Chromosomal instability (CIN) leads to clone extinction, not cancer

Medical Hypotheses

Volumn 71, Issue 6, 2008, Pages 983-

  Parris, George E ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; CARCINOGENESIS; CELL FUSION; CHROMOSOMAL INSTABILITY; GENE MUTATION; HUMAN; LETTER; MOLECULAR CLOCK; PRIORITY JOURNAL;

ANEUPLOIDY; CHROMOSOMAL INSTABILITY; HUMANS; MOSAICISM; MUTATION; NEOPLASMS;

EID: 53949090790     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.07.046     Document Type: Letter

References (6)

1. Parris G.E. Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species. Med Hypotheses 65 (2005) 846-850
2. Parris G.E. The cell clone ecology hypothesis and the cell fusion model of cancer progression and metastasis: history and experimental support. Med Hypotheses 66 (2006) 76-83
3. Matsuura S., Ito E., Tauchi H., Komatsu K., Ikeuchi T., and Kajii T. Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic-spindle checkpoint. Am J Hum Genet 67 (2000) 483-486
4. Kajii T., Kawai T., Takumi T., et al. Mosaic variegated aneuploidy with multiple congenital abnormalities: homozygosity for total premature chromatid separation trait. Am J Med Genet 7 (1998) 245-249
5. Limwongse C., Schwartz S., Bocian M., and Robin N.H. Child with mosaic variegated aneuploidy and embryonal rhabdomyosarcoma. Am J Med Genet 82 (1999) 20-24
6. Garcia-Castillo H., Vasquez A.I., Rivera H., and Barros-Nunez P. Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: delineation of clinical subtypes. Am J Med Genet A 146A (2008) 1787-1795