Linkage and association study of late-onset alzheimer disease families linked to 9p21.3

Annals of Human Genetics

Volumn 72, Issue 6, 2008, Pages 725-731

  Züchner, Stephen ^a   Gilbert, J R ^a   Martin, E R ^a   Leon Guerrero, C R ^b   Xu, P T ^b   Browning, C ^b   Bronson, P G ^b   Whitehead, P ^a   Schmechel, D E ^b   Haines, J L ^c   Pericak Vance, M A ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer disease; Associationstudy; Cyclin dependent kinase inhibitor 2B; Linkage study

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; UNTRANSLATED RNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CHROMOSOME 9P; CONTROLLED STUDY; DOMINANT INHERITANCE; FAMILIAL DISEASE; FEMALE; GENE IDENTIFICATION; GENE LOCATION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; SAMPLING; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CHROMOSOMES, HUMAN, PAIR 9; FAMILY; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 54049142494     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2008.00474.x     Document Type: Article

References (30)

1. Abecasis, G. R. & Cookson, W. O. (2000) GOLD - graphical overview of linkage disequilibrium. BioInformatics 16, 182-183.
2. Arendt, T., Rodel, L., Gartner, U. & Holzer, M. (1996) Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport 7, 3047-3049.
3. Bhat, A., Heath, S. C. & Ott, J. (1999) Hetergeneity for multiple disease loci in linkage analysis. Hum Hered 49, 229-231.
4. Blacker, D., Bertram, L., Saunders, A. J., Moscarillo, T. J., Albert, M. S., Wiener, H., Perry, R. T., Collins, J. S., Harrell, L. E., Go, R. C., Mahoney, A., Beaty, T., Fallin, M. D., Avramopoulos, D., Chase, G. A., Folstein, M. F., McInnis, M. G., Bassett, S. S., Doheny, K. J., Pugh, E. W. & Tanzi, R. E. (2003) Results of a high-resolution genome screen of 437 Alzheimer's Disease families. Hum Mol Genet 12, 23-32.
5. Braak, H. & Braak, E. (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82, 239-259.
6. Carlson, C. S., Eberle, M. A., Rieder, M. J., Yi, Q., Kruglyak, L. & Nickerson, D. A. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 74, 106-120.
7. Cottingham, R. W., Idury, R. M. & Schaffer, A. A. (1993) Faster sequential genetic linkage computations. Am J Hum Genet 53, 252-263.
8. Farrer, L. A. (1997) Genetics and the dementia patient. Neurologist 3, 13-30.
9. Farrer, L. A., Bowirrat, A., Friedland, R. P., Waraska, K., Korczyn, A. D. & Baldwin, C. T. (2003) Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Hum Mol Genet 12, 415-422.
10. Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M. A., Roses, A., Williamson, R., Rossor, M., Owen, M. & Hardy, J. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706.
11. Guttman, R., Altman, R. D. & Nielsen, N. H. (1999) Alzheimer disease: Report of the Council on Scientific Affairs. Archives of Family Medicine 8, 347-353.
12. Haynes, C., Speer, M. C., Peedin, M., Roses, A. D., Haines, J. L., Vance, J. M., & Pericak-Vance, M. A. (1995) PEDIGENE: A comprehensive data management system to facilitate efficient and rapid disease gene mapping. Am J Hum Genet 57, A193.
13. Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A. & Evans, D. A. (2003) Alzheimer disease in the US population -Prevalence estimates using the 2000 census. Arch Neurol 60, 1119-1122.
14. Kehoe, P., Wavrant-De Vrieze, F., Crook, R., Wu, W. S., Holmans, P., Fenton, I., Spurlock, G., Norton, N., Williams, H., Williams, N., Lovestone, S., Perez-Tur, J., Hutton, M., Chartier-Harlin, M. C., Shears, S., Roehl, K., Booth, J., Van Voorst, W., Ramic, D., Williams, J., Goate, A., Hardy, J. & Owen, M. J. (1999) A full genome scan for late onset Alzheimer's disease. Hum Mol Genet 8, 237-245.
15. Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C. E., Jondro, P. D., Schmidt, S. D., Wang, K., Crowley, A. C., Fu, Y. H., Guenette, S. Y., Galas, D., Nemens, E., Wijsman, E. M., Bird, T. D., Schellenberg, G. D. & Tanzi, R. E. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
16. Lewis, PO & Zaykin, D. (2000) Genetic Data Analysis: Computer program for analysis of allelic data.
17. Luth, H. J., Holzer, M., Gertz, H. J. & Arendt, T. (2000) Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a. Brain Res 852, 45-55.
18. Martin, E. R., Bass, M. P., Gilbert, J. R., Pericak-Vance, M. A. & Hauser, E. R. (2003) Genotype-based association test for general pedigrees: The genotype-PDT. Genet Epidemiol 25, 203-213.
19. McKhann, G., Drachman, D. & Folstein, M. (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
20. Myers, A., Wavrant De-Vrieze, F., Holmans, P., Hamshere, M., Crook, R., Compton, D., Marshall, H. et al. (2002) Full genome screen for Alzheimer disease: Stage II analysis. Am J Med Genet 114, 235-244.
21. O'Connell, J. R. & Weeks, D. E. (1998) PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63, 259-266.
22. Pericak-Vance, M. A., Bass, M. P., Yamaoka, L. H., Gaskell, P. C., Scott, W. K., Terwedow, H. A., Menold, M. M., Conneally, P. M., Small, G. W., Vance, J. M., Saunders, A. M., Roses, A. D. & Haines, J. L. (1997) Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 278, 1237-1241.
23. Pericak-Vance, M. A., Grubber, J., Bailey, L. R., Hedges, D., West, S., Kemmerer, B., Hall, J. L., Saunders, A. M., Roses, A. D., Small, G. W., Scott, W. K., Conneally, P. M., Vance, J. M. & Haines, J. L. (2000) Identification of novel genes in late-onset Alzheimer disease. Exp Gerontol 35, 1343-1352.
24. Rimmler, J., McDowell, J. G., Slotterback, B. D., Haynes, C. S., Menold, M. M., Rogala, A., Speer, M. C., Gilbert, J. R., Hauser, E. R., Vance, J. M., & Pericak-Vance, M. A. (1998) Development of a data coordinating center (DCC): Data quality control for complex disease studies. Am J Hum Genet 63, 240.
25. Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K. & Tsuda, T. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
26. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H. et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
27. Ueberham, U. & Arendt, T. (2005) The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 4, 293-306.
28. Ueberham, U., Hessel, A. & Arendt, T. (2003) Cyclin C expression is involved in the pathogenesis of Alzheimer's disease. Neurobiol Aging 24, 427-435.
29. Wisniewski, T., Golabek, A., Matsubara, E., Ghiso, J. & Frangione, B. (1993) Apolipoprotein E: Binding to soluble Alzheimer's beta-amyloid. Biochem Biophys Res Commun 192, 359-365.
30. Xu, H., Gregory, S. G., Hauser, E. R., Stenger, J. E., Pericak-Vance, M. A., Vance, J. M., Zuchner, S. & Hauser, M. A. (2005) SNPselector: A web tool for selecting SNPs for genetic association studies. BioInformatics 21, 4181-4186.