Manipulating myocyte cell cycle control for cardiac repair

Cardiovascular Research

Volumn 80, Issue 2, 2008, Pages 161-162

  Gorr, Thomas A ^a   Deten, Alexander ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; FIBROBLAST GROWTH FACTOR 1; GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE P38; RETINOBLASTOMA PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; TROPOMYOSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL CYCLE; CELL DIFFERENTIATION; CELL THERAPY; CYTOKINESIS; DNA SYNTHESIS; EDITORIAL; EMBRYONIC STEM CELL; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART WEIGHT; HEMATOPOIETIC STEM CELL; HUMAN; ISCHEMIC HEART DISEASE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STEM CELL TRANSPLANTATION; TRANSGENIC MOUSE; TREATMENT OUTCOME;

ADENOVIRIDAE; ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART DISEASES; HUMANS; MYOCARDIUM; REGENERATION; S-PHASE KINASE-ASSOCIATED PROTEINS; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 54149096992     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn241     Document Type: Editorial

References (21)

1. Davani S, Deschaseaux F, Chalmers D, Tiberghien P, Kantelip JP. Can stem cells mend a broken heart? Cardiovasc Res 2005;65:305-316.
2. Luttun A, Carmeliet P. De novo vasculogenesis in the heart. Cardiovasc Res 2003;58:378-389.
3. Brockes JP, Kumar A. Appendage regeneration in adult vertebrates and implications for regenerative medicine. Science 2005;310:1919- 1923.
4. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest 2005;115:572-583.
5. Anversa P, Leri A, Kajstura J, Nadal-Ginard B. Myocyte growth and cardiac repair. J Mol Cell Cardiol 2002;34:91-105.
6. Rubart M, Field LJ. Cardiac regeneration: repopulating the heart. Annu Rev Physiol 2006;68:29-49.
7. Capasso JM, Bruno S, Cheng W, Li P, Rodgers R, Darzynkiewicz Z et al. Ventricular loading is coupled with DNA synthesis in adult cardiac myocytes after acute and chronic myocardial infarction in rats. Circ Res 1992;71:1379-1389.
8. Ferrans VJ, Rodriguez ER. Evidence of myocyte hyperplasia in hypertrophic cardiomyopathy and other disorders with myocardial hypertrophy? Z Kardiol 1987;76(Suppl 31):20-25.
9. Nag AC, Healy CJ, Cheng M. DNA synthesis and mitosis in adult amphibian cardiac muscle cells in vitro. Science 1979;205:1281-1282.
10. Oberpriller JO, Oberpriller JC, Matz DG, Soonpaa MH. Stimulation of proliferative events in the adult amphibian cardiac myocyte. Ann N Y Acad Sci 1995;752:30-46.
11. Tamamori-Adachi M, Takagi H, Hashimoto K, Goto K, Hidaka T, Koshimizu U et al. Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. Cardiovasc Res 2008;80:181-190.
12. Tamamori-Adachi M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M et al. Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res 2003;92:e12-e19.
13. Pasumarthi KB, Nakajima H, Nakajima HO, Soonpaa MH, Field LJ. Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res 2005;96:110-118.
14. Hassink RJ, Pasumarthi KB, Nakajima H, Rubart M, Soonpaa MH, de la Riviere AB et al. Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res 2008;78:18- 25.
15. Angelis E, Garcia A, Chan SS, Schenke-Layland K, Ren SX, Goodfellow SJ et al. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Circ Res 2008;102:1222-1229.3
16. MacLellan WR, Garcia A, Oh H, Frenkel P, Jordan MC, Roos KP et al. Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of pp130 plus heart-specific deletion of Rb. Mol Cell Biol 2005;25:2486-2497.
17. Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 2005;19:1175-1187.
18. Engel FB, Hsieh PCH, Lee RT, Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci USA 2006;103: 15546-15551.
19. Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem 2004;279:35858-35866.
20. Cheng RK, Asai T, Tang HY, Dashoush NH, Kara RJ, Costa KD et al. Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure. Circ Res 2007;100:1741-1748.
21. Datwyler DA, Magyar JP, Weikert C, Wightman L, Wagner E, Eppenberger HM. Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes. Cells Tissues Organs 2003;175:61-71.