Targeted disruption of Hsp110/105 gene protects against ischemic stress

Stroke

Volumn 39, Issue 10, 2008, Pages 2853-2859

  Nakamura, Junji ^a,d   Fujimoto, Motoaki ^b   Yasuda, Kunihiko ^c   Takeda, Kiyoshi ^b   Akira, Shizuo ^e   Hatayama, Takumi ^f   Takagi, Yasushi ^b   Nozaki, Kazuhiko ^b   Hosokawa, Nobuko ^a,d   Nagata, Kazuhiro ^a,d  

^a KYOTO UNIVERSITY   (Japan)

^b GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cerebral ischemia; Focal; Hsp110 105; Hsp70 Hsc70 chaperone activity; Knockout; Mice

Indexed keywords

FIREFLY LUCIFERASE; HEAT SHOCK PROTEIN 110; HEAT SHOCK PROTEIN 70; HSP105 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; FIBROBLAST; GENE; GENE TARGETING; HSP110/105 GENE; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPERFUSION; WILD TYPE; ANIMAL; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CONVALESCENCE; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; HSP110 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECOVERY OF FUNCTION;

EID: 54049086158     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.506188     Document Type: Article

References (30)

1. Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet. 1988; 22:631-677.
2. Ohtsuka K, Suzuki T. Roles of molecular chaperones in the nervous system. Brain Res Bull. 2000;53:141-146.
3. Sharp FR, Massa SM, Swanson RA. Heat-shock protein protection. Trends Neurosci. 1999;22:97-99.
4. Yasuda K, Nakai A, Hatayama T, Nagata K. Cloning and expression of murine high molecular mass heat shock proteins, HSP105. J Biol Chem. 1995;270:29718-29723.
5. Yasuda K, Ishihara K, Nakashima K, Hatayama T. Genomic cloning and promoter analysis of the mouse 105-κDa heat shock protein (HSP105) gene. Biochem Biophys Res Commun. 1999;256:75-80.
6. Hatayama T, Yasuda K. Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. Biochem Biophys Res Commun. 1998;248:395-401.
7. Wakatsuki T, Hatayama T. Characteristic expression of 105-κDa heat shock protein (HSP105) in various tissues of nonstressed and heat-stressed rats. Biol Pharm Bull. 1998;21:905-910.
8. Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J. Cloning of apg-2 encoding a novel member of heat shock protein 110 family. Gene. 1997;189:19-24.
9. Kaneko Y, Nishiyama H, Nonoguchi K, Higashitsuji H, Kishishita M, Fujita J. A novel hsp110-related gene, apg-1, that is abundantly expressed in the testis responds to a low temperature heat shock rather than the traditional elevated temperatures. J Biol Chem. 1997;272:2640-2645.
10. Kojima R, Randall J, Brenner BM, Gullans SR. Osmotic stress protein 94 (Osp94). A new member of the Hsp110/sse gene subfamily. J Biol Chem. 1996;271:12327-12332.
11. Lee-Yoon D, Easton D, Murawski M, Burd R, Subjeck JR. Identification of a major subfamily of large hsp70-like proteins through the cloning of the mammalian 110-kDa heat shock protein. J Biol Chem. 1995;270: 15725-15733.
12. Yagita Y, Kitagawa K, Taguchi A, Ohtsuki T, Kuwabara K, Mabuchi T, Matsumoto M, Yanagihara T, Hori M. Molecular cloning of a novel member of the HSP110 family of genes, ischemia-responsive protein 94 kDa (irp94), expressed in rat brain after transient forebrain ischemia. J Neurochem. 1999;72:1544-1551.
13. Kim H, Huh PW, Kim C, Kim YJ, Park EM, Park YM. Cerebral activation and distribution of inducible hsp110 and hsp70 mRNAs following focal ischemia in rat. Toxicology. 2001;167:135-144.
14. Lee MY, Choi YS, Choi JS, Min DS, Chun MH, Kim ON, Lee SB, Kim SY. An immunohistochemical study of APG-2 protein in the rat hippocampus after transient forebrain ischemia. Brain Res. 2002;924: 237-241.
15. Xue JH, Fukuyama H, Nonoguchi K, Kaneko Y, Kido T, Fukumoto M, Fujibayashi Y, Itoh K, Fujita J. Induction of Apg-1, a member of the heat shock protein 110 family, following transient forebrain ischemia in the rat brain. Biochem Biophys Res Commun. 1998;247:796-801.
16. Yagita Y, Kitagawa K, Ohtsuki T, Tanaka S, Hori M, Matsumoto M. Induction of the HSP110/105 family in the rat hippocampus in cerebral ischemia and ischemic tolerance. J Cereb Blood Flow Metab. 2001;21: 811-819.
17. Yamagishi N, Ishihara K, Hatayama T. Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity. J Biol Chem. 2004;279:41727-41733.
18. Frydman J. Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem. 2001;70:603-647.
19. Dragovic Z, Broadley SA, Shomura Y, Bracher A, Hartl FU. Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J. 2006;25:2519-2528.
20. Raviol H, Sadlish H, Rodriguez F, Mayer MP, Bukau B. Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J. 2006;25:2510-2518.
21. Shaner L, Sousa R, Morano KA. Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone sse1. Biochemistry. 2006;45:15075-15084.
22. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001;21:7724-7732.
23. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994;265:1883-1885.
24. Michels AA, Nguyen VT, Konings AW, Kampinga HH, Bensaude O. Thermostability of a nuclear-targeted luciferase expressed in mammalian cells - destabilizing influence of the intranuclear microenvironment. Eur J Biochem. 1995;234:382-389.
25. Hatayama T, Takigawa T, Takeuchi S, Shiota K. Characteristic expression of high molecular mass heat shock protein HSP105 during mouse embryo development. Cell Struct Funct. 1997;22:517-525.
26. Kirino T. Ischemic tolerance. J Cereb Blood Flow Metab. 2002;22: 1283-1296.
27. Sharp FR, Lu A, Tang Y, Millhorn DE. Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab. 2000;20: 1011-1032.
28. Hu BR, Janelidze S, Ginsberg MD, Busto R, Perez-Pinzon M, Sick TJ, Siesjo BK, Liu CL. Protein aggregation after focal brain ischemia and reperfusion. J Cereb Blood Flow Metab. 2001;21:865-875.
29. Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science. 2002;296:1991-1995.
30. Arya R, Mallik M, Lakhotia SC. Heat shock genes-integrating cell survival and death. J Biosci. 2007;32:595-610.