Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: Inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9432-9442

  Chia, Elizabeth W ^a   Pearce, A Norrie ^b   Berridge, Michael V ^a   Larsen, Lesley ^c   Perry, Nigel B ^c   Sansom, Catherine E ^c   Godfrey, Colette A ^c   Hanton, Lyall R ^d   Walton, Michaela ^a   Webb, Victoria L ^f   Copp, Brent R ^b   Harper, Jacquie L ^a  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e Leon)   (New Zealand)

^f NATIONAL INSTITUTE OF WATER AND ATMOSPHERIC RESEARCH   (New Zealand)

Author keywords

Arthritis; Inflammation; Neutrophils; Superoxide; Thiazine quinoline quinones

Indexed keywords

2H PYRIDO[2,3 G][1,4]BENZOTHIAZINE 5,10 DIOXO 3,4 DIHYDRO N (2 DIMETHYLAMINOETHYL) 1,1 DIOXO 7 CARBOXAMIDE; BICYCLO COMPOUND; QUINOLINE DERIVATIVE; QUINONE DERIVATIVE; SUPEROXIDE; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; GOUT; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RESPIRATORY BURST; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, GOUTY; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HL-60 CELLS; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS; QUINOLINES; QUINONES; RESPIRATORY BURST; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES; THIAZINES;

EID: 53949104202     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.052     Document Type: Article

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