki Y: Clustering of several cardiovascular risk factors affects tissue characteristics of the carotid artery. Atherosclerosis 2008;198:208-213.
20. Watanabe K, Sugiyama S, Kugiyama K, Honda O, Fukushima H, Koga H, Horibata Y, Hirai T, Sakamoto T, Yoshimura M, Yamashita Y, Ogawa H: Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease. J Am Coll Cardiol 2005;46:2022-2030.
21. Yamagami H, Kitagawa K, Nagai Y, Hougaku H, Sakaguchi M, Kuwabara K, Kondo K, Masuyama T, Matsumot M, Hori M: Higher levels of interleukin-6 are associated with lower echogenicity of carotid artery plaques. Stroke 2004;35:677-681.
22. Tegos TJ, Sohail M, Sabetai MM, Robless P, Akbar N, Pare G, Stansby G, Nicolaides AN: Echomorphologic and histopathologic characteristics of unstable carotid plaques. Am J Neuroradiol 2000;21:1937-1944.
23. Grønholdt MLM, Nordestgaard BG, Wiebe BM, Wilhjelm JE, Sillesen H: Echo-lucency of computerized ultrasound images of carotid atherosclerotic plaques are associated with increased levels of triglyceride-rich lipoproteins as well as increased plaque lipid content. Circulation 1998;97:34-40.
24. Sabetai MM, Tegos TJ, Nicolaides AN, El-Atrozy TS, Dhanjil S, Griffin M, Belcaro G, Geroulakos G: Hemispheric symptoms and carotid plaque echomorphology. J Vasc Surg 2000;31:39S-49S.
25. North American Symptomatic Carotid Endarterectomy Trial Collaborators: Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl Med 1991;325:445-453.
26. Kitagawa K, Hougaku H, Yamagami H, Hashimoto H, Itoh T, Shimizu Y, Takahashi D, Murata S, Seike Y, Kondo K, Hoshi T, Furukado S, Abe Y, Yagita Y, Sakaguchi M, Tagaya M, Etani H, Fukunaga R, Nagani Y, Matsumoto M, Hori M: Carotid intima-media thickness and risk of cardiovascular events in high-risk patients. Cerebrovasc Dis 2007;24:35-42.
27. Sztajzel R, Momjian S, Momjian-Mayor I, Murith N, Djebaili K, Boissard G, Comelli M, Pizolatto G: Stratified gray-scale median analysis and color mapping of the carotid plaque: correlation with endarterectomy specimen histology of 28 patients. Stroke 2005;36:741-745.