The reported germline repertoire of human immunoglobulin kappa chain genes is relatively complete and accurate

Immunogenetics

Volumn 60, Issue 11, 2008, Pages 669-676

  Collins, Andrew M ^a   Wang, Yan ^a   Singh, Viveka ^a   Yu, Phillip ^a   Jackson, Katherine J ^a   Sewell, William A ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

Allelic variants; IGKV; Immunoglobulin; Light chain; Sequencing errors; Somatic point mutation

Indexed keywords

EXONUCLEASE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; NUCLEOTIDE;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; DNA MODIFICATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOMICS; HUMAN; HUMORAL IMMUNITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; DNA, COMPLEMENTARY; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; POLYMORPHISM, GENETIC; SEQUENCE ALIGNMENT;

EID: 54049158422     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-008-0325-z     Document Type: Article

References (22)

1. MJ Atkinson MJ Cowan AJ Feeney 1996 New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism Immunogenetics 44 115 120
2. V Barbie MP Lefranc 1998 The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments Exp Clin Immunogenet 15 171 183
3. JPL Cox IM Tomlinson G Winter 1994 A directory of human germ-line Vk segments reveals a strong bias in their usage Eur J Immunol 24 827 836
4. I Dahlke DJ Nott J Ruhno WA Sewell AM Collins 2006 Antigen selection in the IgE response of allergic and non-allergic individuals J Allergy Clin Immunol 117 1477 1483
5. NL Farner T Dorner PE Lipsky 1999 Molecular mechanisms and selection influence the generation of the human V lambda J lambda repertoire J Immunol 162 2137 2145
6. AJ Feeney MJ Atkinson MJ Cowan G Escuro G Lugo 1996 A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease J Clin Invest 97 2277 2282
7. V Giudicelli D Chaume MP Lefranc 2004 IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis Nucleic Acids Res 32 W435 W440
8. O Gotoh 1982 An improved algorithm for matching biological sequences J Mol Biol 162 705 708
9. KJ Jackson B Gaeta AM Collins 2007 Identifying highly mutated IGHD genes in the junctions of rearranged human immunoglobulin heavy chain genes J Immunol Methods 324 26 37
10. C Kanz P Aldebert N Althorpe W Baker A Baldwin K Bates P Browne A van den Broek M Castro G Cochrane K Duggan R Eberhardt N Faruque J Gamble FG Diez N Harte T Kulikova Q Lin V Lombard R Lopez R Mancuso M McHale F Nardone V Silventoinen S Sobhany P Stoehr MA Tuli K Tzouvara R Vaughan D Wu W Zhu R Apweiler 2005 The EMBL nucleotide sequence database Nucleic Acids Res 33 1
11. CEH Lee B Gaëta HR Malming ME Bain WA Sewell AM Collins 2006 Reconsidering the human immunoglobulin heavy chain locus. 1. An evaluation of the expressed human IGHD gene repertoire Immunogenetics 57 917 925
12. CEH Lee KJL Jackson WA Sewell AM Collins 2007 Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia Leuk Res 31 1247 1252
13. P-J Meijer PS Andersen M Haahr Hansen L Steinaa A Jensen J Lantto MB Oleksiewicz K Tengbjerg TR Poulsen VW Coljee S Bregenholt JS Haurum LS Nielsen 2006 Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing J Mol Biol 358 764 772
14. R Mehr M Shannon S Litwin 1999 Models for antigen receptor gene rearrangement. I. Biased receptor editing in B cells: implications for allelic exclusion J Immunol 163 1793 1798
15. T Olee PM Yang KA Siminovitch NJ Olsen J Hillson J Wu F Kozin DA Carson PP Chen 1991 Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases J Clin Invest 88 193 203
16. N Pallares S Lefebvre V Contet F Matsuda MP Lefranc 1999 The human immunoglobulin heavy variable genes Exp Clin Immunogen 16 36 60
17. TF Smith MS Waterman 1981 Identification of common molecular subsequences J Mol Biol 147 195 197
18. K Stamatopoulos C Belessi C Moreno M Boudjograh G Guida T Smilevska L Belhoul S Stella N Stavroyianni M Crespo A Hadzidimitriou L Sutton F Bosch N Laoutaris A Anagnostopoulos E Montserrat A Fassas G Dighiero F Caligaris-Cappio H Merle-Beral P Ghia F Davi 2007 Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations Blood 109 259 270
19. JD Thompson DG Higgins TJ Gibson 1994 CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Nucleic Acids Res 22 4673 4680
20. IM Tomlinson JP Cox E Gherardi AM Lesk C Chothia 1995 The structural repertoire of the human V kappa domain EMBO J 14 4628 4638
21. Y Wang KJL Jackson WA Sewell AM Collins 2008 Many human immunoglobulin heavy-chain IGHV gene polymorphisms have been reported in error Immunol Cell Biol 86 111 115
22. HG Zachau 1993 The immunoglobulin kappa locus-or-what has been learned from looking closely at one-tenth of a percent of the human genome Gene 135 167 173