Specific methyl group protonation for the measurement of pharmacophore-specific interligand NOE interactions

Chemistry - A European Journal

Volumn 14, Issue 25, 2008, Pages 7517-7520

  Orts, Julien ^a   Grimm, S Kaspar ^b   Griesinger, Christian ^b   Wendt, K Ulrich ^c   Bartoschek, Stefan ^c   Carlomagno, Teresa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Drug discovery; NMR spectroscopy; Pharmacophore mapping; Selective protonation; Specificity

Indexed keywords

FETAL MONITORING; FLOW INTERACTIONS; HYDROCARBONS; LIGANDS; NUCLEAR MAGNETIC RESONANCE; PHARMACODYNAMICS; PROTONATION;

DRUG DISCOVERY; NMR SPECTROSCOPY; PHARMACOPHORE MAPPING; SELECTIVE PROTONATION; SPECIFICITY;

BINDING ENERGY;

AMINO ACID; LIGAND; PROTEIN; PROTON;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACEUTICS;

AMINO ACIDS; BINDING SITES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEINS; PROTONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 53849142587     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200800880     Document Type: Conference Paper

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