Significantly shorter telomeres in T-cells of patients with ZAP-70 +/CD38+ chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 143, Issue 3, 2008, Pages 383-386

  Röth, Alexander ^a   De Beer, Dirk ^b   Nückel, Holger ^a   Sellmann, Ludger ^a   Dührsen, Ulrich ^a   Dürig, Jan ^a   Baerlocher, Gabriela M ^b,c  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Chronic lymphocytic leukaemia; Immunosenescence; Microenvironment; T cells; Telomere length

Indexed keywords

CD38 ANTIGEN; PROTEIN KINASE ZAP 70;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER PATIENT; CELL DIVISION; CELL EXPANSION; CELL SUBPOPULATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROGNOSIS; T LYMPHOCYTE; TELOMERE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD38; ANTIGENS, NEOPLASM; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RETROSPECTIVE STUDIES; T-LYMPHOCYTES; TELOMERE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 54049096017     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07363.x     Document Type: Article

References (15)

1. Baerlocher, G.M., Vulto, I., de Jong, G. Lansdorp, P.M. (2006) Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nature Protocols, 1, 2365 2376.
2. Buschle, M., Campana, D., Carding, S.R., Richard, C., Hoffbrand, A.V. Brenner, M.K. (1993) Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia. The Journal of Experimental Medicine, 177, 213 218.
3. Damle, R.N., Batliwalla, F.M., Ghiotto, F., Valetto, A., Albesiano, E., Sison, C., Allen, S.L., Kolitz, J., Vinciguerra, V.P., Kudalkar, P., Wasil, T., Rai, K.R., Ferrarini, M., Gregersen, P.K. Chiorazzi, N. (2004) Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations. Blood, 103, 375 382.
4. Foa, R., Catovsky, D., Lauria, F. Galton, D.A. (1980) Reduced T-colony forming capacity by T-lymphocytes from B-chronic lymphocyte leukaemia. British Journal of Haematology, 46, 623 625.
5. Garcia, C., Rosen, A., Kimby, E., Aguilar-Santelises, M., Jondal, M., Bjorkhilm, M., Holm, G. Mellstedt, H. (1989) Higher T-cell imbalance and growth factor receptor expression in B-cell chronic lymphocytic leukemia (B-CLL) as compared to monoclonal B-cell lymphocytosis of undetermined significance (B-MLUS). Leukemia Research, 13, 31 37.
6. Ghia, P. Caligaris-Cappio, F. (2000) The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms. Advances in Cancer Research, 79, 157 173.
7. Ghia, P., Strola, G., Granziero, L., Geuna, M., Guida, G., Sallusto, F., Ruffing, N., Montagna, L., Piccoli, P., Chilosi, M. Caligaris-Cappio, F. (2002) Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. European Journal of Immunology, 32, 1403 1413.
8. Grabowski, P., Hultdin, M., Karlsson, K., Tobin, G., Aleskog, A., Thunberg, U., Laurell, A., Sundstrom, C., Rosenquist, R. Roos, G. (2005) Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status. Blood, 105, 4807 4812.
9. Huang, R.W., Tsuda, H. Takatsuki, K. (1993) Interleukin-2 prevents programmed cell death in chronic lymphocytic leukemia cells. International Journal of Hematology, 58, 83 92.
10. Mellstedt, H. Choudhury, A. (2006) T and B cells in B-chronic lymphocytic leukaemia: Faust, Mephistopheles and the pact with the Devil. Cancer Immunology, Immunotherapy, 55, 210 220.
11. Rossi, E., Matutes, E., Morilla, R., Owusu-Ankomah, K., Heffernan, A.M. Catovsky, D. (1996) Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia. Leukemia, 10, 494 497.
12. Sandoval-Montes, C. Santos-Argumedo, L. (2005) CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines. Journal of Leukocyte Biology, 77, 513 521.
13. Schroers, R., Griesinger, F., Trümper, L., Haase, D., Kulle, B., Klein-Hitpass, L., Sellmann, L., Dührsen, U. Dürig, J. (2005) Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Leukemia, 19, 750 758.
14. Verfaillie, C.M., Pera, M.F. Lansdorp, P.M. (2002) Stem cells: hype and reality. Hematology, 369 391.
15. Yamaguchi, H., Calado, R.T., Ly, H., Kajigaya, S., Baerlocher, G.M., Chanock, S.J., Lansdorp, P.M. Young, N.S. (2005) Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. The New England Journal of Medicine, 352, 1413 1424.