Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac

European Journal of Medicinal Chemistry

Volumn 43, Issue 11, 2008, Pages 2464-2472

  Mishra, Ashutosh ^a   Veerasamy, Ravichandran ^a   Jain, Prateek Kumar ^a   Dixit, Vinod Kumar ^a   Agrawal, Ram Kishor ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Amino acid conjugates; Ketorolac; Pharmacodyanamics; Pharmacokinetics; Prodrugs

Indexed keywords

5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N (2 DIETHYLSUCCINATE)]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N (2 ETHYLPROPIONATE)] CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N (2' DIETHYLGLUTAMATE)]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N (3 ETHYLPROPIONATE)] CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N (ETHYLACETATE)]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N [2 (3 METHYL)ETHYLBUTYRATE]]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N [2 (3 METHYL)ETHYLPENTOATE]]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N [2 (3 PHENYL)ETHYLPROPIONATE]]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 [N [2 [3 (3 BENZIMIDAZOLE)]ETHYLPROPIONATE]]CARBOXAMIDE; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE [N [2 (4 METHYL)ETHYLPENTOATE]]CARBOXAMIDE; AMIDE; AMINO ACID; KETOROLAC; PRODRUG; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONJUGATE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG SYNTHESIS; MALE; NONHUMAN; PARTITION COEFFICIENT; PLASMA PROTEIN BINDING; RAT; ULCEROGENESIS;

AMIDES; ANIMALS; HUMANS; KETOROLAC; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; PRODRUGS; RATS; RATS, WISTAR; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; ULCER;

EID: 54049129330     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.09.011     Document Type: Article

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