Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 21, 2008, Pages 5725-5728

  Jiang, Songchun ^a   Crogan Grundy, Candace ^a   Drewe, John ^a   Tseng, Ben ^a   Cai, Sui Xiong ^a  

^a EpiCept Corporation   (United States)

Author keywords

Anticancer agents; Apoptosis inducers; Tubulin inhibitors

Indexed keywords

(NAPHTHALEN 4 YL)(PHENYL)METHANONE DERIVATIVE; [1 (DIMETHYLAMINO)NAPHTHALEN 4 YL][4 (DIMETHYLAMINO)PHENYL]METHANONE; N METHYL N PHENYLNAPHTHALEN 1 AMINE DERIVATIVE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HCT116; DRUG POTENCY; DRUG STRUCTURE; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

APOPTOSIS; CASPASES; CELL DIVISION; CELL LINE, TUMOR; DRUG DISCOVERY; ENZYME ACTIVATION; HUMANS; NAPHTHALENES;

EID: 53949086502     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.088     Document Type: Article

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