Identifying low-quality preclinical studies

Stroke

Volumn 39, Issue 10, 2008, Pages 2697-2698

  Zivin, Justin A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISUFENTON SODIUM;

CLINICAL STUDY; CLINICAL TRIAL; COMORBIDITY; DIABETES MELLITUS; DRUG RESEARCH; EDITORIAL; FUNDING; HUMAN; HYPERTENSION; NATIONAL HEALTH ORGANIZATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; STROKE; TEMPERATURE; TREATMENT FAILURE; ANIMAL; CONFLICT OF INTEREST; DISEASE MODEL; ETHICS; MEDICAL RESEARCH; METHODOLOGY; NOTE; STANDARD;

ANIMALS; BIOMEDICAL RESEARCH; CONFLICT OF INTEREST; DISEASE MODELS, ANIMAL; RESEARCH DESIGN;

EID: 54049099208     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.519488     Document Type: Editorial

References (5)

1. O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1,026 experimental treatments in acute stroke. Ann Neurol. 2006;59:467-477.
2. Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U, Donnan GA. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke. 2008; 39:2824-2829.
3. Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM, Macleod M, Dirnagl U. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke. 2008; 39:929-934.
4. Macleod MR, O'Collins T, Howells DW, Donnan GA. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke. 2004;35:1203-1208.
5. Buchan A, Pulsinelli WA. Hypothermia but not the n-methyl-d-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neurosci. 1990;10:311.