In vitro biological evaluation of folate-functionalized block copolymer micelles for selective anti-cancer drug delivery

Macromolecular Bioscience

Volumn 8, Issue 7, 2008, Pages 615-626

  Licciardi, Mariano ^a   Craparo, Emmanuela F ^a   Giammona, Gaetano ^a   Armes, Steven P ^b   Tang, Yiqing ^c   Lewis, Andrew L ^c  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c BIOCOMPATIBLES UK LTD   (United Kingdom)

Author keywords

Biocompatible; Block copolymers; Cancer targeting; Folate functionalized; pH responsive

Indexed keywords

ABS RESINS; ACIDS; BLOCK COPOLYMERS; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; COLLOIDS; COPOLYMERIZATION; CYTOLOGY; DRUG DELIVERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MICELLES; MICROSCOPIC EXAMINATION; MODEL PREDICTIVE CONTROL; ORGANIC ACIDS; ORGANIC POLYMERS; PLASTIC PRODUCTS; POLYMERS; PREDICTIVE CONTROL SYSTEMS; TUMORS;

ANTI-CANCER DRUGS; BIOCOMPATIBLE; BIOLOGICAL EVALUATIONS; CANCER CELLS; CANCER-TARGETING; CELL VIABILITIES; CHAIN ENDS; COLON CARCINOMA CELLS; COPOLYMER MICELLES; DIBLOCK-COPOLYMER; DRUG UPTAKES; DYNAMIC LIGHT; ETHYL METHACRYLATES; FOLATE RECEPTORS; FOLATE-FUNCTIONALIZED; FOLIC ACIDS; FUNCTIONALIZED; FUNCTIONALIZED DIBLOCK COPOLYMERS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIES; HYDROPHILIC; HYDROPHOBIC POLIES; IN VITRO; LOADING CAPACITIES; PACLITAXEL; PHOSPHORYLCHOLINE; TAMOXIFEN; TRANSMISSION ELECTRONS; TUMOR CELLS;

CELLS;

ANTINEOPLASTIC AGENT; CHOLINE DERIVATIVE; COPOLYMER; FOLATE RECEPTOR; FOLIC ACID; METHACRYLIC ACID DERIVATIVE; PACLITAXEL; POLY[2 (DIISOPROPYLAMINO)ETHYL METHACRYLATE]; POLY[2 (METHACRYLOYLOXY)ETHYL PHOSPHORYLCHOLINE]; TAMOXIFEN; UNCLASSIFIED DRUG; PHOSPHORYLCHOLINE; POLYMETHACRYLIC ACID; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; CANCER CELL; CELL STRAIN CACO 2; CELL STRAIN K 562; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG TARGETING; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; LIGHT SCATTERING; MICELLIZATION; TRANSMISSION ELECTRON MICROSCOPY; CHEMISTRY; METHODOLOGY; MICELLE; SYNTHESIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CACO-2 CELLS; DRUG DELIVERY SYSTEMS; FOLIC ACID; HUMANS; K562 CELLS; MICELLES; PACLITAXEL; PHOSPHORYLCHOLINE; POLYMETHACRYLIC ACIDS; TAMOXIFEN;

EID: 54049117292     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/mabi.200800009     Document Type: Article

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