Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site

Journal of Biological Chemistry

Volumn 283, Issue 36, 2008, Pages 24534-24545

  Kahsai, Alem W ^a   Cui, Junru ^a   Kaniskan, H Ümit ^b   Garner, Philip P ^b   Fenteany, Gabriel ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; AGGLOMERATION; BINDING ENERGY; BINDING SITES; BIOMOLECULES; CARBOHYDRATES; CELL ADHESION; CELL MEMBRANES; CELLS; HYDROCARBONS; NUCLEIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RNA; TARGETS;

BINDING PROTEINS; CANINE KIDNEYS; CARBOHYDRATE BINDINGS; CARBOHYDRATE RECOGNITIONS; CELL MIGRATIONS; CELL MOTILITIES; CELLULAR EFFECTS; CYTOSKELETON; DISEASE PROCESSES; DO-MAINS; EXTRACELLULAR MATRIXES; GALECTIN; IN CELLS; IN VITRO; INDEPENDENT FUNCTIONS; LINKER PROTEINS; MULTI-FUNCTIONAL; NATURAL PRODUCTS; OVEREXPRESSING CELLS; OVEREXPRESSION; POTENT INHIBITORS; PROTEIN TARGETS; RNA INTERFERENCES; SECONDARY TARGETS; SEMISYNTHETIC DERIVATIVES; SMALL ORGANIC MOLECULES; SYNTHETIC MOLECULES; TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINES;

CYTOLOGY;

DX 521; GALECTIN 3; HUK 921; RADIXIN; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; DNA; DX 52-1; ISOQUINOLINE DERIVATIVE; MEMBRANE PROTEIN; QUINOCARCIN; QUINOCARMYCIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; ALKYLATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL MOTION; CHEMISTRY; DOG; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

ALKYLATION; ANIMALS; BINDING SITES; CELL ADHESION; CELL LINE; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DNA; DOGS; GALECTIN 3; GENE EXPRESSION; HUMANS; ISOQUINOLINES; MEMBRANE PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 54049134102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800006200     Document Type: Article

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