Cardiac arrhythmia during propofol sedation

EMA - Emergency Medicine Australasia

Volumn 20, Issue 5, 2008, Pages 437-440

  Douglas, Robert J ^a   Cadogan, Mike ^b,c  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

Cardiac arrhythmia; Emergency medicine; Procedural sedation; Torsade de pointes

Indexed keywords

IMIPRAMINE; MAGNESIUM SULFATE; MORPHINE; PROPOFOL; THIORIDAZINE; TRAMADOL;

AGED; ANAMNESIS; ARTICLE; ASSISTED VENTILATION; BEDTIME DOSAGE; BOLUS INJECTION; CARDIAC PATIENT; CASE REPORT; CAST APPLICATION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL EXAMINATION; DEPRESSION; DRUG SAFETY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; EMERGENCY WARD; FEMALE; FIBULA FRACTURE; FRACTURE REDUCTION; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HUMAN; LEG PAIN; OSTEOARTHRITIS; PAIN ASSESSMENT; PRIORITY JOURNAL; REMISSION; SEDATION; TIBIA FRACTURE; TORSADE DES POINTES; X RAY;

AGED; CONSCIOUS SEDATION; EMERGENCY MEDICINE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; PROPOFOL; TORSADES DE POINTES; VENTRICULAR FIBRILLATION;

EID: 54049099948     PISSN: 17426731     EISSN: 17426723     Source Type: Journal    
DOI: 10.1111/j.1742-6723.2008.01126.x     Document Type: Article

References (13)

1. Bell AJ, Treston G, Cardwell R et al. Optimisation of propofol dose shortens procedural sedation time, prevents resedation and removes the requirement for post-procedure physiologic monitoring. Emerg. Med. Australas. 2007 19 : 411 17.
2. Dunn T, Mossop D, Newton A et al. Propofol for procedural sedation in the emergency department. Emerg. Med. J. 2007 24 : 459 61.
3. Green SM. Propofol in emergency medicine. further evidence of safety (Editorial). Emerg. Med. Australas. 2007 19 : 389 93.
4. Rewari V, Kaul H. Sustained ventricular tachycardia in long QT syndrome: is propofol the culprit? Anesthesiology 2003 99 : 764.
5. Sakabe M, Fujiki A, Inoue H. Propofol induced marked prolongation of QT interval in a patient with acute anterior myocardial infarction. Anesthesiology 2002 97 : 265 6.
6. McConachie I, Keaveny JP, Healey TE et al. Effect of anaesthesia on the QT interval. Br. J. Anaesth. 1989 63 : 558 60.
7. Kleinsasser A, Kuenszberg E, Loeckinger A et al. Sevoflurane, but not propofol, significantly prolongs the QT interval. Anesth. Analg. 2000 90 : 25 7.
8. Cacheaux LP, Topf N, Tibbs GR et al. Impairment of hyperpolarisation- activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J. Pharmacol. Exp. Ther. 2005 315 : 517 25 MR, Moore RA, McQuay HJ. Propofol and bradycardia. causation, frequency and severity. Br. J. Anaesth. 1997 78 : 642 51.
9. Cubeddu LX. QT prolongation and fatal arrhythmias. a review of clinical implications and effects of drugs. Am. J. Ther. 2003 10 : 452 7.
10. Masuda T, Tomiyama Y, Kitahata H et al. Propofol inhibits volume -sensitive chloride channels in human coronary artery smooth muscle cells. Anesth. Analg. 2003 97 : 657 62.
11. Vieweg WV, Wood MA. Tricyclic antidepressants, QT interval prolongation, and torsade de pointes. Psychosomatics 2004 45 : 371 7.
12. Shepherd JT, Vanhoutte PM. Spasm of the coronary arteries: causes and consequences (the scientist's viewpoint). Mayo Clin. Proc. 1985 60 : 33 46.
13. Takahashi N, Ito M, Iwao T et al. Vagal modulation of ventricular tachyarrythmias induced by left ansae subclaviae stimulation in rabbits (Abstract). Jpn. Heart J. 1998 39 : 503 11.