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2 to afford the corresponding aldol product with high purity.
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2 to afford the corresponding aldol product with high purity.
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Spectroscopic Data for Products All products are known compounds; see refs. 7d,e and 8a,1. 4-Hydroxy-4-phenylbutan-2-one (2a) 1H NMR (300 MHz, CDCl3, δ, 7.36-7.27 (m, 4 H, 5.15 (dd, J1, 3.6 Hz, J2, 8.7 Hz, 1 H, 2.88-2.83 (m, 3 H, 2.19 (s, 3 H, 4-(4-Fluorophenyl)-4-hydroxybutan-2-one(2b) 1H NMR (300 MHz, CDCl3, δ, 8.04 (d, J, 8.1 Hz, 2 H, 7.03 (t, J, 8.7 Hz, 2 H, 5.13 (t, J, 3.6 Hz, 1 H, 2.83 (d, J, 7.5 Hz, 2 H, 2.20 (s, 3 H, 4-(4-Chlorophenyl)-4- hydroxybutan-2-one (2c) 1H NMR (300 MHz, CDCl3, δ, 7.32 (t, J, 4.2 Hz, 2 H, 7.46 (d, J, 8.1 Hz, 2 H, 5.14 (t, J, 4.8 Hz, 1 H, 3.38 (d, J, 1.5 Hz, 1 H, 2.85, 2.81 (m, 2 H, 2.19 (s, 3 H, 4-(4-Bromophenyl)-4-hydroxybutan-2-one (2d) 1H NMR (300 MHz, CDCl3, δ, 7.47 d, J
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2 = 8.7 Hz, 4 H), 7.52 (d, J = 8.7 Hz, 4 H), 4.99 (d, J = 7.5 Hz, 1 H), 4.24-4.21 (m, 2 H), 3.87-3.73 (m, 8 H), 3.49-3.46 (m, 1 H), 2.97-2.91 (m, 3 H), 2.57-2.55 (m, 3 H), 2.51-2.45 (m, 3 H).
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