Prophylactic phenobarbital administration after resolution of neonatal seizures: Survey of current practice

Pediatrics

Volumn 122, Issue 4, 2008, Pages 731-735

  Guillet, Ronnie ^a   Kwon, Jennifer M ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Neonatal seizures; Phenobarbital; Survey

Indexed keywords

PHENOBARBITAL; ANTICONVULSIVE AGENT;

ARTICLE; CLINICAL PRACTICE; HEALTH SURVEY; HUMAN; MEDICAL SPECIALIST; NEWBORN DISEASE; PHYSICIAN; PHYSICIAN ATTITUDE; PRIORITY JOURNAL; RECURRENT DISEASE; SEIZURE; TREATMENT DURATION; CLINICAL COMPETENCE; CLINICAL TRIAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG UTILIZATION; HEALTH PERSONNEL ATTITUDE; INCIDENCE; MULTICENTER STUDY; NEWBORN; PROGNOSIS; QUESTIONNAIRE; STATISTICS; UNITED STATES;

ANTICONVULSANTS; ATTITUDE OF HEALTH PERSONNEL; CLINICAL COMPETENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG UTILIZATION; HUMANS; INCIDENCE; INFANT, NEWBORN; PHENOBARBITAL; PROGNOSIS; QUESTIONNAIRES; SEIZURES; UNITED STATES;

EID: 54049140898     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-3278     Document Type: Article

References (21)

1. Rennie JM, Boylan GB. Neonatal seizures and their treatment. Curr Opin Neurol. 2003;16(2):177-181
2. Rennie JM. Neonatal seizures. Eur J Pediatr. 1997;156(2): 83-87
3. Scher MS, Aso K, Beggarly ME, Hamid MY, Steppe DA, Painter MJ. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics. 1993;91(1):128-134
4. Boer HR, Gal P. Neonatal seizures: a survey of current practice. Clin Pediatr (Phila). 1982;21(8):453-457
5. Massingale TW, Buttross S. Survey of treatment practices for neonatal seizures. J Perinatol. 1993;13(2):107-110
6. Fan J, Upadhye S, Worster A. Understanding receiver operating characteristic (ROC) curves. CJEM. 2006;8(1):19-20
7. Diaz J, Schain RJ. Phenobarbital: effects of long-term administration on behavior and brain of artificially reared rats. Science. 1978;199(4324):90-91
8. Holden KR, Mellits ED, Freeman JM. Neonatal seizures, part I: correlation of prenatal and perinatal events with outcomes. Pediatrics. 1982;70(2):165-176
9. Gal P. Anticonvulsant therapy after neonatal seizures: how long should it be continued? Part I: a case for early discontinuation of anticonvulsants. Pharmacotherapy. 1985;5(5): 268-273
10. Clancy RR, Legido A. Postnatal epilepsy after EEG-confirmed neonatal seizures. Epilepsia. 1991;32(1):69-76
11. Guillet R, Kwon J. Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. J Child Neurol. 2007;22(4): 389-395
12. Ellison PH, Largent JA, Bahr JP. A scoring system to predict outcome following neonatal seizures. J Pediatr. 1981;99(3): 455-459
13. Scarpa P, Chierici R, Tamisari L, Fortini C, Volpato S. Criteria for discontinuing neonatal seizure therapy: a long-term appraisal. Brain Dev. 1983;5(6):541-548
14. Farwell JR, Lee YJ, Hirtz DG, Sulzbacher SI, Ellenberg JH, Nelson KB. Phenobarbital for febrile seizures: effects on intelligence and on seizure recurrence. N Engl J Med. 1990;322(6): 364-369
15. Sulzbacher S, Farwell JR, Temkin N, Lu AS, Hirtz DG. Late cognitive effects of early treatment with phenobarbital. Clin Pediatr (Phila). 1999;38(7):387-394
16. Cull WL, O'Connor KG, Sharp S, Tang SF. Response rates and response bias for 50 surveys of pediatricians. Health Serv Res. 2005;40(1):213-226
17. Haut SR, Veliskova J, Moshe SL. Susceptibility of immature and adult brains to seizure effects. Lancet Neurol. 2004;3(10): 608-617
18. McCabe BK, Silveira DC, Cilio MR, et al. Reduced neurogenesis after neonatal seizures. J Neurosci. 2001;21(6):2094-2103
19. Holmes GL, Ben-Ari Y. Seizures in the developing brain: perhaps not so benign after all. Neuron. 1998;21(6):1231-1234
20. Holmes GL, Gairsa JL, Chevassus-Au-Louis N, Ben-Ari Y. Consequences of neonatal seizures in the rat: morphological and behavioral effects. Ann Neurol. 1998;44(6):845-857
21. van der Pol MC, Hadders-Algra M, Huisjes HJ, Touwen BC. Antiepileptic medication in pregnancy: late effects on the children's central nervous system development. Am J Obstet Gynecol. 1991;164(1):121-128