Hypothyroidism and the aorta. Evidence of increased oxidative DNA damage to the aorta of hypothyroid rats

In Vivo

Volumn 22, Issue 5, 2008, Pages 603-608

  Moulakakis, Konstantinos G ^a,c   Poulakou, Maria V ^a   Dosios, Theodosios ^a   Dontas, Ismene ^a   Sokolis, Dimitrios P ^b   Vlachos, Ioannis S ^a   Safioleas, Michael C ^a   Papachristodoulou, Antonios ^a   Karayannacos, Panagiotis E ^b   Perrea, Despina N ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^c NONE   (Greece)

Author keywords

8 oxod G; Aorta; Hypothyroidism; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; C REACTIVE PROTEIN; CELL NUCLEUS DNA; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; PROPYLTHIOURACIL; REACTIVE OXYGEN METABOLITE; THYROID HORMONE; THYROXINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPOTHYROIDISM; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXIDATIVE STRESS; RAT; THYROID HORMONE BLOOD LEVEL; VASCULAR DISEASE; WISTAR RAT;

EID: 53849147604     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Klein I and Ojamaa K: Thyroid hormone and the cardiovascular system. N Engl J Med 344: 501-509, 2001.
2. Ojamaa K, Klemperer JD and Klein I: Acute effects of thyroid hormone on vascular smooth muscle. Thyroid 6: 505-512, 1996.
3. Moulakakis KG, Sokolis DP, Perrea DN, Dosios T, Dontas I, Poulakou MV, Dimitriou CA, Sandris G and Karayannacos PE: The mechanical performance and histomorphological structure of the descending aorta in hyperthyroidism. Angiology 58: 343-352, 2007.
4. Swaroop A and Ramasarma T: Heat exposure and hypothyroid conditions decrease hydrogen peroxide generation in liver mitochondria. Biochemical J 226: 403-408, 1985.
5. Paller MS: Hypothyroidism protects against free radical damage in ischemic acute renal failure. Kidney Intl 29:1162-1166, 1986.
6. Stefanadis C, Dernellis J and Toutouzas P: Mechanical properties of the aorta determined by the pressure-diameter relation. Pathol Biol (Paris) 47: 696-704, 1999.
7. Ohtsuka S, Kakihana M, Watanabe H and Sugishita Y: Chronically decreased aortic distensibility causes deterioration of coronary perfusion during increased left ventricular contraction. J Am Coll Cardiol 24: 1406-1414, 1994.
8. Obuobie K, Smith J, Evans LM, John R, Davies JS and Lazarus JH. Increased central arterial stiffness in hypothyroidism. J Clin Endocrinol Metab 87: 4662-4666, 2002.
9. Wassmann S, Wassmann K and Nickenig G: Modulation of oxidant and antioxidant enzyme expression and function in vascular cells. Hypertension 44: 381-386, 2004.
10. Lounsbury KM, Hu Q and Ziegelstein RC: Calcium signaling and oxidant stress in the vasculature. Free Radic Biol Med 28: 1362-1369, 2000.
11. Cettour-Rose P, Visser TJ, Burger AG and Rohner-Jeanrenaud F: Inhibition of pituitary type 2 deiodinase by reverse triiodothyronine does not alter thyroxine-induced inhibition of thyrotropin secretion in hypothyroid rats. Eur J Endocrinol 153: 429-434, 2005.
12. 2+-ATPase activities in the brain of hyper- and hypothyroid adult rats. Metab Brain Dis 20: 129-139, 2005.
13. Pantos C, Malliopoulou V, Mourouzis I, Sfakianoudis K, Tzeis S, Doumba P, Xinaris C, Cokkinos AD, Carageorgiou H, Varonos DD and Cokkinos DV: Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart to ischaemia-reperfusion. J Endocrinol 178: 427-435, 2003.
14. Buege JA and Aust SD: Microsomal lipid peroxidation. Methods Enzymol 52: 302-310, 1978.
15. Lodish H, Baltimore D, Bork A, Zipurski SL, Matsudaire P and Darnell S: Molecular Cell Biology, 3rd edn. New York, Scientific American Books, 1995.
16. Venditti P, Balestrieri M, Di Meo S and De Leo T: Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues. J Endocrinol 155: 151-157, 1997.
17. Guerrero A, Pamplona R, Portero-Otin M, Barja G and Lopez-Torres M: Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free Radic Biol Med 26: 73-80, 1999.
18. Bilgihan K, Bilgihan A, Diker S, Ataoglu O, Dolapci M, Akata F, Hasanreisoglu B and Turkozkan N: Effects of hyper- and hypo- thyroidism on oxidative stress of the eye in experimental acute anterior uveitis. Acta Ophthalmol Scand 74: 41-43, 1996.
19. Haghdoost S, Czene S, Näslund I, Skog S and Harms-Ringdahl M: Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro. Free Radic Res 39: 153-162, 2005.
20. Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K and Poulsen HE: 8 Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Environ Health 40: 391-404, 1993.
21. Shigenaga MK, Gimeno CJ and Ames BN: Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci USA 86: 9697-9701, 1989.
22. Moulakakis KG, Poulakou MV, Paraskevas KI, Dontas I, Vlachos IS, Sokolis DP, Dosios T, Karayannacos PE and Perrea D: Hyperthyroidism is associated with increased aortic oxidative DNA damage in a rat model. In Vivo 21: 1021-1026, 2007.
23. Aust AE and Eveleigh JF: Mechanisms of DNA oxidation. Proc Soc Exp Biol Med 222: 246-252, 1999.
24. Draper HH, Agarwal S, Nelson DE, Wee JJ, Ghoshal AK and Farber E: Effects of peroxidative stress and age on the concentration of a deoxyguanosine malondialdehyde adduct in rat DNA. Lipids 30: 959-961, 1995.
25. Priemé H, Loft S, Nyyssönen K, Salonen JT and Poulsen HE: No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. Am J Clin Nutr 65: 503-507, 1997.
26. Stevnsner T, Thorslund T, de Souza-Pinto NC and Bohr VA: Mitochondrial repair of 8-oxoguanine and changes with aging. Exp Gerontol 37: 1189-1196, 2002.
27. Loft S and Poulsen HE: Cancer risk and oxidative DNA damage in man. J Mol Med 74: 297-312, 1996.
28. Cooke MS, Evans MD, Dizdaroglu M and Lunec J: Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17: 1195-1214, 2003.
29. Lum H and Roebuck KA: Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 280: C719-C741, 2001.
30. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B and Drexler H: Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 106: 3073-3078, 2002.
31. Wolin MS, Gupte SA and Oeckler RA: Superoxide in the vascular system. J Vasc Res 39: 191-207, 2002.
32. Berry C, Brosnan MJ, Fennell J, Hamilton CA and Dominiczak AF: Oxidative stress and vascular damage in hypertension. Curr Opin Nephrol Hypertens 10: 247-255, 2001.
33. Kobayashi S, Inoue N, Azumi H, Seno T, Hirata K, Kawashima S, Hayashi Y, Itoh H, Yokozaki H and Yokoyama M: Expressional changes of the vascular antioxidant system in atherosclerotic coronary arteries. J Atheroscler Thromb 9: 184-190, 2002.
34. Asayama K, Dobashi K and Hayashibe H, Megata Y and Kato K: Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: a possible mechanism of injury to heart and skeletal muscle in hyperthyroidism. Endocrinology 121: 2112-2118, 1987.
35. Moreno M, Lanni A, Lombardi A and Goglia F: How the thyroid controls metabolism in the rat: different roles for triiodothyronine and diiodothyronines. J Physiol 505: 529-538, 1997.
36. Gredilla R, Lopez Torres M, Portero-Otin M, Pamplona R and Barja G: Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle. Mol Cell Biochem 221: 41-48, 2001.
37. Maytin M, Leopold J and Loscalzo J: Oxidant stress in the vasculature. Curr Atheroscler Rep 1: 156-164, 1999.
38. Kountz WB and Hempelmann LH: Chromatrophic degeneration and rupture of the aorta following thyroidectomy in cases of hypertension. Am Heart J 20: 599-610, 1940.
39. Niarchos AP and Finn R: Letter: Association between hypothyroidism and abdominal aneurysm. Br Med J 4: 110, 1973.
40. Gutierrez PS, Pereira MA, Oliveira RC, Stolf NA and Higuchi Mde L: Thyroid hormone levels in patients with aortic dissection: comparison with controls and correlation with the percentage of the aortic media composed of myxoid deposits. Arq Bras Cardiol 82: 134-138, 2004.