Ionophore antibiotics: Toxicity, mode of action and neurotoxic aspect of carboxylic ionophores

Journal of Animal and Veterinary Advances

Volumn 7, Issue 6, 2008, Pages 748-751

  Kart, Asim ^a   Bilgili, Ali ^b  

^a KAFKAS UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Ionophores; Mechanism; Neurotoxicity; Toxicity

Indexed keywords

EID: 53949096761     PISSN: 16805593     EISSN: 1993601X     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Augustine, P.C., K.L. Watkins and H.D. and Danforth, 1992. Effects of monensin on ultrastructure and cellular invasion by turkey coccidian Eimeria adenoeides and Eimeria meleagrimitis. Poult. Sci., 71: 970-978.
2. Becker, W.M., J.B. Reece and M.F. Poenie, 1996. The World of the Cell. 3rd Edn. The Benjamin/Cummins Publishing Company, Menlopark, California, pp: 207-209.
3. Bergen, W.G. and D.B. Bates, 1984. Ionophores: Their effect on production efficiency and mode of action. J. Anim. Sci., 58: 1465-1483.
4. Elsasser, T.H., 1984. Potential interactions of Ionophore drugs with divalent cations and their function in the Animal Body. J. Anim. Sci., 59: 845-853.
5. Gad, S.C., C. Reilly, K. Siino and F.A. Gavigan, 1985. Thirteen Cationic Ionophores: Their Acute Toxicity, Neurobehavioral and Membrane Effects, Drug Chem. Toxicol., 8: 451-468.
6. Galitzer, S.J. and F.W. Oehme, 1984. A Literature review on the toxicity of Lasalocid, A Polyether antibiotic. Vet. Hum. Toxicol., 26: 322-326.
7. Galitzer, S.J., S.M. Kruckenberg and J.R. Kidd, 1986. Pathological changes associated with experimental lasalocid and monensin toxicosis in cattle. Am. J. Vet. Res., 47: 2624-2626.
8. Gregory, D.G., S.L. Vanhooser and E.L. Stair, 1995. Light and Electron microscopic lesions in peripheral nerves of broiler chickens due to Roxarsone and Lasalocid Toxicoses. Avian Dis., 39: 408-416.
9. Halvorson, D.A., C. Van Dijk and P. Brown, 1982. Ionophore Toxicity in Turkey Breeders. Avian Dis., 26: 634-639.
10. Hanson, L.J., H.G. Eisenbeis and S.V. Givens, 1981. Toxic effect of Lasalocid in Horses. Am. J. Vet. Res., 42 (3): 456-461.
11. Jansson, S.E., E. Heinonen, V. Heinänen, E.M. Gripenberg, E.M. Tolppanen and T. Salmi, 1976. On the Effect of the Ionophore X-537A on Neuromuscular Transmission in the Rat. Life Sci., 18: 1359-1366.
12. Kanje, M. and M. Hanson, 1981. Inhibition of Rapid Axonal Transport in vitro by the Ionophores X-537 and A 23187. Brain Res., 204: 43-50.
13. Mollenhauer., H.H., D.J. Morre and L.D. Rowe, 1990. Alteration of intracellular traffic, specifity and relationship to toxicity, Biochim. Biophys. Acta, 1031: 225-246.
14. Nagaraja, T.G., T.B., Avery, EE. Bartley, SJ. Galitzer and A.D. Dayton, 1981. Prevention of Lactic Acidosis in Cattle by Lasalocid or Monensin. J. Anim. Sci., 53: 206-215.
15. Novilla, M.N., 1992. The Veterinary Importance of the Toxic Syndrome Induced by Ionophores. Vet. Hum. Toxicol., 34: 66-70.
16. Oehme, F.W. and J.A. Pickrel, 1999. An Analysis of the Chronic Oral Toxicity of Polyether Ionophore Antibiotics in Animals. Vet. Hum. Toxicol., 41: 251-257.
17. Ojcius, D.M., A. Zychlinsky, L.M. Zheng and J.D. Young, 1991. Ionophore-induced apoptosis: Role of DNA fragmentation and calcium fluxes. Exp. Cell. Res., 197: 43-49.
18. Osweiler, G.D., 1996. Toxicology, Williams and Wilkins, Philadelphia, PA, pp: 337-340.
19. Perlman, R.L., A.F. Cossi and L.W. Role, 1980. Mechanism of Ionophore Induced Catecholamine Secretion, J. Pharmacol. Exp. Ther., 213: 241-246.
20. Pressman, B.C., 1976. Biological application of Ionophores. Annu. Rev. Biochem., pp: 501-530.
21. Richter, J.A., 1977. The Ionophore X537A (Lasalocid) Transiently increases Acetylcholine release from Rat Brain in vitro. Life Sci., 20: 701-713.
22. Roder, J.D., 1996. Lasalocid induced neuropathy. Ph.D Thesis, Oklahoma State University, Stillwater, Oklahoma, USA.
23. Safran, N., R. Haring and D. Gurwitz, 1996. Selective Neurotoxicity Induced by the Ionophore Lasalocid in Rat Dissociated Cerebral Cultures, Involvement of the NMDA Receptor/Channel. Neurotoxicol., 17: 883-896.
24. Shier, W.T. and D.J. DuBourdieu, 1992. Sodium- and Calcium-Dependent Steps in the Mechanism of Neonatal Rat Cardiac Myocyte Killing by Ionophores. I. The sodium-carrying ionophore, monensin. Toxicol. Appl. Pharmacol., 116: 38-46.
25. Smith, C.K. and R.B. Galloway, 1983. Influence of monensin on cation influx and glycolysis of Eimeria tenella sporozoites in vitro. J. Parasitol., 69: 666-670.
26. Tymianski, M. and C.H. Tatar, 1996. Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurg., 38: 1176-1195.
27. Van der Linde-Sipman, J.S., T.S.G.A.M. Van den Ingh, J.J. Van Nes, H. Verhagen, J.G.T.M. Kersten, A.C. Beynen and R. Plekkringa, 1999. Salinomycin-induced polyneuropathy in Cats: Morphologic and Epidemiologic data. Vet. Pathol., 36: 152-156.
28. Wilson, J.S., 1980. Toxic myopathy in a dog associated with the presence of monensin in dry food. Can. Vet. J., 21: 30-31.