Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration

International Journal of Pharmaceutics

Volumn 364, Issue 1, 2008, Pages 14-20

  Rhee, Yun Seok ^a   Chang, Si Young ^a   Park, Chun Woong ^a   Chi, Sang Cheol ^a   Park, Eun Seok ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Experimental design; Gel; Ibuprofen; Pharmacokinetic; Transdermal

Indexed keywords

ALCOHOL; CARBOPOL 940; CETOMACROGOL; IBUPROFEN; MACROGOL DERIVATIVE; POLYETHYLENE GLYCOL 7 GLYCERYL COCOATE; POLYOXYETHYLENE OLEYL ETHER; SENTERLAN; TRIETHANOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; GEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; TECHNIQUE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GELS; IBUPROFEN; MICE; MICE, HAIRLESS; RATS; REPRODUCIBILITY OF RESULTS; SKIN ABSORPTION; VEHICLES;

EID: 53949110056     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.07.029     Document Type: Article

References (32)

1. Agyralides G.G., Dallas P.P., and Rekkas D.M. Development and in vitro evaluation of furosemide transdermal formulations using experimental design techniques. Int. J. Pharm. 281 (2004) 35-43
2. Al-Saidan S.M., Krishnaiah Y.S., Chandrasekhar D.V., Lalla J.K., Rama B., Jayaram B., and Bhaskar P. Formulation of an HPMC gel drug reservoir system with ethanol-water as a solvent system and limonene as a penetration enhancer for enhancing in vitro transdermal delivery of nicorandil. Skin Pharmacol. Physiol. 17 (2004) 310-320
3. Babar A., Solanki U.D., Cutie A.J., and Plakogiannis F. Piroxicam release from dermatological bases: in vitro studies using cellulose membrane and hairless mouse skin. Drug Dev. Ind. Pharm. 16 (1990) 523-540
4. Barry B.W. Dermatological Formulations (1983), Marcel Dekker Inc., NY pp. 49-94
5. Berner G., Engels B., and Vögtle-Junkert U. Percutaneous ibuprofen therapy with Trauma-Dolgit gel: bioequivalence studies. Drug. Exp. Clin. Res. 15 (1989) 559-564
6. Brown M.B., Hanpanitcharoen M., and Martin G.P. An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs. Int. J. Pharm. 225 (2001) 113-121
7. Breuer M.M. The interaction between surfactants and keratinous tissues. J. Soc. Cosmet. 30 (1979) 41-64
8. Busson M.J. Update on ibuprofen: review article. J. Int. Med. Res. 14 (1986) 53-62
9. Cappel M.J., and Kreuter J. Effect of non-ionic surfactants on transdermal drug delivery. I. Polysorbates. Int. J. Pharm. 69 (1991) 143-153
10. Chang S.Y., Park S.B., Jung J.H., Shon S.I., and Yoon H.J. Iburpofen heterocyclic esters as dermal prodrugs: in vitro evaluation. S.T.P. Pharma Sci. 7 (1997) 315-319
11. Chen H., Chang X., Du D., Li J., Xu H., and Yang X. Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int. J. Pharm. 315 (2006) 52-58
12. Cilurzo F., Minghetti P., Casiraghi A., Tosi L., Pagani S., and Montanari L. Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen. Eur. J. Pharm. Biopharm. 60 (2005) 61-66
13. Fang C., Liu Y., Ye X., Rong Z.X., Feng X.M., Jiang C.B., and Chen H.Z. Synergistically enhanced transdermal permeation and topical analgesia of tetracaine gel containing menthol and ethanol in experimental and clinical studies. Eur. J. Pharm. Biopharm. 68 (2008) 735-740
14. Giannakou S.A., Dallas P.P., Rekkas D.M., and Choulis N.H. Development and in vitro evaluation of nitrendipine transdermal formulations using experimental design techniques. Int. J. Pharm. 125 (1995) 7-15
15. Godwin D.A., Wiley C.J., and Felton L.A. Using cyclodextrin complexation to enhance secondary photoprotection of topically applied ibuprofen. Eur. J. Pharm. Biopharm. 62 (2006) 85-93
16. Gupta R.R., and Singh K.K. Polyoxyethylene alkyl ethers. In: Rowe R.C., Sheskey P.J., and Owen S.C. (Eds). Handbook of Pharmaceutical Excipients. 5th ed. (2005), American Pharmacists Association, Washington, DC, USA/The Pharmaceutical Press, Royal Pharmaceutical Society of Great Britain, London, England
17. Hamed E., and Sakr A. Application of multiple response optimization technique to extended release formulations design. J. Control. Rel. 73 (2001) 329-338
18. Iervolino M., Cappello B., Raghavan S.L., and Hadgraft J. Penetration enhancement of ibuprofen from supersaturated solutions through human skin. Int. J. Pharm. 212 (2001) 131-141
19. Kang S.H., Chang S.Y., Do K.C., Chi S.C., and Chung D.S. High-performance liquid chromatography with a column-switching system and capillary electrophoresis for the determination of ibuprofen in plasma. J. Chromatogr. B Biomed. Sci. Appl. 712 (1998) 153-160
20. Krishnaiah Y.S., Satyanarayana V., and Bhaskar P. Influence of limonene on the bioavailability of nicardipine hydrochloride from membrane-moderated transdermal therapeutic systems in human volunteers. Int. J. Pharm. 247 (2002) 91-102
21. Krishnaiah Y.S., Al-Saidan S.M., Chandrasekhar D.V., and Satyanarayana V. Bioavailability of nerodilol-based transdermal therapeutic system of nicorandil in human volunteers. J. Control. Rel. 106 (2005) 111-122
22. Li W., Nadig D., Rasmussen H.T., Patel K., and Shah T. Sample preparation optimization for assay of active pharmaceutical ingredients in a transdermal drug delivery system using experimental designs. J. Pharm. Biomed. Anal. 37 (2005) 493-498
23. Lopez V.C., Raghavan S.L., and Snowden M.J. Colloidal microgels as transdermal delivery systems. React. Funct. Polym. 58 (2004) 175-185
24. Muktadir A., Babar A., Cutie A.J., and Plakogiannis F.M. Medicament release from ointment bases. III. Ibuprofen: in vitro release and in-vivo absorption in rabbits. Drug Dev. Ind. Pharm. 12 (1986) 2521-2540
25. Park E.S., Chang S.Y., Hahn M., and Chi S.C. Enhancing effect of polyoxyethylene alkyl ethers on the skin permeation of ibuprofen. Int. J. Pharm. 209 (2000) 109-119
26. Phillips C.A., and Michniak B.B. Transdermal delivery of drugs with differing lipophilicities using azone analogs as dermal penetration enhancers. J. Pharm. Sci. 84 (1995) 1427-1433
27. Ranman M.S., Babbar A., Patel N.K., and Plakogiannis F.M. Medicament release from ointment bases: V. Naproxen in vitro release and in vivo percutaneous absorption in rabbits. Drug Dev. Ind. Pharm. 16 (1990) 651-672
28. Swart H., Breytenbach J.C., Hadgraft J., and du Plessis J. Synthesis and transdermal penetration of NSAID glycoside esters. Int. J. Pharm. 301 (2005) 71-79
29. Takahashi A., Suzuki S., Kawasaki N., Kubo W., Miyazaki S., Loebenberg R., Bachynsky J., and Attwood D. Percutaneous absorption of non-steroidal anti-inflammatory drugs from in situ gelling xyloglucan formulations in rats. Int. J. Pharm. 246 (2002) 179-186
30. Takayama K., and Nagai T. Novel computer optimization methodology for pharmaceutical formulations investigated by using sustained-release granules of indomethacin. Chem. Pharm. Bull. 37 (1989) 160-167
31. Uchida T., Lee C.K., Sekiya N., and Goto S. Enhancement effect of an ethanol/Panasate 800 binary vehicle on anti-inflammatory drug permeation across excised hairless mouse skin. Biol. Pharm. Bull. 16 (1993) 168-171
32. Walters K.A., Walker M., and Olejnik O. Non-ionic surfactant effects on hairless mouse skin permeability characteristics. J. Pharm. Pharmacol. 40 (1987) 525-529